KEGG   Homo sapiens (human): 5173
Entry
5173              CDS       T01001                                 

Gene name
PDYN, ADCA, PENKB, SCA23
Definition
(RefSeq) prodynorphin
  KO
K15840  proenkephalin B (prodynorphin)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
Network
nt06410  Calcium signaling
nt06462  Spinocerebellar ataxia
  Element
N00971  Mutation-caused aberrant PDYN to transport of calcium
Disease
H00063  Spinocerebellar ataxia (SCA)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5173 (PDYN)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    5173 (PDYN)
   05022 Pathways of neurodegeneration - multiple diseases
    5173 (PDYN)
  09165 Substance dependence
   05030 Cocaine addiction
    5173 (PDYN)
   05031 Amphetamine addiction
    5173 (PDYN)
   05034 Alcoholism
    5173 (PDYN)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    5173 (PDYN)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   5173 (PDYN)
SSDB
Motif
Pfam: Opiods_neuropep
Other DBs
NCBI-GeneID: 5173
NCBI-ProteinID: NP_001177821
OMIM: 131340
HGNC: 8820
Ensembl: ENSG00000101327
Vega: OTTHUMG00000031683
Pharos: P01213(Tbio)
CPD: C16039 C16040 C16041 C16037 C01574 C16135
UniProt: P01213
LinkDB
Position
20p13
AA seq 254 aa
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWE
RCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKEN
TLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLR
KYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRS
QEDPNAYSGELFDA
NT seq 765 nt   +upstreamnt  +downstreamnt
atggcctggcaggggctggtcctggctgcctgcctcctcatgttcccctccaccacagcg
gactgcctgtcgcggtgctccttgtgtgctgtaaagacccaggatggtcccaaacctatc
aatcccctgatttgctccctgcaatgccaggctgccctgctgccctctgaggaatgggag
agatgccagagctttctgtcttttttcaccccctccacccttgggctcaatgacaaggag
gacttggggagcaagtcggttggggaagggccctacagtgagctggccaagctctctggg
tcattcctgaaggagctggagaaaagcaagtttctcccaagtatctcaacaaaggagaac
actctgagcaagagcctggaggagaagctcaggggtctctctgacgggtttagggaggga
gcagagtctgagctgatgagggatgcccagctgaacgatggtgccatggagactggcaca
ctctatctcgctgaggaggaccccaaggagcaggtcaaacgctatgggggctttttgcgc
aaataccccaagaggagctcagaggtggctggggagggggacggggatagcatgggccat
gaggacctgtacaaacgctatgggggcttcttgcggcgcattcgtcccaagctcaagtgg
gacaaccagaagcgctatggcggttttctccggcgccagttcaaggtggtgactcggtct
caggaagatccgaatgcttactctggagagctttttgatgcataa

KEGG   Homo sapiens (human): 5179
Entry
5179              CDS       T01001                                 

Gene name
PENK, PE, PENK-A
Definition
(RefSeq) proenkephalin
  KO
K18832  proenkephalin A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5179 (PENK)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    5179 (PENK)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   5179 (PENK)
SSDB
Motif
Pfam: Opiods_neuropep SRF-TF
Other DBs
NCBI-GeneID: 5179
NCBI-ProteinID: NP_001129162
OMIM: 131330
HGNC: 8831
Ensembl: ENSG00000181195
Vega: OTTHUMG00000164409
Pharos: P01210(Tbio)
CPD: C11684 C16041 C16042 C16043
UniProt: P01210 A0A024R7V4
LinkDB
Position
8q12.1
AA seq 267 aa
MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLK
IWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPM
EPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEE
EVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEA
LPSDEEGESYSKEVPEMEKRYGGFMRF
NT seq 804 nt   +upstreamnt  +downstreamnt
atggcgcggttcctgacactttgcacttggctgctgttgctcggccccgggctcctggcg
accgtgcgggccgaatgcagccaggattgcgcgacgtgcagctaccgcctagtgcgcccg
gccgacatcaacttcctggcttgcgtaatggaatgtgaaggtaaactgccttctctgaaa
atttgggaaacctgcaaggagctcctgcagctgtccaaaccagagcttcctcaagatggc
accagcaccctcagagaaaatagcaaaccggaagaaagccatttgctagccaaaaggtat
gggggcttcatgaaaaggtatggaggcttcatgaagaaaatggatgagctttatcccatg
gagccagaagaagaggccaatggaagtgagatcctcgccaagcggtatgggggcttcatg
aagaaggatgcagaggaggacgactcgctggccaattcctcagacctgctaaaagagctt
ctggaaacaggggacaaccgagagcgtagccaccaccaggatggcagtgataatgaggaa
gaagtgagcaagagatatgggggcttcatgagaggcttaaagagaagcccccaactggaa
gatgaagccaaagagctgcagaagcgatatgggggcttcatgagaagagtaggtcgccca
gagtggtggatggactaccagaaacggtatggaggtttcctgaagcgctttgccgaggct
ctgccctccgacgaagaaggcgaaagttactccaaagaagttcctgaaatggaaaaaaga
tacggaggatttatgagattttaa

KEGG   Homo sapiens (human): 5443
Entry
5443              CDS       T01001                                 

Gene name
POMC, ACTH, CLIP, LPH, MSH, NPP, OBAIRH, POC
Definition
(RefSeq) proopiomelanocortin
  KO
K05228  proopiomelanocortin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04920  Adipocytokine signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
Network
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00299  Mutation-inactivated MC2R to ACTH-cortisol signaling pathway
N00300  Mutation-inactivated MRAP to ACTH-cortisol signaling pathway
N00318  EGFR-ERK-ACTH signaling pathway
N00319  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
Disease
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    5443 (POMC)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5443 (POMC)
 09150 Organismal Systems
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    5443 (POMC)
   04915 Estrogen signaling pathway
    5443 (POMC)
   04916 Melanogenesis
    5443 (POMC)
   04925 Aldosterone synthesis and secretion
    5443 (POMC)
   04927 Cortisol synthesis and secretion
    5443 (POMC)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    5443 (POMC)
SSDB
Motif
Pfam: ACTH_domain NPP Op_neuropeptide ACTH_assoc
Other DBs
NCBI-GeneID: 5443
NCBI-ProteinID: NP_000930
OMIM: 176830
HGNC: 9201
Ensembl: ENSG00000115138
Vega: OTTHUMG00000094764
Pharos: P01189(Tbio)
CPD: C16019 C16020 C02758 C02017 C02210 C16134 C16136 C16137
UniProt: P01189
LinkDB
Position
2p23.3
AA seq 267 aa
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE
NT seq 804 nt   +upstreamnt  +downstreamnt
atgccgagatcgtgctgcagccgctcgggggccctgttgctggccttgctgcttcaggcc
tccatggaagtgcgtggctggtgcctggagagcagccagtgtcaggacctcaccacggaa
agcaacctgctggagtgcatccgggcctgcaagcccgacctctcggccgagactcccatg
ttcccgggaaatggcgacgagcagcctctgaccgagaacccccggaagtacgtcatgggc
cacttccgctgggaccgattcggccgccgcaacagcagcagcagcggcagcagcggcgca
gggcagaagcgcgaggacgtctcagcgggcgaagactgcggcccgctgcctgagggcggc
cccgagccccgcagcgatggtgccaagccgggcccgcgcgagggcaagcgctcctactcc
atggagcacttccgctggggcaagccggtgggcaagaagcggcgcccagtgaaggtgtac
cctaacggcgccgaggacgagtcggccgaggccttccccctggagttcaagagggagctg
actggccagcgactccgggagggagatggccccgacggccctgccgatgacggcgcaggg
gcccaggccgacctggagcacagcctgctggtggcggccgagaagaaggacgagggcccc
tacaggatggagcacttccgctggggcagcccgcccaaggacaagcgctacggcggtttc
atgacctccgagaagagccagacgcccctggtgacgctgttcaaaaacgccatcatcaag
aacgcctacaagaagggcgagtga

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