KEGG   Homo sapiens (human): 5728Help
Entry
5728              CDS       T01001                                 

Gene name
PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1
Definition
(RefSeq) phosphatase and tensin homolog
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04115  p53 signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04510  Focal adhesion
hsa04931  Insulin resistance
hsa05161  Hepatitis B
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05222  Small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05230  Central carbon metabolism in cancer
Network
N00051  Deleted PTEN to PI3K signaling pathway
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00193  HPV E6 to host-cell-protein inhibition
N00220  PTEN-PIP3-AKT signaling pathway
Disease
H00013  Small cell lung cancer
H00024  Prostate cancer
H00026  Endometrial cancer
H00029  Vulvar cancer
H00031  Breast cancer
H00038  Melanoma
H00042  Glioma
H00048  Hepatocellular carcinoma
H00539  PTEN hamartoma tumor syndrome (PHTS)
H01195  VACTERL/VATER association
H01222  Cowden syndrome
H01463  Mycosis fungoides
H01556  Meningioma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5728 (PTEN)
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    5728 (PTEN)
   04070 Phosphatidylinositol signaling system
    5728 (PTEN)
   04071 Sphingolipid signaling pathway
    5728 (PTEN)
   04151 PI3K-Akt signaling pathway
    5728 (PTEN)
   04150 mTOR signaling pathway
    5728 (PTEN)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    5728 (PTEN)
  Cell growth and death
   04115 p53 signaling pathway
    5728 (PTEN)
   04218 Cellular senescence
    5728 (PTEN)
  Cellular community - eukaryotes
   04510 Focal adhesion
    5728 (PTEN)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5728 (PTEN)
   05230 Central carbon metabolism in cancer
    5728 (PTEN)
   05206 MicroRNAs in cancer
    5728 (PTEN)
   05225 Hepatocellular carcinoma
    5728 (PTEN)
   05214 Glioma
    5728 (PTEN)
   05218 Melanoma
    5728 (PTEN)
   05215 Prostate cancer
    5728 (PTEN)
   05213 Endometrial cancer
    5728 (PTEN)
   05224 Breast cancer
    5728 (PTEN)
   05222 Small cell lung cancer
    5728 (PTEN)
  Endocrine and metabolic diseases
   04931 Insulin resistance
    5728 (PTEN)
  Infectious diseases
   05161 Hepatitis B
    5728 (PTEN)
   05165 Human papillomavirus infection
    5728 (PTEN)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    5728 (PTEN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5728 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     5728 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     5728 (PTEN)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    5728 (PTEN)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PTEN_C2 DSPc Y_phosphatase Y_phosphatase3 PTPlike_phytase DUF3256
Motif
Other DBs
NCBI-GeneID: 5728
NCBI-ProteinID: NP_000305
OMIM: 601728
HGNC: 9588
Ensembl: ENSG00000171862
Vega: OTTHUMG00000018688
Pharos: P60484(Tbio)
UniProt: P60484 F6KD01
LinkDB All DBs
Structure
PDB: 

Position
10q23.31
AA seq 403 aa AA seqDB search
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
NT seq 1212 nt NT seq  +upstreamnt  +downstreamnt
atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaagaggatgga
ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa
agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag
cataaaaaccattacaagatatacaatctttgtgctgaaagacattatgacaccgccaaa
tttaattgcagagttgcacaatatccttttgaagaccataacccaccacagctagaactt
atcaaacccttttgtgaagatcttgaccaatggctaagtgaagatgacaatcatgttgca
gcaattcactgtaaagctggaaagggacgaactggtgtaatgatatgtgcatatttatta
catcggggcaaatttttaaaggcacaagaggccctagatttctatggggaagtaaggacc
agagacaaaaagggagtaactattcccagtcagaggcgctatgtgtattattatagctac
ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt
gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagcta
aaggtgaagatatattcctccaattcaggacccacacgacgggaagacaagttcatgtac
tttgagttccctcagccgttacctgtgtgtggtgatatcaaagtagagttcttccacaaa
cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaatacattcttcata
ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctatgtgatcaagaaatc
gatagcatttgcagtatagagcgtgcagataatgacaaggaatatctagtacttacttta
acaaaaaatgatcttgacaaagcaaataaagacaaagccaaccgatacttttctccaaat
tttaaggtgaagctgtacttcacaaaaacagtagaggagccgtcaaatccagaggctagc
agttcaacttctgtaacaccagatgttagtgacaatgaacctgatcattatagatattct
gacaccactgactctgatccagagaatgaaccttttgatgaagatcagcatacacaaatt
acaaaagtctga

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