KEGG   Homo sapiens (human): 5465
Entry
5465              CDS       T01001                                 
Symbol
PPARA, NR1C1, PPAR, PPAR-alpha, PPARalpha, hPPAR
Name
(RefSeq) peroxisome proliferator activated receptor alpha
  KO
K07294  peroxisome proliferator-activated receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa03320  PPAR signaling pathway
hsa04024  cAMP signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04922  Glucagon signaling pathway
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04936  Alcoholic liver disease
hsa05160  Hepatitis C
hsa05207  Chemical carcinogenesis - receptor activation
hsa05415  Diabetic cardiomyopathy
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
  Element
N00529  HCV core to RXRA/PPARA-mediated transcription
Drug target
Aleglitazar: D08845
Bezafibrate: D01366<JP>
Carfloglitazar: D12484
Choline fenofibrate: D08890<US>
Ciprofibrate: D03521
Clofibrate (DG00358): D00279<JP> D01208 D07724
Elafibranor: D11208<US>
Etofibrate: D07187
Fenofibrate: D00565<JP/US>
Fenofibric acid: D11579
Gemfibrozil: D00334<US>
Indeglitazar: D09350
Muraglitazar: D05091
Naveglitazar: D08949
Peliglitazar: D05397
Pemafibrate: D10711<JP>
Saroglitazar (DG03333): D13044 D13045
Sodelglitazar: D06647
Tesaglitazar: D01274
Theofibrate: D06102
Trisdecanoin: D12614
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    5465 (PPARA)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    5465 (PPARA)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    5465 (PPARA)
  09172 Infectious disease: viral
   05160 Hepatitis C
    5465 (PPARA)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    5465 (PPARA)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    5465 (PPARA)
   04932 Non-alcoholic fatty liver disease
    5465 (PPARA)
   04931 Insulin resistance
    5465 (PPARA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5465 (PPARA)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    5465 (PPARA)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    5465 (PPARA)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1C. Peroxisome proliferator-activated receptor (PPAR)
   5465 (PPARA)
SSDB
Motif
Pfam: zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 5465
NCBI-ProteinID: NP_001001928
OMIM: 170998
HGNC: 9232
Ensembl: ENSG00000186951
UniProt: Q07869 F1D8S4
Structure
LinkDB
Position
22:46150526..46243756
AA seq 468 aa
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
NT seq 1407 nt   +upstreamnt  +downstreamnt
atggtggacacggaaagcccactctgccccctctccccactcgaggccggcgatctagag
agcccgttatctgaagagttcctgcaagaaatgggaaacatccaagagatttcgcaatcc
atcggcgaggatagttctggaagctttggctttacggaataccagtatttaggaagctgt
cctggctcagatggctcggtcatcacggacacgctttcaccagcttcgagcccctcctcg
gtgacttatcctgtggtccccggcagcgtggacgagtctcccagtggagcattgaacatc
gaatgtagaatctgcggggacaaggcctcaggctatcattacggagtccacgcgtgtgaa
ggctgcaagggcttctttcggcgaacgattcgactcaagctggtgtatgacaagtgcgac
cgcagctgcaagatccagaaaaagaacagaaacaaatgccagtattgtcgatttcacaag
tgcctttctgtcgggatgtcacacaacgcgattcgttttggacgaatgccaagatctgag
aaagcaaaactgaaagcagaaattcttacctgtgaacatgacatagaagattctgaaact
gcagatctcaaatctctggccaagagaatctacgaggcctacttgaagaacttcaacatg
aacaaggtcaaagcccgggtcatcctctcaggaaaggccagtaacaatccaccttttgtc
atacatgatatggagacactgtgtatggctgagaagacgctggtggccaagctggtggcc
aatggcatccagaacaaggaggcggaggtccgcatctttcactgctgccagtgcacgtca
gtggagaccgtcacggagctcacggaattcgccaaggccatcccaggcttcgcaaacttg
gacctgaacgatcaagtgacattgctaaaatacggagtttatgaggccatattcgccatg
ctgtcttctgtgatgaacaaagacgggatgctggtagcgtatggaaatgggtttataact
cgtgaattcctaaaaagcctaaggaaaccgttctgtgatatcatggaacccaagtttgat
tttgccatgaagttcaatgcactggaactggatgacagtgatatctccctttttgtggct
gctatcatttgctgtggagatcgtcctggccttctaaacgtaggacacattgaaaaaatg
caggagggtattgtacatgtgctcagactccacctgcagagcaaccacccggacgatatc
tttctcttcccaaaacttcttcaaaaaatggcagacctccggcagctggtgacggagcat
gcgcagctggtgcagatcatcaagaagacggagtcggatgctgcgctgcacccgctactg
caggagatctacagggacatgtactga

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