Homo sapiens (human): 5295
Entry
5295 CDS
T01001
Gene name
PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA
Definition
(RefSeq) phosphoinositide-3-kinase regulatory subunit 1
KO
K02649
phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa01524
Platinum drug resistance
hsa04012
ErbB signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04070
Phosphatidylinositol signaling system
hsa04071
Sphingolipid signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04140
Autophagy - animal
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04152
AMPK signaling pathway
hsa04210
Apoptosis
hsa04211
Longevity regulating pathway
hsa04213
Longevity regulating pathway - multiple species
hsa04218
Cellular senescence
hsa04360
Axon guidance
hsa04370
VEGF signaling pathway
hsa04380
Osteoclast differentiation
hsa04510
Focal adhesion
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04611
Platelet activation
hsa04620
Toll-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
Jak-STAT signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa04668
TNF signaling pathway
hsa04670
Leukocyte transendothelial migration
hsa04722
Neurotrophin signaling pathway
hsa04725
Cholinergic synapse
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04810
Regulation of actin cytoskeleton
hsa04910
Insulin signaling pathway
hsa04914
Progesterone-mediated oocyte maturation
hsa04915
Estrogen signaling pathway
hsa04917
Prolactin signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa04923
Regulation of lipolysis in adipocytes
hsa04926
Relaxin signaling pathway
hsa04929
GnRH secretion
hsa04930
Type II diabetes mellitus
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease (NAFLD)
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04935
Growth hormone synthesis, secretion and action
hsa04960
Aldosterone-regulated sodium reabsorption
hsa04973
Carbohydrate digestion and absorption
hsa05100
Bacterial invasion of epithelial cells
hsa05131
Shigellosis
hsa05135
Yersinia infection
hsa05142
Chagas disease (American trypanosomiasis)
hsa05146
Amoebiasis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05213
Endometrial cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05230
Central carbon metabolism in cancer
hsa05231
Choline metabolism in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05418
Fluid shear stress and atherosclerosis
Disease
H01370
SHORT syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
5295 (PIK3R1)
04015 Rap1 signaling pathway
5295 (PIK3R1)
04012 ErbB signaling pathway
5295 (PIK3R1)
04370 VEGF signaling pathway
5295 (PIK3R1)
04630 Jak-STAT signaling pathway
5295 (PIK3R1)
04668 TNF signaling pathway
5295 (PIK3R1)
04066 HIF-1 signaling pathway
5295 (PIK3R1)
04068 FoxO signaling pathway
5295 (PIK3R1)
04070 Phosphatidylinositol signaling system
5295 (PIK3R1)
04072 Phospholipase D signaling pathway
5295 (PIK3R1)
04071 Sphingolipid signaling pathway
5295 (PIK3R1)
04024 cAMP signaling pathway
5295 (PIK3R1)
04151 PI3K-Akt signaling pathway
5295 (PIK3R1)
04152 AMPK signaling pathway
5295 (PIK3R1)
04150 mTOR signaling pathway
5295 (PIK3R1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
5295 (PIK3R1)
09143 Cell growth and death
04210 Apoptosis
5295 (PIK3R1)
04218 Cellular senescence
5295 (PIK3R1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
5295 (PIK3R1)
04550 Signaling pathways regulating pluripotency of stem cells
5295 (PIK3R1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
5295 (PIK3R1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
5295 (PIK3R1)
04620 Toll-like receptor signaling pathway
5295 (PIK3R1)
04625 C-type lectin receptor signaling pathway
5295 (PIK3R1)
04650 Natural killer cell mediated cytotoxicity
5295 (PIK3R1)
04660 T cell receptor signaling pathway
5295 (PIK3R1)
04662 B cell receptor signaling pathway
5295 (PIK3R1)
04664 Fc epsilon RI signaling pathway
5295 (PIK3R1)
04666 Fc gamma R-mediated phagocytosis
5295 (PIK3R1)
04670 Leukocyte transendothelial migration
5295 (PIK3R1)
04062 Chemokine signaling pathway
5295 (PIK3R1)
09152 Endocrine system
04910 Insulin signaling pathway
5295 (PIK3R1)
04923 Regulation of lipolysis in adipocytes
5295 (PIK3R1)
04929 GnRH secretion
5295 (PIK3R1)
04915 Estrogen signaling pathway
5295 (PIK3R1)
04914 Progesterone-mediated oocyte maturation
5295 (PIK3R1)
04917 Prolactin signaling pathway
5295 (PIK3R1)
04926 Relaxin signaling pathway
5295 (PIK3R1)
04935 Growth hormone synthesis, secretion and action
5295 (PIK3R1)
04919 Thyroid hormone signaling pathway
5295 (PIK3R1)
09154 Digestive system
04973 Carbohydrate digestion and absorption
5295 (PIK3R1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
5295 (PIK3R1)
09156 Nervous system
04725 Cholinergic synapse
5295 (PIK3R1)
04722 Neurotrophin signaling pathway
5295 (PIK3R1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
5295 (PIK3R1)
09158 Development and regeneration
04360 Axon guidance
5295 (PIK3R1)
04380 Osteoclast differentiation
5295 (PIK3R1)
09149 Aging
04211 Longevity regulating pathway
5295 (PIK3R1)
04213 Longevity regulating pathway - multiple species
5295 (PIK3R1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5295 (PIK3R1)
05206 MicroRNAs in cancer
5295 (PIK3R1)
05205 Proteoglycans in cancer
5295 (PIK3R1)
05203 Viral carcinogenesis
5295 (PIK3R1)
05230 Central carbon metabolism in cancer
5295 (PIK3R1)
05231 Choline metabolism in cancer
5295 (PIK3R1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5295 (PIK3R1)
09162 Cancer: specific types
05210 Colorectal cancer
5295 (PIK3R1)
05212 Pancreatic cancer
5295 (PIK3R1)
05225 Hepatocellular carcinoma
5295 (PIK3R1)
05226 Gastric cancer
5295 (PIK3R1)
05214 Glioma
5295 (PIK3R1)
05221 Acute myeloid leukemia
5295 (PIK3R1)
05220 Chronic myeloid leukemia
5295 (PIK3R1)
05218 Melanoma
5295 (PIK3R1)
05211 Renal cell carcinoma
5295 (PIK3R1)
05215 Prostate cancer
5295 (PIK3R1)
05213 Endometrial cancer
5295 (PIK3R1)
05224 Breast cancer
5295 (PIK3R1)
05222 Small cell lung cancer
5295 (PIK3R1)
05223 Non-small cell lung cancer
5295 (PIK3R1)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
5295 (PIK3R1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
5295 (PIK3R1)
04932 Non-alcoholic fatty liver disease (NAFLD)
5295 (PIK3R1)
04931 Insulin resistance
5295 (PIK3R1)
04933 AGE-RAGE signaling pathway in diabetic complications
5295 (PIK3R1)
09171 Infectious disease: bacterial
05131 Shigellosis
5295 (PIK3R1)
05135 Yersinia infection
5295 (PIK3R1)
05100 Bacterial invasion of epithelial cells
5295 (PIK3R1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
5295 (PIK3R1)
05170 Human immunodeficiency virus 1 infection
5295 (PIK3R1)
05162 Measles
5295 (PIK3R1)
05164 Influenza A
5295 (PIK3R1)
05161 Hepatitis B
5295 (PIK3R1)
05160 Hepatitis C
5295 (PIK3R1)
05168 Herpes simplex virus 1 infection
5295 (PIK3R1)
05163 Human cytomegalovirus infection
5295 (PIK3R1)
05167 Kaposi sarcoma-associated herpesvirus infection
5295 (PIK3R1)
05169 Epstein-Barr virus infection
5295 (PIK3R1)
05165 Human papillomavirus infection
5295 (PIK3R1)
09174 Infectious disease: parasitic
05146 Amoebiasis
5295 (PIK3R1)
05142 Chagas disease (American trypanosomiasis)
5295 (PIK3R1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
5295 (PIK3R1)
01524 Platinum drug resistance
5295 (PIK3R1)
01522 Endocrine resistance
5295 (PIK3R1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
5295 (PIK3R1)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
5295 (PIK3R1)
SSDB
Motif
Pfam:
PI3K_P85_iSH2
SH2
RhoGAP
SH3_1
SH3_9
SH3_2
Laminin_I
Lant_dehydr_C
DUF4201
PI_PP_I
Mod_r
Transcrip_act
Other DBs
NCBI-GeneID:
5295
NCBI-ProteinID:
NP_852664
OMIM:
171833
HGNC:
8979
Ensembl:
ENSG00000145675
Vega:
OTTHUMG00000131251
Pharos:
P27986
(Tchem)
UniProt:
P27986
A0A2X0SFG1
LinkDB
Structure
PDB:
5GJI
5AUL
3I5R
1H9O
2IUG
1PBW
1PHT
4JPS
6PYR
4WAF
2IUI
5UK8
5FI4
4L23
6PYU
5XGI
4L1B
4ZOP
5VLR
5UKJ
4L2Y
3HHM
5UBT
5M6U
4OVU
5XGH
5XGJ
5UL1
3I5S
5ITD
2RD0
5SWG
5SXB
5SW8
3HIZ
5SWR
6NCT
5SXA
5SXI
5SWP
5SXJ
5SXF
5SX8
5SWT
5SXD
5SWO
4OVV
4A55
5SXE
5SX9
5SXC
5SXK
2V1Y
2IUH
1PIC
1PKS
1PKT
Position
5q13.1
AA seq
724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq
2175 nt
+upstream
nt +downstream
nt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaggaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttacgtagaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccggccacctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagtttgcccctcctgacattgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacctggcagaa
ttacgacagcttcttgattgtgatacaccctccgtggacttggaaatgatcgatgtgcac
gttttggctgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctccagaagtacaaagctccgaagaatatatt
cagctattgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacctactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagacgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcagttct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaaattg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
cgagaatatgatagattatatgaagaatatacccgcacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacc
caagagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcactggtggaagatgatgaagatttgccccatcatgat
gagaagacatggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctatgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcaactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctcccttgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga
DBGET
integrated database retrieval system
