Homo sapiens (human): 51426
Entry
51426 CDS
T01001
Gene name
POLK, DINB1, DINP, POLQ
Definition
(RefSeq) DNA polymerase kappa
KO
K03511
DNA polymerase kappa [EC:
2.7.7.7
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03460
Fanconi anemia pathway
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05210
Colorectal cancer
hsa05212
Pancreatic cancer
hsa05213
Endometrial cancer
hsa05214
Glioma
hsa05216
Thyroid cancer
hsa05217
Basal cell carcinoma
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
Network
nt06165
Epstein-Barr virus (EBV)
nt06240
Transcription
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06265
Bladder cancer
nt06266
Non-small cell lung cancer
nt06267
Small cell lung cancer
nt06268
Melanoma
nt06269
Basal cell carcinoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06273
Glioma
nt06274
Thyroid cancer
nt06276
Chronic myeloid leukemia
Element
N00115
Mutation-inactivated TP53 to transcription
N00223
EBV EBNA1 to p53-mediated transcription
N00263
EBV EBNA3C to p53-mediated transcription
N00481
EBV BZLF1 to p53-mediated transcription
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03460 Fanconi anemia pathway
51426 (POLK)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
51426 (POLK)
05202 Transcriptional misregulation in cancer
51426 (POLK)
09162 Cancer: specific types
05210 Colorectal cancer
51426 (POLK)
05212 Pancreatic cancer
51426 (POLK)
05225 Hepatocellular carcinoma
51426 (POLK)
05226 Gastric cancer
51426 (POLK)
05214 Glioma
51426 (POLK)
05216 Thyroid cancer
51426 (POLK)
05220 Chronic myeloid leukemia
51426 (POLK)
05217 Basal cell carcinoma
51426 (POLK)
05218 Melanoma
51426 (POLK)
05213 Endometrial cancer
51426 (POLK)
05224 Breast cancer
51426 (POLK)
05222 Small cell lung cancer
51426 (POLK)
05223 Non-small cell lung cancer
51426 (POLK)
09172 Infectious disease: viral
05169 Epstein-Barr virus infection
51426 (POLK)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins [BR:
hsa03400
]
51426 (POLK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.7 DNA-directed DNA polymerase
51426 (POLK)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic Type
TLS (translesion DNA synthesis) factors
Y-family DNA polymerases
51426 (POLK)
SSDB
Motif
Pfam:
IMS
IMS_C
IMS_HHH
ATP-cone
zf-C2H2_12
Other DBs
NCBI-GeneID:
51426
NCBI-ProteinID:
NP_057302
OMIM:
605650
HGNC:
9183
Ensembl:
ENSG00000122008
Vega:
OTTHUMG00000102107
Pharos:
Q9UBT6
(Tbio)
UniProt:
Q9UBT6
A0A024RAP4
LinkDB
Structure
PDB:
6CST
1T94
5W2C
4U6P
6BRX
4U7C
5W2A
5T14
2OH2
6BS1
2W7O
3IN5
3PZP
2W7P
Position
5q13.3
AA seq
870 aa
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQV
NQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDN
PELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE
VKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNK
LSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFR
IEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKV
TEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER
TFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVST
AEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQAL
SATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQ
VLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFS
CSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALS
NKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCP
VCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTR
TKRPGLMTKYSTSKKIKPNNPKHTLDIFFK
NT seq
2613 nt
+upstream
nt +downstream
nt
atggatagcacaaaggagaagtgtgacagttacaaagatgatcttctgcttaggatggga
cttaatgataataaagcaggaatggaaggattagataaagagaaaattaacaaaattata
atggaagccacgaaggggtccagattttatggaaatgagctcaagaaagaaaagcaagtc
aaccaacgaattgaaaatatgatgcaacaaaaagctcaaatcaccagccaacagctaaga
aaagcacaattacaggttgacagatttgcaatggaattagaacaaagccgaaatttgagc
aataccatagtgcacattgacatggatgctttctatgcagctgtagaaatgagggacaat
ccagaattgaaggataaacccattgctgtaggatcaatgagtatgctgtctacttcaaat
taccatgcaaggagatttggtgttcgtgcagccatgccaggatttattgctaagaggctg
tgcccacaacttataatagtgccccccaactttgacaaataccgagctgtgagtaaagag
gttaaggaaatacttgctgattatgatcccaattttatggccatgagtcttgatgaagcc
tacttgaatataacaaagcacttagaagaaagacaaaattggcctgaggataaaagaagg
tatttcatcaaaatgggaagctctgtagaaaatgataatccaggaaaggaagttaataaa
ctgagtgagcatgaacgatccatctctccactactttttgaagagagtccttctgatgtg
cagcccccaggagatcctttccaagtgaactttgaagaacaaaacaatcctcaaatactc
caaaactcagttgtttttggaacatcagcccaggaagtggtaaaggaaattcgtttcaga
attgagcagaaaacaacactgacagccagtgcaggcattgccccaaatacaatgttagca
aaagtatgcagtgataagaataaaccaaatggacaataccaaattcttcccaatagacaa
gctgtgatggacttcatcaaggatttacccattagaaaggtttctggaataggaaaagtt
acagagaaaatgttaaaggcccttggaattattacatgtacagaactttaccaacagagg
gcattgctttctctccttttctctgaaacatcttggcattatttccttcatatctccttg
ggtctaggttcaacacacctgacgagggatggagagaggaaaagtatgagcgttgagagg
acattcagtgagataaataaagcggaagagcaatacagcctatgtcaagaactttgcagt
gagcttgctcaggatctacagaaagaaagacttaagggtagaactgttaccattaagttg
aagaatgtgaattttgaagtaaaaactcgtgcatctacagtttcatctgttgtttctact
gcagaagaaatatttgccattgctaaggaattgctaaaaacagaaattgatgctgatttt
ccacatcccttgagattaaggcttatgggtgttcggatatctagttttcccaatgaagag
gacaggaaacaccaacaaaggagcattattggctttttacaggctggaaaccaagccctg
tcagccactgagtgtacattagagaaaactgacaaagataagtttgtaaaacctctagaa
atgtctcataagaagagtttctttgataaaaaacgatcagaaaggaaatggagtcaccaa
gatacatttaaatgtgaagccgtgaataaacaaagtttccagacatcacaaccattccaa
gttttaaagaagaagatgaatgagaatttggaaatatcagagaattcagatgactgtcag
atacttacctgtcctgtttgctttagggctcaagggtgcatcagtctggaagccttgaat
aaacatgtagatgaatgtcttgatggaccttcaatcagtgaaaactttaaaatgttctcg
tgttcacatgtttctgctaccaaagttaacaagaaagaaaatgttcctgcttcttcactt
tgtgagaagcaagattatgaagcccatccaaaaattaaagaaatatcttcagtagattgt
atagctttagtagatactatagataactcatctaaagcagaaagcatagatgctttaagt
aataagcatagcaaggaagaatgttctagtctcccaagcaagtcttttaatattgaacac
tgtcatcagaattcttcttctactgtttcattggaaaacgaagatgttggatcatttaga
caagaataccgccagccttacttatgtgaagtgaaaacaggccaagctctagtttgtcct
gtttgtaacgtagaacaaaagacttcagatctaaccctgttcaatgtgcatgtggatgtt
tgcttaaataaaagttttatccaagaattaagaaaggataaatttaacccagttaatcaa
cccaaagaaagctccagaagtactggtagctcaagtggagtacagaaggctgtaacaaga
acaaaaaggccaggattgatgacaaagtactcaacatcaaagaaaataaaaccaaacaat
cccaaacatacccttgatatattttttaagtaa
DBGET
integrated database retrieval system
