Homo sapiens (human): 558
Entry
558 CDS
T01001
Gene name
AXL, ARK, JTK11, Tyro7, UFO
Definition
(RefSeq) AXL receptor tyrosine kinase
KO
K05115
AXL receptor tyrosine kinase [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
Drug target
Amuvatinib (
DG01916
):
D09864
D09865
Bemcentinib:
D11438
Cabozantinib (
DG01670
):
D10062
D10095
Dubermatinib (
DG03093
):
D11732
D11733
Merestinib:
D11763
Sitravatinib (
DG03045
):
D11140
D11541
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
558 (AXL)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
558 (AXL)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
558 (AXL)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
AXL family
558 (AXL)
SSDB
Motif
Pfam:
Pkinase_Tyr
Pkinase
fn3
Ig_3
Ig_2
I-set
ig
V-set
C2-set_2
DUF4381
C1-set
DUF2627
Other DBs
NCBI-GeneID:
558
NCBI-ProteinID:
NP_068713
OMIM:
109135
HGNC:
905
Ensembl:
ENSG00000167601
Vega:
OTTHUMG00000182727
Pharos:
P30530
(Tchem)
UniProt:
P30530
LinkDB
Structure
PDB:
5VXZ
5U6B
4RA0
2C5D
Position
19q13.2
AA seq
894 aa
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
NT seq
2685 nt
+upstream
nt +downstream
nt
atggcgtggcggtgccccaggatgggcagggtcccgctggcctggtgcttggcgctgtgc
ggctgggcgtgcatggcccccaggggcacgcaggctgaagaaagtcccttcgtgggcaac
ccagggaatatcacaggtgcccggggactcacgggcacccttcggtgtcagctccaggtt
cagggagagccccccgaggtacattggcttcgggatggacagatcctggagctcgcggac
agcacccagacccaggtgcccctgggtgaggatgaacaggatgactggatagtggtcagc
cagctcagaatcacctccctgcagctttccgacacgggacagtaccagtgtttggtgttt
ctgggacatcagaccttcgtgtcccagcctggctatgttgggctggagggcttgccttac
ttcctggaggagcccgaagacaggactgtggccgccaacacccccttcaacctgagctgc
caagctcagggacccccagagcccgtggacctactctggctccaggatgctgtccccctg
gccacggctccaggtcacggcccccagcgcagcctgcatgttccagggctgaacaagaca
tcctctttctcctgcgaagcccataacgccaagggggtcaccacatcccgcacagccacc
atcacagtgctcccccagcagccccgtaacctccacctggtctcccgccaacccacggag
ctggaggtggcttggactccaggcctgagcggcatctaccccctgacccactgcaccctg
caggctgtgctgtcagacgatgggatgggcatccaggcgggagaaccagaccccccagag
gagcccctcacctcgcaagcatccgtgcccccccatcagcttcggctaggcagcctccat
cctcacaccccttatcacatccgcgtggcatgcaccagcagccagggcccctcatcctgg
acccactggcttcctgtggagacgccggagggagtgcccctgggcccccctgagaacatt
agtgctacgcggaatgggagccaggccttcgtgcattggcaagagccccgggcgcccctg
cagggtaccctgttagggtaccggctggcgtatcaaggccaggacaccccagaggtgcta
atggacatagggctaaggcaagaggtgaccctggagctgcagggggacgggtctgtgtcc
aatctgacagtgtgtgtggcagcctacactgctgctggggatggaccctggagcctccca
gtacccctggaggcctggcgcccagggcaagcacagccagtccaccagctggtgaaggaa
ccttcaactcctgccttctcgtggccctggtggtatgtactgctaggagcagtcgtggcc
gctgcctgtgtcctcatcttggctctcttccttgtccaccggcgaaagaaggagacccgt
tatggagaagtgtttgaaccaacagtggaaagaggtgaactggtagtcaggtaccgcgtg
cgcaagtcctacagtcgtcggaccactgaagctaccttgaacagcctgggcatcagtgaa
gagctgaaggagaagctgcgggatgtgatggtggaccggcacaaggtggccctggggaag
actctgggagagggagagtttggagctgtgatggaaggccagctcaaccaggacgactcc
atcctcaaggtggctgtgaagacgatgaagattgccatctgcacgaggtcagagctggag
gatttcctgagtgaagcggtctgcatgaaggaatttgaccatcccaacgtcatgaggctc
atcggtgtctgtttccagggttctgaacgagagagcttcccagcacctgtggtcatctta
cctttcatgaaacatggagacctacacagcttcctcctctattcccggctcggggaccag
ccagtgtacctgcccactcagatgctagtgaagttcatggcagacatcgccagtggcatg
gagtatctgagtaccaagagattcatacaccgggacctggcggccaggaactgcatgctg
aatgagaacatgtccgtgtgtgtggcggacttcgggctctccaagaagatctacaatggg
gactactaccgccagggacgtatcgccaagatgccagtcaagtggattgccattgagagt
ctagctgaccgtgtctacaccagcaagagcgatgtgtggtccttcggggtgacaatgtgg
gagattgccacaagaggccaaaccccatatccgggcgtggagaacagcgagatttatgac
tatctgcgccagggaaatcgcctgaagcagcctgcggactgtctggatggactgtatgcc
ttgatgtcgcggtgctgggagctaaatccccaggaccggccaagttttacagagctgcgg
gaagatttggagaacacactgaaggccttgcctcctgcccaggagcctgacgaaatcctc
tatgtcaacatggatgagggtggaggttatcctgaaccccctggagctgcaggaggagct
gaccccccaacccagccagaccctaaggattcctgtagctgcctcactgcggctgaggtc
catcctgctggacgctatgtcctctgcccttccacaacccctagccccgctcagcctgct
gataggggctccccagcagccccagggcaggaggatggtgcctga
DBGET
integrated database retrieval system
