KEGG   Homo sapiens (human): 5019
Entry
5019              CDS       T01001                                 

Gene name
OXCT1, OXCT, SCOT
Definition
(RefSeq) 3-oxoacid CoA-transferase 1
  KO
K01027  3-oxoacid CoA-transferase [EC:2.8.3.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00072  Synthesis and degradation of ketone bodies
hsa00280  Valine, leucine and isoleucine degradation
hsa00650  Butanoate metabolism
hsa01100  Metabolic pathways
Disease
H01121  Succinyl CoA:3-oxoacid CoA transferase (SCOT) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    5019 (OXCT1)
  09103 Lipid metabolism
   00072 Synthesis and degradation of ketone bodies
    5019 (OXCT1)
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    5019 (OXCT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.3  CoA-transferases
    2.8.3.5  3-oxoacid CoA-transferase
     5019 (OXCT1)
SSDB
Motif
Pfam: CoA_trans AcetylCoA_hyd_C
Other DBs
NCBI-GeneID: 5019
NCBI-ProteinID: NP_000427
OMIM: 601424
HGNC: 8527
Ensembl: ENSG00000083720
Vega: OTTHUMG00000094783
Pharos: P55809(Tbio)
UniProt: P55809 A0A024R040
LinkDB
Structure
PDB: 
3DLX

Position
5p13.1
AA seq 520 aa
MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVL
VGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENA
EFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSV
AIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAET
TVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDD
VRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNITVHLQSENGVLGLGPYPRQHEAD
ADLINAGKETVTILPGASFFSSDESFAMIRGGHVDLTMLGAMQVSKYGDLANWMIPGKMV
KGMGGAMDLVSSAKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKAVFDVDK
KKGLTLIELWEGLTVDDVQKSTGCDFAVSPKLMPMQQIAN
NT seq 1563 nt   +upstreamnt  +downstreamnt
atggcggctctcaaactcctctcctccgggcttcggctctgcgcctctgcccgcggatct
ggggcaacctggtacaagggatgtgtttgttccttttccaccagtgctcatcgccatacc
aagttttatacagatccagtagaagctgtaaaagacatccctgatggtgccacggttttg
gttggtggttttgggctatgtggaattccagagaatcttatagatgctttactgaaaact
ggagtaaaaggactaactgcagtcagcaacaatgcaggggttgacaattttggtttgggg
cttttgcttcggtccaagcagataaaacgcatggtctcttcatatgtgggagaaaatgca
gaatttgaacgacagtacttatctggtgaattagaagtggagctgacaccacagggcaca
cttgcagagaggatccgtgcaggcggggctggagttcctgcattttacaccccaacaggg
tatgggaccctggtacaagaaggaggatcgcccatcaaatacaacaaagatggcagtgtt
gccattgccagtaagccaagagaggtgagggagttcaatggtcagcactttattttggag
gaagcaattacaggggattttgctttggtgaaagcctggaaggcggaccgagcaggaaac
gtgattttcaggaaaagtgcaaggaatttcaacttgccaatgtgcaaagctgcagaaacc
acagtggtagaggttgaagaaattgtggatattggagcatttgctccagaagacatccat
attcctcagatttatgtacatcgccttataaagggagaaaaatatgagaaaagaattgag
cgtttatcaatccggaaagagggagatggggaagccaaatctgctaaacctggagatgac
gtaagggaacgaatcatcaagagggccgctcttgagtttgaggatggcatgtatgctaat
ttgggcataggaatccctctcctggccagcaattttatcagcccaaatataactgttcat
cttcaaagtgaaaatggagttctgggtttgggtccatatccacgacaacatgaagctgat
gcagatctcatcaatgcaggcaaggaaacagttactattcttccaggagcctcttttttc
tccagcgatgaatcatttgcaatgattagaggtggacacgtcgatctgacaatgctagga
gcgatgcaggtttccaaatatggtgacctggctaactggatgatacctgggaagatggtg
aaaggaatgggaggtgctatggatttagtgtccagtgcgaaaaccaaagtggtggtcacc
atggagcattctgcaaagggaaatgcacataaaatcatggagaaatgtacattaccattg
actggaaagcaatgtgtcaaccgcattattactgaaaaggctgtgtttgatgtggacaag
aagaaagggttgactctgattgagctctgggaaggcctgacagtggatgacgtacagaag
agtactgggtgtgattttgcagtttcaccaaaactcatgccaatgcagcagatcgcaaat
tga

KEGG   Homo sapiens (human): 64064
Entry
64064             CDS       T01001                                 

Gene name
OXCT2, FKSG25, SCOTT
Definition
(RefSeq) 3-oxoacid CoA-transferase 2
  KO
K01027  3-oxoacid CoA-transferase [EC:2.8.3.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00072  Synthesis and degradation of ketone bodies
hsa00280  Valine, leucine and isoleucine degradation
hsa00650  Butanoate metabolism
hsa01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    64064 (OXCT2)
  09103 Lipid metabolism
   00072 Synthesis and degradation of ketone bodies
    64064 (OXCT2)
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    64064 (OXCT2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.3  CoA-transferases
    2.8.3.5  3-oxoacid CoA-transferase
     64064 (OXCT2)
SSDB
Motif
Pfam: CoA_trans AcetylCoA_hyd_C
Other DBs
NCBI-GeneID: 64064
NCBI-ProteinID: NP_071403
OMIM: 610289
HGNC: 18606
Ensembl: ENSG00000198754
Vega: OTTHUMG00000009249
Pharos: Q9BYC2(Tbio)
UniProt: Q9BYC2
LinkDB
Position
1p34.2
AA seq 517 aa
MAALRLLASVLGRGVPAGGSGLALSQGCARCFATSPRLRAKFYADPVEMVKDISDGATVM
IGGFGLCGIPENLIAALLRTRVKDLQVVSSNVGVEDFGLGLLLAARQVRRIVCSYVGENT
LCESQYLAGELELELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGAPIRYTPDGHL
ALMSQPREVREFNGDHFLLERAIRADFALVKGWKADRAGNVVFRRSARNFNVPMCKAADV
TAVEVEEIVEVGAFPPEDIHVPNIYVDRVIKGQKYEKRIERLTILKEEDGDAGKEEDART
RIIRRAALEFEDGMYANLGIGIPLLASNFISPSMTVHLHSENGILGLGPFPTEDEVDADL
INAGKQTVTVLPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMIPGKKVKGM
GGAMDLVSSQKTRVVVTMQHCTKDNTPKIMEKCTMPLTGKRCVDRIITEKAVFDVHRKKE
LTLRELWEGLTVDDIKKSTGCAFAVSPNLRPMQQVAP
NT seq 1554 nt   +upstreamnt  +downstreamnt
atggcggcgctgcggctcctggcgtcagtgctcgggcgcggggtccccgccggcggctca
gggctcgcgctgtcccagggctgcgcccgctgctttgccaccagtccccggctccgtgcc
aagttctacgcggacccggtggagatggtgaaggacatctctgacggggcgaccgtcatg
atcgggggcttcgggctctgcgggatccccgagaacctgatcgccgcgctgctcaggacc
cgcgtgaaagacctgcaggtggtcagcagcaacgtgggcgtggaggacttcggcctgggc
ctcctgctggccgccaggcaggtccgtcgcatcgtctgttcctacgtgggcgagaacacc
ctgtgcgagagccagtacctggcaggagagctggagctggagctcacgccccagggcacc
ctggccgagcgcatccgcgcggggggcgccggggtgcccgccttctacacccccacgggc
tacgggaccctggtccaggaagggggcgcccccatccgctacaccccggacggccacctg
gcgctcatgagccagccccgagaggtgagggagttcaacggcgaccacttccttttggag
cgcgccatccgggcagacttcgccctggtgaaagggtggaaggccgaccgggcaggaaac
gtggtcttcaggagaagcgcccgcaatttcaacgtgcccatgtgcaaagctgcagacgtc
acggcggtggaggtggaagagatcgtggaggtgggggctttccccccagaagacatccac
gttcctaacatttatgtagatcgcgtgataaaggggcagaaatacgagaaacgaattgag
cgcttaacgatcctgaaagaggaagatggagacgctggaaaggaagaggacgccaggacg
cgcatcatcagacgcgcagctctggaatttgaggacggcatgtacgccaatctgggcata
ggcatccccctgctggccagcaacttcatcagtcccagcatgactgtccatcttcacagt
gagaacgggatcctgggcctgggcccgtttcccacggaagatgaggtggatgccgacctc
atcaatgcaggcaagcagacggtcacggtgcttcccgggggctgcttcttcgccagcgac
gactccttcgccatgatccgagggggacacatccaactaaccatgcttggagccatgcag
gtttccaaatacggcgacctggcgaactggatgatccctggcaagaaggtgaaaggcatg
ggcggtgccatggacttggtgtccagtcagaagaccagagtggtggtcaccatgcagcac
tgcacaaaggacaacacccccaagatcatggagaaatgcaccatgccgctgaccgggaag
cggtgcgtggaccgcatcatcaccgagaaggccgtgtttgacgtgcacaggaagaaagag
ctgacgctgagggagctctgggagggcctgacggtggacgacatcaaaaagagcacgggg
tgtgcctttgctgtgtccccgaacctcaggcccatgcagcaggtggcaccctga

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