Homo sapiens (human): 5740
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Entry
5740 CDS
T01001
Gene name
PTGIS, CYP8, CYP8A1, PGIS, PTGI
Definition
(RefSeq) prostaglandin I2 synthase
KO
K01831
prostacyclin synthase [EC:
5.3.99.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00590
Arachidonic acid metabolism
hsa01100
Metabolic pathways
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00590 Arachidonic acid metabolism
5740 (PTGIS)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:
hsa00199
]
5740 (PTGIS)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.99 Other intramolecular oxidoreductases
5.3.99.4 prostaglandin-I synthase
5740 (PTGIS)
Cytochrome P450 [BR:
hsa00199
]
Cytochrome P450, animal type
CYP8 family
5740 (PTGIS)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
p450
Motif
Other DBs
NCBI-GeneID:
5740
NCBI-ProteinID:
NP_000952
OMIM:
601699
HGNC:
9603
Ensembl:
ENSG00000124212
Vega:
OTTHUMG00000033077
Pharos:
Q16647
(Tbio)
UniProt:
Q16647
LinkDB
All DBs
Structure
PDB:
3B6H
2IAG
Thumbnails
Position
20q13.13
AA seq
500 aa
AA seq
DB search
MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK
HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE
KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL
YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL
LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL
KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE
VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF
YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR
YGFGLMQPEHDVPVRYRIRP
NT seq
1503 nt
NT seq
+upstream
nt +downstream
nt
atggcttgggccgcgctcctcggcctcctggccgcactgttgctgctgctgctactgagc
cgccgccgcacgcggcgacctggtgagcctcccctggacctgggcagcatcccctggttg
gggtatgccttggactttggaaaagatgctgccagcttcctcacgaggatgaaggagaag
cacggtgacatctttactatactggttgggggcaggtatgtcaccgttctcctggaccca
cactcctacgacgcggtggtgtgggagcctcgcaccaggctcgacttccatgcctatgcc
atcttcctcatggagaggatttttgatgtgcagcttccacattacagccccagtgatgaa
aaggccaggatgaaactgactcttctccacagagagctccaggcactcacagaagccatg
tataccaacctccatgcagtgctgttgggcgatgctacagaagcaggcagtggctggcac
gagatgggtctcctcgacttctcctacagcttcctgctcagagccggctacctgactctt
tacggaattgaggcgctgccacgcacccatgaaagccaggcccaggaccgcgtccactca
gctgatgtcttccacacctttcgccagctcgaccggctgctccccaaactggcccgtggc
tccctgtcagtgggggacaaggaccacatgtgcagtgtcaaaagtcgcctgtggaagctg
ctatccccagccaggctggccaggcgggcccaccggagcaaatggctggagagttacctg
ctgcacctggaggagatgggtgtgtcagaggagatgcaggcacgggccctggtgctgcag
ctgtgggccacacaggggaatatgggtcccgctgccttctggctcctgctcttccttctc
aagaatcctgaagccctggctgctgtccgcggagagctcgagagtatcctttggcaagcg
gagcagcctgtctcgcagacgaccactctcccacagaaggttctagacagcacacctgtg
cttgatagcgtgctgagtgagagcctcaggcttacagctgcccccttcatcacccgcgag
gttgtggtggacctggccatgcccatggcagacgggcgagaattcaacctgcgacgtggt
gaccgcctcctcctcttccccttcctgagcccccagagagacccagaaatctacacagac
ccagaggtatttaaatacaaccgattcctgaaccctgacggatcagagaagaaagacttt
tacaaggatgggaaacggctgaagaattacaacatgccctggggggcggggcacaatcac
tgcctggggaggagttatgcggtcaacagcatcaaacaatttgtgttccttgtgctggtg
cacttggacttggagctgatcaacgcagatgtggagatccctgagtttgacctcagcagg
tacggcttcggtctgatgcagccggaacacgacgtgcccgtccgctaccgcatccgccca
tga
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