Homo sapiens (human): 5600
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Entry
5600 CDS
T01001
Symbol
MAPK11, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta
Name
(RefSeq) mitogen-activated protein kinase 11
KO
K04441
p38 MAP kinase [EC:
2.7.11.24
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa04010
MAPK signaling pathway
hsa04015
Rap1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04114
Oocyte meiosis
hsa04148
Efferocytosis
hsa04218
Cellular senescence
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04370
VEGF signaling pathway
hsa04380
Osteoclast differentiation
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04611
Platelet activation
hsa04613
Neutrophil extracellular trap formation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04668
TNF signaling pathway
hsa04670
Leukocyte transendothelial migration
hsa04714
Thermogenesis
hsa04722
Neurotrophin signaling pathway
hsa04723
Retrograde endocannabinoid signaling
hsa04728
Dopaminergic synapse
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04912
GnRH signaling pathway
hsa04914
Progesterone-mediated oocyte maturation
hsa04917
Prolactin signaling pathway
hsa04926
Relaxin signaling pathway
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04935
Growth hormone synthesis, secretion and action
hsa04936
Alcoholic liver disease
hsa05014
Amyotrophic lateral sclerosis
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05163
Human cytomegalovirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05205
Proteoglycans in cancer
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415
Diabetic cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06180
Pathogenic Escherichia coli
nt06182
Shigella
nt06183
Yersinia
nt06263
Hepatocellular carcinoma
nt06517
TLR signaling
nt06535
Efferocytosis
Element
N00438
TLR2/4-MAPK signaling pathway
N01283
Shigella OspF to TLR2/4-MAPK signaling pathway
N01776
CaMK2-p38-MK2-ALOX5 pathway
Drug target
Dilmapimod (
DG01409
):
D09602
D09603
Doramapimod:
D03736
Losmapimod:
D09639
Neflamapimod:
D10959
Ralimetinib (
DG01847
):
D10658
D10659
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5600 (MAPK11)
04015 Rap1 signaling pathway
5600 (MAPK11)
04370 VEGF signaling pathway
5600 (MAPK11)
04668 TNF signaling pathway
5600 (MAPK11)
04068 FoxO signaling pathway
5600 (MAPK11)
04071 Sphingolipid signaling pathway
5600 (MAPK11)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
5600 (MAPK11)
09143 Cell growth and death
04114 Oocyte meiosis
5600 (MAPK11)
04218 Cellular senescence
5600 (MAPK11)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
5600 (MAPK11)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
5600 (MAPK11)
04613 Neutrophil extracellular trap formation
5600 (MAPK11)
04620 Toll-like receptor signaling pathway
5600 (MAPK11)
04621 NOD-like receptor signaling pathway
5600 (MAPK11)
04622 RIG-I-like receptor signaling pathway
5600 (MAPK11)
04625 C-type lectin receptor signaling pathway
5600 (MAPK11)
04660 T cell receptor signaling pathway
5600 (MAPK11)
04658 Th1 and Th2 cell differentiation
5600 (MAPK11)
04659 Th17 cell differentiation
5600 (MAPK11)
04657 IL-17 signaling pathway
5600 (MAPK11)
04664 Fc epsilon RI signaling pathway
5600 (MAPK11)
04670 Leukocyte transendothelial migration
5600 (MAPK11)
09152 Endocrine system
04912 GnRH signaling pathway
5600 (MAPK11)
04914 Progesterone-mediated oocyte maturation
5600 (MAPK11)
04917 Prolactin signaling pathway
5600 (MAPK11)
04926 Relaxin signaling pathway
5600 (MAPK11)
04935 Growth hormone synthesis, secretion and action
5600 (MAPK11)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
5600 (MAPK11)
09156 Nervous system
04728 Dopaminergic synapse
5600 (MAPK11)
04723 Retrograde endocannabinoid signaling
5600 (MAPK11)
04722 Neurotrophin signaling pathway
5600 (MAPK11)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
5600 (MAPK11)
09158 Development and regeneration
04380 Osteoclast differentiation
5600 (MAPK11)
09159 Environmental adaptation
04714 Thermogenesis
5600 (MAPK11)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
5600 (MAPK11)
05208 Chemical carcinogenesis - reactive oxygen species
5600 (MAPK11)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5600 (MAPK11)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
5600 (MAPK11)
05161 Hepatitis B
5600 (MAPK11)
05171 Coronavirus disease - COVID-19
5600 (MAPK11)
05163 Human cytomegalovirus infection
5600 (MAPK11)
05167 Kaposi sarcoma-associated herpesvirus infection
5600 (MAPK11)
05169 Epstein-Barr virus infection
5600 (MAPK11)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
5600 (MAPK11)
05130 Pathogenic Escherichia coli infection
5600 (MAPK11)
05132 Salmonella infection
5600 (MAPK11)
05131 Shigellosis
5600 (MAPK11)
05135 Yersinia infection
5600 (MAPK11)
05133 Pertussis
5600 (MAPK11)
05152 Tuberculosis
5600 (MAPK11)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
5600 (MAPK11)
05140 Leishmaniasis
5600 (MAPK11)
05142 Chagas disease
5600 (MAPK11)
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
5600 (MAPK11)
05020 Prion disease
5600 (MAPK11)
05022 Pathways of neurodegeneration - multiple diseases
5600 (MAPK11)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5600 (MAPK11)
05418 Fluid shear stress and atherosclerosis
5600 (MAPK11)
05415 Diabetic cardiomyopathy
5600 (MAPK11)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
5600 (MAPK11)
04932 Non-alcoholic fatty liver disease
5600 (MAPK11)
04933 AGE-RAGE signaling pathway in diabetic complications
5600 (MAPK11)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
5600 (MAPK11)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
5600 (MAPK11)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.24 mitogen-activated protein kinase
5600 (MAPK11)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: CMGC group
MAPK family [OT]
5600 (MAPK11)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Kdo
APH
RIO1
Cas_CT1975
Motif
Other DBs
NCBI-GeneID:
5600
NCBI-ProteinID:
NP_002742
OMIM:
602898
HGNC:
6873
Ensembl:
ENSG00000185386
UniProt:
Q15759
Structure
PDB
LinkDB
All DBs
Position
22:complement(50263713..50270380)
Genome browser
AA seq
364 aa
AA seq
DB search
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
NT seq
1095 nt
NT seq
+upstream
nt +downstream
nt
atgtcgggccctcgcgccggcttctaccggcaggagctgaacaagaccgtgtgggaggtg
ccgcagcggctgcaggggctgcgcccggtgggctccggcgcctacggctccgtctgttcg
gcctacgacgcccggctgcgccagaaggtggcggtgaagaagctgtcgcgccccttccag
tcgctgatccacgcgcgcagaacgtaccgggagctgcggctgctcaagcacctgaagcac
gagaacgtcatcgggcttctggacgtcttcacgccggccacgtccatcgaggacttcagc
gaagtgtacttggtgaccaccctgatgggcgccgacctgaacaacatcgtcaagtgccag
gcgctgagcgacgagcacgttcaattcctggtttaccagctgctgcgcgggctgaagtac
atccactcggccgggatcatccaccgggacctgaagcccagcaacgtggctgtgaacgag
gactgtgagctcaggatcctggattttgggctggcgcgccaggcggacgaggagatgacc
ggctatgtggccacgcgctggtaccgggcacctgagatcatgctcaactggatgcattac
aaccaaacagtggatatctggtccgtgggctgcatcatggctgagctgctccagggcaag
gccctcttcccgggaagcgactacattgaccagctgaagcgcatcatggaagtggtgggc
acacccagccctgaggttctggcaaaaatctcctcagaacacgcccggacatatatccag
tccctgccccccatgccccagaaggacctgagcagcatcttccgtggagccaaccccctg
gccatagacctccttggaaggatgctggtgctggacagtgaccagagggtcagtgcagct
gaggcactggcccacgcctacttcagccagtaccacgaccccgaggatgagccagaggcc
gagccatatgatgagagcgttgaggccaaggagcgcacgctggaggagtggaaggagctc
acttaccaggaagtcctcagcttcaagcccccagagccaccgaagccacctggcagcctg
gagattgagcagtga
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integrated database retrieval system
