Homo sapiens (human): 4988
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Entry
4988 CDS
T01001
Symbol
OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM
Name
(RefSeq) opioid receptor mu 1
KO
K04215
mu-type opioid receptor
Organism
hsa
Homo sapiens (human)
Pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04915
Estrogen signaling pathway
hsa05032
Morphine addiction
Drug target
Acetorphine:
D12700
Acetyldihydrocodeine:
D07557
Alfentanil (
DG00792
):
D00835
<US>
D07122
Allylprodine:
D12662
Alphacetylmethadol:
D12660
Alphameprodine:
D12666
Alphamethadol:
D12674
Alphaprodine:
D12678
Alvimopan:
D02878
<US>
Anileridine (
DG00794
):
D02941
D02942
Asalhydromorphone (
DG02967
):
D11291
D11292
Axelopran (
DG01857
):
D10690
D10740
Benzethidine:
D12685
Benzhydrocodone (
DG01850
):
D10612
D10692
Betacetylmethadol:
D12661
Betameprodine:
D12667
Betamethadol:
D12675
Betaprodine:
D12679
Bevenopran:
D10349
Brifentanil hydrochloride:
D03156
Buprenorphine (
DG00820
):
D00836
<JP/US>
D07132
<JP/US>
Butorphanol (
DG00821
):
D00837
<US>
D03197
Carfentanil (
DG01339
):
D03405
D07620
Cebranopadol:
D10436
Clonitazene:
D12668
Codeine (
DG01076
):
D00195
D02101
<JP>
D03579
D03580
<US>
D07740
Cyclazocine:
D03618
Dextropropoxyphene (
DG00818
):
D00482
<US>
D05632
D07809
Dezocine:
D00838
Diamorphine (
DG01003
):
D07286
D07810
Diampromide:
D12694
Difenoxin (
DG03054
):
D03809
D11583
Dihydrocodeine (
DG00814
):
D01481
<JP>
D03825
D07831
D07832
Diphenoxylate (
DG00090
):
D03860
D07861
Diprenorphine (
DG01273
):
D07863
D07864
Eluxadoline:
D10403
<US>
Ethoheptazine citrate:
D01435
Ethylmorphine (
DG01074
):
D02205
D07929
Etonitazene:
D12669
Etorphine:
D07937
Etoxeridine:
D12680
Fentanyl (
DG00791
):
D00320
<JP/US>
D01399
<JP/US>
D10811
Furethidine:
D12682
Hydrocodone (
DG01075
):
D03725
<US>
D04461
D08045
D08046
Hydromorphinol:
D12686
Hydromorphone (
DG00811
):
D00839
<JP/US>
D08047
Hydroxypethidine:
D12681
Isomethadone:
D12676
Ketobemidone (
DG00815
):
D08100
D08101
Levacetylmethadol (
DG01000
):
D00840
D04716
Levallorphan tartrate:
D02238
<JP>
Levomethadone (
DG01002
):
D08121
D08122
Levomethorphan:
D12696
Levophenacylmorphan:
D12687
Levorphanol (
DG01341
):
D00841
<US>
D08123
Lofentanil oxalate:
D04764
Loperamide (
DG00092
):
D00729
<JP/US>
D08144
Loperamide oxide (
DG00092
):
D07113
Meptazinol (
DG00825
):
D04924
D08182
Methadone (
DG00999
):
D02102
<JP/US>
D08195
Methadyl acetate:
D04973
Methyldesorphine:
D12691
Methyldihydromorphine:
D12689
Methylnaltrexone bromide:
D06618
<US>
Methylsamidorphan (
DG01830
):
D10371
D10648
Metopon:
D12690
Mirfentanil hydrochloride:
D05048
Morpheridin:
D12697
Morphine (
DG00810
):
D00842
<JP/US>
D02271
<JP>
D08233
D08234
Nalbuphine (
DG00822
):
D00843
<US>
D08246
Naldemedine (
DG01342
):
D10188
D10478
<JP/US>
Nalmefene (
DG00998
):
D02104
<US>
D05111
D10812
<JP>
Nalorphine (
DG01151
):
D08247
D08248
Naloxegol (
DG00078
):
D10375
<US>
D10479
Naloxone (
DG01155
):
D01340
<JP/US>
D08249
D11620
<US>
Naltrexone (
DG00997
):
D02095
<US>
D05113
<US>
Nicomorphine (
DG00812
):
D07285
D08273
Norlevorphanol:
D12692
Ocfentanil hydrochloride:
D05217
Oliceridine:
D11214
<US>
Oxycodegol (
DG03013
):
D11424
D11425
Oxycodone (
DG00813
):
D00847
<US>
D03783
D05312
<US>
D05462
<JP>
Oxymorphone (
DG01343
):
D00844
<US>
D08323
Pentazocine (
DG00819
):
D00498
<JP>
D02111
D02227
<JP>
Pethidine (
DG00816
):
D01383
<JP/US>
D08343
Phenampromide:
D12693
Phenomorphan:
D12688
Pholcodine:
D07385
Piminodine:
D12683
Propiram fumarate:
D05631
Quadazocine mesylate:
D05667
Remifentanil (
DG00795
):
D01177
<JP/US>
D08473
Samidorphan (
DG01538
):
D10162
D10163
Sufentanil (
DG00793
):
D00845
<US>
D05938
Tapentadol (
DG00826
):
D06007
D10199
<JP/US>
Tilidine (
DG00823
):
D06147
D08597
Tonazocine mesylate:
D06189
Tramadol (
DG00824
):
D01355
<JP/US>
D08623
Trefentanil hydrochloride:
D06208
Trimebutine (
DG00031
):
D01500
<JP>
D08639
Trimeperidine:
D06268
Xorphanol mesylate:
D06342
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
4988 (OPRM1)
09150 Organismal Systems
09152 Endocrine system
04915 Estrogen signaling pathway
4988 (OPRM1)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
4988 (OPRM1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
4988 (OPRM1)
G protein-coupled receptors [BR:
hsa04030
]
Rhodopsin family
Peptide
Opioid
4988 (OPRM1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
7tm_1
7TM_GPCR_Srsx
7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID:
4988
NCBI-ProteinID:
NP_000905
OMIM:
600018
HGNC:
8156
Ensembl:
ENSG00000112038
UniProt:
P35372
G8XRH5
Structure
PDB
LinkDB
All DBs
Position
6:154010496..154246867
Genome browser
AA seq
400 aa
AA seq
DB search
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atggacagcagcgctgcccccacgaacgccagcaattgcactgatgccttggcgtactca
agttgctccccagcacccagccccggttcctgggtcaacttgtcccacttagatggcaac
ctgtccgacccatgcggtccgaaccgcaccgacctgggcgggagagacagcctgtgccct
ccgaccggcagtccctccatgatcacggccatcacgatcatggccctctactccatcgtg
tgcgtggtggggctcttcggaaacttcctggtcatgtatgtgattgtcagatacaccaag
atgaagactgccaccaacatctacattttcaaccttgctctggcagatgccttagccacc
agtaccctgcccttccagagtgtgaattacctaatgggaacatggccatttggaaccatc
ctttgcaagatagtgatctccatagattactataacatgttcaccagcatattcaccctc
tgcaccatgagtgttgatcgatacattgcagtctgccaccctgtcaaggccttagatttc
cgtactccccgaaatgccaaaattatcaatgtctgcaactggatcctctcttcagccatt
ggtcttcctgtaatgttcatggctacaacaaaatacaggcaaggttccatagattgtaca
ctaacattctctcatccaacctggtactgggaaaacctgctgaagatctgtgttttcatc
ttcgccttcattatgccagtgctcatcattaccgtgtgctatggactgatgatcttgcgc
ctcaagagtgtccgcatgctctctggctccaaagaaaaggacaggaatcttcgaaggatc
accaggatggtgctggtggtggtggctgtgttcatcgtctgctggactcccattcacatt
tacgtcatcattaaagccttggttacaatcccagaaactacgttccagactgtttcttgg
cacttctgcattgctctaggttacacaaacagctgcctcaacccagtcctttatgcattt
ctggatgaaaacttcaaacgatgcttcagagagttctgtatcccaacctcttccaacatt
gagcaacaaaactccactcgaattcgtcagaacactagagaccacccctccacggccaat
acagtggatagaactaatcatcagctagaaaatctggaagcagaaactgctccgttgccc
taa
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