Homo sapiens (human): 5142
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Entry
5142 CDS
T01001
Gene name
PDE4B, DPDE4, PDEIVB
Definition
(RefSeq) phosphodiesterase 4B
KO
K13293
cAMP-specific phosphodiesterase 4 [EC:
3.1.4.53
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04024
cAMP signaling pathway
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa05032
Morphine addiction
Drug target
Aminophylline (
DG01062
):
D00227
D05429
<JP>
D11630
<US>
Apremilast:
D08860
<JP/US>
Arofylline:
D02985
Bemoradan:
D03075
Bucladesine (
DG00230
):
D01238
<JP>
D07546
Caffeine (
DG00974
):
D00528
<JP>
D01453
<JP>
D07603
<US>
Choline theophyllinate:
D02017
Cilomilast:
D01704
Cipamfylline:
D03516
Crisaborole:
D10873
<US>
Difamilast:
D11314
Diprophylline:
D00691
<JP>
Drotaverine (
DG00044
):
D07088
D07879
Enprofylline:
D04006
Ensifentrine:
D11743
Etazolate hydrochloride:
D02655
Filaminast:
D04185
Flavoxate (
DG00477
):
D00718
<JP/US>
D07961
Ibudilast:
D01385
<JP>
Lotamilast:
D11305
Moxaverine (
DG00045
):
D07089
D08238
Oxagrelate:
D05278
Papaverine (
DG00043
):
D02218
<JP>
D07425
D07439
Piclamilast:
D05474
Prinoxodan:
D05612
Propentofylline:
D01630
Proxyphylline:
D01771
<JP>
Roflumilast:
D05744
<US>
Rolipram:
D01783
Theophylline (
DG01061
):
D00371
<JP/US>
D01712
D06103
D06104
Theosalicin:
D09822
Tibenelast sodium:
D06132
Tofimilast:
D09020
Trapidil:
D01220
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5142 (PDE4B)
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
5142 (PDE4B)
09150 Organismal Systems
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
5142 (PDE4B)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
5142 (PDE4B)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
5142 (PDE4B)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PDEase_I
PDE4_UCR
Motif
Other DBs
NCBI-GeneID:
5142
NCBI-ProteinID:
NP_001032418
OMIM:
600127
HGNC:
8781
Ensembl:
ENSG00000184588
Vega:
OTTHUMG00000009088
Pharos:
Q07343
(Tclin)
UniProt:
Q07343
X5DNX5
LinkDB
All DBs
Structure
PDB:
4KP6
5OHJ
3FRG
3GWT
3D3P
1F0J
5K6J
4MYQ
1XM6
3O0J
2QYL
3O57
1ROR
1RO6
1XLZ
1RO9
4NW7
1TB5
1XLX
3HMV
1XOS
3W5E
1XMU
1XN0
1XM4
1XOT
5LAQ
1Y2H
1XMY
3O56
3KKT
3WD9
1Y2J
4WZI
3LY2
3G45
4X0F
Thumbnails
Position
1p31.3
AA seq
736 aa
AA seq
DB search
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
NT seq
2211 nt
NT seq
+upstream
nt +downstream
nt
atgaagaaaagcaggagtgtgatgacggtgatggctgatgataatgttaaagattatttt
gaatgtagcttgagtaaatcctacagttcttccagtaacacacttgggatcgacctctgg
agagggagaaggtgttgctcaggaaacttacagttaccaccactgtctcaaagacagagt
gaaagggcaaggactcctgagggagatggtatttccaggccgaccacactgcctttgaca
acgcttccaagcattgctattacaactgtaagccaggagtgctttgatgtggaaaatggc
ccttccccaggtcggagtccactggatccccaggccagctcttccgctgggctggtactt
cacgccacctttcctgggcacagccagcgcagagagtcatttctctacagatcagacagc
gactatgacttgtcaccaaaggcgatgtcgagaaactcttctcttccaagcgagcaacac
ggcgatgacttgattgtaactccttttgcccaggtccttgccagcttgcgaagtgtgaga
aacaacttcactatactgacaaaccttcatggtacatctaacaagaggtccccagctgct
agtcagcctcctgtctccagagtcaacccacaagaagaatcttatcaaaaattagcaatg
gaaacgctggaggaattagactggtgtttagaccagctagagaccatacagacctaccgg
tctgtcagtgagatggcttctaacaagttcaaaagaatgctgaaccgggagctgacacac
ctctcagagatgagccgatcagggaaccaggtgtctgaatacatttcaaatactttctta
gacaagcagaatgatgtggagatcccatctcctacccagaaagacagggagaaaaagaaa
aagcagcagctcatgacccagataagtggagtgaagaaattaatgcatagttcaagccta
aacaatacaagcatctcacgctttggagtcaacactgaaaatgaagatcacctggccaag
gagctggaagacctgaacaaatggggtcttaacatctttaatgtggctggatattctcac
aatagacccctaacatgcatcatgtatgctatattccaggaaagagacctcctaaagaca
ttcagaatctcatctgacacatttataacctacatgatgactttagaagaccattaccat
tctgacgtggcatatcacaacagcctgcacgctgctgatgtagcccagtcgacccatgtt
ctcctttctacaccagcattagacgctgtcttcacagatttggagatcctggctgccatt
tttgcagctgccatccatgacgttgatcatcctggagtctccaatcagtttctcatcaac
acaaattcagaacttgctttgatgtataatgatgaatctgtgttggaaaatcatcacctt
gctgtgggtttcaaactgctgcaagaagaacactgtgacatcttcatgaatctcaccaag
aagcagcgtcagacactcaggaagatggttattgacatggtgttagcaactgatatgtct
aaacatatgagcctgctggcagacctgaagacaatggtagaaacgaagaaagttacaagt
tcaggcgttcttctcctagacaactataccgatcgcattcaggtccttcgcaacatggta
cactgtgcagacctgagcaaccccaccaagtccttggaattgtatcggcaatggacagac
cgcatcatggaggaatttttccagcagggagacaaagagcgggagaggggaatggaaatt
agcccaatgtgtgataaacacacagcttctgtggaaaaatcccaggttggtttcatcgac
tacattgtccatccattgtgggagacatgggcagatttggtacagcctgatgctcaggac
attctcgataccttagaagataacaggaactggtatcagagcatgatacctcaaagtccc
tcaccaccactggacgagcagaacagggactgccagggtctgatggagaagtttcagttt
gaactgactctcgatgaggaagattctgaaggacctgagaaggagggagagggacacagc
tatttcagcagcacaaagacgctttgtgtgattgatccagaaaacagagattccctggga
gagactgacatagacattgcaacagaagacaagtcccccgtggatacataa
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integrated database retrieval system
