KEGG   Homo sapiens (human): 5742
Entry
5742              CDS       T01001                                 

Gene name
PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Definition
(RefSeq) prostaglandin-endoperoxide synthase 1
  KO
K00509  prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa01100  Metabolic pathways
hsa04611  Platelet activation
hsa04726  Serotonergic synapse
hsa04923  Regulation of lipolysis in adipocytes
Drug target
Aceclofenac: D01545
Acemetacin: D01582<JP>
Acetylsalicylic acid (DG00015): D00109<JP> D05181 D07579 D07580 D07581 D07582
Alminoprofen: D01513
Aloxiprin: D07421
Amfenac (DG01249): D01788 D07443
Ampiroxicam: D01397<JP>
Amtolmetin guacil: D07453
Benzydamine (except lozenges) (DG00014): D01410 D07516 D07517
Bromfenac (DG01128): D03163<JP/US> D07541
Bufexamac: D01271
Carprofen: D03410
Choline salicylate: D00810
Dexibuprofen (DG00756): D03715 D03718
Dexketoprofen: D07269
Diclofenac (DG00441): D00903<US> D00904<JP/US> D07816<US> D07817 D07818<US> D07819
Droxicam: D07267
Epidihydrocholesterin: D01527
Etofenamate: D04102
Felbinac (DG00764): D01675<JP> D01841
Fenbufen: D01344
Fenoprofen (DG00754): D00968<US> D02350
Flufenamic acid (DG00757): D01581 D01823<JP> D03254<JP>
Flurbiprofen (DG00755): D00330<JP/US> D01475<JP> D02290<US> D10254
Glycol salicylate: D01557
Ibuprofen (DG00245): D00126<JP/US> D01122<JP> D04490 D06606<JP/US> D08058 D08059 D09760
Ibuproxam: D07268
Indobufen: D07141
Indometacin (DG00241): D00141<JP/US> D01565<JP> D02110<JP/US>
Ketoprofen (DG00753): D00132<JP/US> D08102 D08103
Ketorolac (DG00751): D00813<US> D08104
Lornoxicam: D01866<JP>
Loxoprofen (DG01251): D01709<JP> D08149
Magnesium salicylate: D00827
Meclofenamic acid (DG00758): D00169<US> D02341 D08162
Mefenamic acid: D00151<JP/US>
Mofezolac: D01718<JP>
Nabumetone: D00425<JP/US>
Naproxcinod: D09568
Naproxen (DG00455): D00118<JP/US> D00970<US> D10017
Nepafenac: D05143<JP/US>
Orpanoxin: D05275
Oxaprozin: D00463<JP/US>
Oxyphenbutazone (DG00746): D05319 D08324
Pamicogrel: D01090
Paracetamol: D00217<JP/US>
Phenbutazone sodium glycerate: D05451
Phenylbutazone (DG00745): D00510 D08363 D08364
Piketoprofen (DG01250): D08374 D08375
Piroxicam (DG00752): D00127<JP/US> D05511 D05512 D05513
Pranoprofen: D01578<JP>
Pravadoline maleate: D05598
Proglumetacin (DG00750): D01765<JP> D08427
Propacetamol (DG00828): D07294 D08434
Salicylamide: D01811
Salicylate meglumine: D05791
Salsalate: D00428
Sodium salicylate: D00566<JP>
Sulindac: D00120<JP/US>
Tebufelone: D06017
Tenidap (DG00761): D06072 D06073
Tenoxicam: D01767
Tiaprofenic acid: D01325<JP>
Tolfenamic acid: D01183
Tolmetin (DG00747): D00158<US> D02355
Triflusal: D07142
Trolamine: D08501
Zaltoprofen: D01547<JP>
Zidometacin: D06364
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    5742 (PTGS1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5742 (PTGS1)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    5742 (PTGS1)
  09156 Nervous system
   04726 Serotonergic synapse
    5742 (PTGS1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     5742 (PTGS1)
SSDB
Motif
Pfam: An_peroxidase EGF EGF_2
Other DBs
NCBI-GeneID: 5742
NCBI-ProteinID: NP_000953
OMIM: 176805
HGNC: 9604
Ensembl: ENSG00000095303
Vega: OTTHUMG00000020605
Pharos: P23219(Tclin)
UniProt: P23219
LinkDB
Position
9q33.2
AA seq 599 aa
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
NT seq 1800 nt   +upstreamnt  +downstreamnt
atgagccggagtctcttgctctggttcttgctgttcctgctcctgctcccgccgctcccc
gtcctgctcgcggacccaggggcgcccacgccagtgaatccctgttgttactatccatgc
cagcaccagggcatctgtgtccgcttcggccttgaccgctaccagtgtgactgcacccgc
acgggctattccggccccaactgcaccatccctggcctgtggacctggctccggaattca
ctgcggcccagcccctctttcacccacttcctgctcactcacgggcgctggttctgggag
tttgtcaatgccaccttcatccgagagatgctcatgcgcctggtactcacagtgcgctcc
aaccttatccccagtccccccacctacaactcagcacatgactacatcagctgggagtct
ttctccaacgtgagctattacactcgtattctgccctctgtgcctaaagattgccccaca
cccatgggaaccaaagggaagaagcagttgccagatgcccagctcctggcccgccgcttc
ctgctcaggaggaagttcatacctgacccccaaggcaccaacctcatgtttgccttcttt
gcacaacacttcacccaccagttcttcaaaacttctggcaagatgggtcctggcttcacc
aaggccttgggccatggggtagacctcggccacatttatggagacaatctggagcgtcag
tatcaactgcggctctttaaggatgggaaactcaagtaccaggtgctggatggagaaatg
tacccgccctcggtagaagaggcgcctgtgttgatgcactacccccgaggcatcccgccc
cagagccagatggctgtgggccaggaggtgtttgggctgcttcctgggctcatgctgtat
gccacgctctggctacgtgagcacaaccgtgtgtgtgacctgctgaaggctgagcacccc
acctggggcgatgagcagcttttccagacgacccgcctcatcctcataggggagaccatc
aagattgtcatcgaggagtacgtgcagcagctgagtggctatttcctgcagctgaaattt
gacccagagctgctgttcggtgtccagttccaataccgcaaccgcattgccatggagttc
aaccatctctaccactggcaccccctcatgcctgactccttcaaggtgggctcccaggag
tacagctacgagcagttcttgttcaacacctccatgttggtggactatggggttgaggcc
ctggtggatgccttctctcgccagattgctggccggatcggtgggggcaggaacatggac
caccacatcctgcatgtggctgtggatgtcatcagggagtctcgggagatgcggctgcag
cccttcaatgagtaccgcaagaggtttggcatgaaaccctacacctccttccaggagctc
gtaggagagaaggagatggcagcagagttggaggaattgtatggagacattgatgcgttg
gagttctaccctggactgcttcttgaaaagtgccatccaaactctatctttggggagagt
atgatagagattggggctcccttttccctcaagggtctcctagggaatcccatctgttct
ccggagtactggaagccgagcacatttggcggcgaggtgggctttaacattgtcaagacg
gccacactgaagaagctggtctgcctcaacaccaagacctgtccctacgtttccttccgt
gtgccggatgccagtcaggatgatgggcctgctgtggagcgaccatccacagagctctga

KEGG   Homo sapiens (human): 5743
Entry
5743              CDS       T01001                                 

Gene name
PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Definition
(RefSeq) prostaglandin-endoperoxide synthase 2
  KO
K11987  prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa01100  Metabolic pathways
hsa04064  NF-kappa B signaling pathway
hsa04370  VEGF signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04668  TNF signaling pathway
hsa04723  Retrograde endocannabinoid signaling
hsa04726  Serotonergic synapse
hsa04913  Ovarian steroidogenesis
hsa04921  Oxytocin signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05140  Leishmaniasis
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis
hsa05206  MicroRNAs in cancer
hsa05222  Small cell lung cancer
Network
nt06124  Chemokine signaling (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06167  Human cytomegalovirus (HCMV)
  Element
N00402  HCMV US28 to GNAQ-PLCB/G-calcineurin signaling pathway
Disease
H00017  Esophageal cancer
H00025  Penile cancer
H00046  Cholangiocarcinoma
Drug target
Aceclofenac: D01545
Acemetacin: D01582<JP>
Acetylsalicylic acid (DG00015): D00109<JP> D05181 D07579 D07580 D07581 D07582
Alclofenac: D01252
Alminoprofen: D01513
Aloxiprin: D07421
Amfenac (DG01249): D01788 D07443
Ampiroxicam: D01397<JP>
Amtolmetin guacil: D07453
Apricoxib: D08657
Benzydamine (except lozenges) (DG00014): D01410 D07516 D07517
Bromfenac (DG01128): D03163<JP/US> D07541
Bufexamac: D01271
Carprofen: D03410
Celecoxib: D00567<JP/US>
Choline salicylate: D00810
Darbufelone mesylate: D03652
Deracoxib: D03689
Dexibuprofen (DG00756): D03715 D03718
Dexketoprofen: D07269
Diclofenac (DG00441): D00903<US> D00904<JP/US> D07816<US> D07817 D07818<US> D07819
Diflunisal: D00130<US>
Droxicam: D07267
Eltenac: D07888
Etodolac: D00315<JP/US>
Etofenamate: D04102
Etoricoxib: D03710
Felbinac (DG00764): D01675<JP> D01841
Fenbufen: D01344
Fenoprofen (DG00754): D00968<US> D02350
Firocoxib: D03712
Flufenamic acid (DG00757): D01581 D01823<JP> D03254<JP>
Flurbiprofen (DG00755): D00330<JP/US> D01475<JP> D02290<US> D10254
Glycol salicylate: D01557
Ibuprofen (DG00245): D00126<JP/US> D01122<JP> D04490 D06606<JP/US> D08058 D08059 D09760
Ibuproxam: D07268
Indobufen: D07141
Indometacin (DG00241): D00141<JP/US> D01565<JP> D02110<JP/US>
Ketoprofen (DG00753): D00132<JP/US> D08102 D08103
Ketorolac (DG00751): D00813<US> D08104
Lornoxicam: D01866<JP>
Loxoprofen (DG01251): D01709<JP> D08149
Lumiracoxib: D03714
Magnesium salicylate: D00827
Mavacoxib: D04863
Meclofenamic acid (DG00758): D00169<US> D02341 D08162
Mefenamic acid: D00151<JP/US>
Meloxicam: D00969<JP/US>
Nabumetone: D00425<JP/US>
Naproxcinod: D09568
Naproxen (DG00455): D00118<JP/US> D00970<US> D10017
Nepafenac: D05143<JP/US>
Niflumic acid: D08275
Nimesulide: D01049
Orpanoxin: D05275
Oxaprozin: D00463<JP/US>
Oxyphenbutazone (DG00746): D05319 D08324
Pamicogrel: D01090
Paracetamol: D00217<JP/US>
Parecoxib (DG00759): D03716 D03717
Phenbutazone sodium glycerate: D05451
Phenylbutazone (DG00745): D00510 D08363 D08364
Piketoprofen (DG01250): D08374 D08375
Piroxicam (DG00752): D00127<JP/US> D05511 D05512 D05513
Polmacoxib: D10656
Pranoprofen: D01578<JP>
Pravadoline maleate: D05598
Proglumetacin (DG00750): D01765<JP> D08427
Propacetamol (DG00828): D07294 D08434
Rofecoxib: D00568
Salicylamide: D01811
Salicylate meglumine: D05791
Salsalate: D00428
Sodium salicylate: D00566<JP>
Sulindac: D00120<JP/US>
Tebufelone: D06017
Tenidap (DG00761): D06072 D06073
Tenoxicam: D01767
Tiaprofenic acid: D01325<JP>
Tilmacoxib: D01974
Tolfenamic acid: D01183
Tolmetin (DG00747): D00158<US> D02355
Trolamine: D08501
Valdecoxib: D02709
Zaltoprofen: D01547<JP>
Zidometacin: D06364
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    5743 (PTGS2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    5743 (PTGS2)
   04064 NF-kappa B signaling pathway
    5743 (PTGS2)
   04668 TNF signaling pathway
    5743 (PTGS2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    5743 (PTGS2)
   04657 IL-17 signaling pathway
    5743 (PTGS2)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    5743 (PTGS2)
   04913 Ovarian steroidogenesis
    5743 (PTGS2)
   04921 Oxytocin signaling pathway
    5743 (PTGS2)
  09156 Nervous system
   04726 Serotonergic synapse
    5743 (PTGS2)
   04723 Retrograde endocannabinoid signaling
    5743 (PTGS2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5743 (PTGS2)
   05206 MicroRNAs in cancer
    5743 (PTGS2)
   05204 Chemical carcinogenesis
    5743 (PTGS2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    5743 (PTGS2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5743 (PTGS2)
   05022 Pathways of neurodegeneration - multiple diseases
    5743 (PTGS2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    5743 (PTGS2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5743 (PTGS2)
   05165 Human papillomavirus infection
    5743 (PTGS2)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    5743 (PTGS2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     5743 (PTGS2)
SSDB
Motif
Pfam: An_peroxidase EGF
Other DBs
NCBI-GeneID: 5743
NCBI-ProteinID: NP_000954
OMIM: 600262
HGNC: 9605
Ensembl: ENSG00000073756
Vega: OTTHUMG00000035473
Pharos: P35354(Tclin)
UniProt: P35354
LinkDB
Structure
PDB: 

Position
1q31.1
AA seq 604 aa
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
NT seq 1815 nt   +upstreamnt  +downstreamnt
atgctcgcccgcgccctgctgctgtgcgcggtcctggcgctcagccatacagcaaatcct
tgctgttcccacccatgtcaaaaccgaggtgtatgtatgagtgtgggatttgaccagtat
aagtgcgattgtacccggacaggattctatggagaaaactgctcaacaccggaatttttg
acaagaataaaattatttctgaaacccactccaaacacagtgcactacatacttacccac
ttcaagggattttggaacgttgtgaataacattcccttccttcgaaatgcaattatgagt
tatgtgttgacatccagatcacatttgattgacagtccaccaacttacaatgctgactat
ggctacaaaagctgggaagccttctctaacctctcctattatactagagcccttcctcct
gtgcctgatgattgcccgactcccttgggtgtcaaaggtaaaaagcagcttcctgattca
aatgagattgtggaaaaattgcttctaagaagaaagttcatccctgatccccagggctca
aacatgatgtttgcattctttgcccagcacttcacgcatcagtttttcaagacagatcat
aagcgagggccagctttcaccaacgggctgggccatggggtggacttaaatcatatttac
ggtgaaactctggctagacagcgtaaactgcgccttttcaaggatggaaaaatgaaatat
cagataattgatggagagatgtatcctcccacagtcaaagatactcaggcagagatgatc
taccctcctcaagtccctgagcatctacggtttgctgtggggcaggaggtctttggtctg
gtgcctggtctgatgatgtatgccacaatctggctgcgggaacacaacagagtatgcgat
gtgcttaaacaggagcatcctgaatggggtgatgagcagttgttccagacaagcaggcta
atactgataggagagactattaagattgtgattgaagattatgtgcaacacttgagtggc
tatcacttcaaactgaaatttgacccagaactacttttcaacaaacaattccagtaccaa
aatcgtattgctgctgaatttaacaccctctatcactggcatccccttctgcctgacacc
tttcaaattcatgaccagaaatacaactatcaacagtttatctacaacaactctatattg
ctggaacatggaattacccagtttgttgaatcattcaccaggcaaattgctggcagggtt
gctggtggtaggaatgttccacccgcagtacagaaagtatcacaggcttccattgaccag
agcaggcagatgaaataccagtcttttaatgagtaccgcaaacgctttatgctgaagccc
tatgaatcatttgaagaacttacaggagaaaaggaaatgtctgcagagttggaagcactc
tatggtgacatcgatgctgtggagctgtatcctgcccttctggtagaaaagcctcggcca
gatgccatctttggtgaaaccatggtagaagttggagcaccattctccttgaaaggactt
atgggtaatgttatatgttctcctgcctactggaagccaagcacttttggtggagaagtg
ggttttcaaatcatcaacactgcctcaattcagtctctcatctgcaataacgtgaagggc
tgtccctttacttcattcagtgttccagatccagagctcattaaaacagtcaccatcaat
gcaagttcttcccgctccggactagatgatatcaatcccacagtactactaaaagaacgt
tcgactgaactgtag

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