KEGG T01001: 5743

Homo sapiens (human): 5743

Entry

5743              CDS       T01001

Symbol

PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2

Name

(RefSeq) prostaglandin-endoperoxide synthase 2

K11987

prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa00590

Arachidonic acid metabolism

hsa01100

Metabolic pathways

hsa04064

NF-kappa B signaling pathway

hsa04370

VEGF signaling pathway

hsa04625

C-type lectin receptor signaling pathway

hsa04657

IL-17 signaling pathway

hsa04668

TNF signaling pathway

hsa04723

Retrograde endocannabinoid signaling

hsa04726

Serotonergic synapse

hsa04913

Ovarian steroidogenesis

hsa04921

Oxytocin signaling pathway

hsa04923

Regulation of lipolysis in adipocytes

hsa05010

Alzheimer disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05140

Leishmaniasis

hsa05163

Human cytomegalovirus infection

hsa05165

Human papillomavirus infection

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05200

Pathways in cancer

hsa05204

Chemical carcinogenesis - DNA adducts

hsa05206

MicroRNAs in cancer

hsa05222

Small cell lung cancer

Network

nt06124  Chemokine signaling (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06167  Human cytomegalovirus (HCMV)
nt06227  Nuclear receptor signaling
nt06360  Cushing syndrome

Element

N00317

AhR signaling pathway

N00402

HCMV US28 to GNAQ-PLCB/G-calcineurin signaling pathway

Disease

H00017

Esophageal cancer

H00025

Penile cancer

H00046

Cholangiocarcinoma

Drug target

Aceclofenac:

D01545

Acemetacin:

D01582<JP>

Acetylsalicylic acid (DG00015):

D00109<JP> D05181 D07579 D07580 D07581 D07582

Alclofenac:

Alminoprofen:

Aloxiprin:

Amfenac (DG01249):

Ampiroxicam:

D01397<JP>

Amtolmetin guacil:

D07453

Apricoxib:

D08657

Benzydamine (DG00014):

D01410 D07516 D07517

Bromfenac (DG01128):

D03163<JP/US> D07541

Bufexamac:

D01271

Carprofen:

D03410

Celecoxib:

D00567<JP/US>

Choline salicylate:

D00810

Darbufelone mesylate:

D03652

Deracoxib:

D03689

Dexibuprofen (DG00756):

D03715 D03718

Dexketoprofen:

D07269

Diclofenac (DG00441):

D00903<US> D00904<JP/US> D07816<US> D07817 D07818<US> D07819

Diclofenac etalhyaluronate (DG02959):

D11020<JP>

Diflunisal:

D00130<US>

Droxicam:

D07267

Eltenac:

D07888

Etodolac:

D00315<JP/US>

Etofenamate:

D04102

Etoricoxib:

D03710

Felbinac (DG00764):

D01675<JP> D01841

Fenbufen:

D01344

Fenoprofen (DG00754):

D00968<US> D02350

Firocoxib:

D03712

Flufenamic acid (DG00757):

D01581 D01823<JP> D03254<JP>

Flurbiprofen (DG00755):

D00330<JP/US> D01475<JP> D02290<US> D10254

Glycol salicylate:

D01557

Ibuprofen (DG00245):

D00126<JP/US> D01122<JP> D04490 D06606<JP/US> D08058 D08059 D09760

Ibuproxam:

D07268

Indobufen:

D07141

Indometacin (DG00241):

D00141<JP/US> D01565<JP> D02110<JP/US>

Ketoprofen (DG00753):

D00132<JP/US> D08102 D08103

Ketorolac (DG00751):

D00813<US> D08104

Lornoxicam:

D01866<JP>

Loxoprofen (DG01251):

D01709<JP> D08149

Lumiracoxib:

D03714

Magnesium salicylate:

D00827

Mavacoxib:

D04863

Meclofenamic acid (DG00758):

D00169<US> D02341 D08162

Mefenamic acid:

D00151<JP/US>

Meloxicam:

D00969<JP/US>

Nabumetone:

D00425<JP/US>

Naproxcinod:

D09568

Naproxen (DG00455):

D00118<JP/US> D00970<US> D10017

Nepafenac:

D05143<JP/US>

Niflumic acid:

D08275

Nimesulide:

D01049

Orpanoxin:

D05275

Oxaprozin:

D00463<JP/US>

Oxyphenbutazone (DG00746):

D05319 D08324

Pamicogrel:

D01090

Paracetamol:

D00217<JP/US>

Parecoxib (DG00759):

D03716 D03717

Phenbutazone sodium glycerate:

D05451

Phenylbutazone (DG00745):

D00510 D08363 D08364

Piketoprofen (DG01250):

D08374 D08375

Piroxicam (DG00752):

D00127<JP/US> D05511 D05512 D05513

Polmacoxib:

D10656

Pranoprofen:

D01578<JP>

Pravadoline maleate:

D05598

Proglumetacin (DG00750):

D01765<JP> D08427

Propacetamol (DG00828):

D07294 D08434

Rofecoxib:

D00568

Salicylamide:

D01811

Salicylate meglumine:

D05791

Salsalate:

D00428

Sodium salicylate:

D00566<JP>

Sulindac:

D00120<JP/US>

Tebufelone:

Tenidap (DG00761):

Tenoxicam:

Tiaprofenic acid:

Tilmacoxib:

Tolfenamic acid:

Tolmetin (DG00747):

Trolamine:

Valdecoxib:

Zaltoprofen:

D01547<JP>

Zidometacin:

D06364

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    5743 (PTGS2)
09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    5743 (PTGS2)
   04064 NF-kappa B signaling pathway
    5743 (PTGS2)
   04668 TNF signaling pathway
    5743 (PTGS2)
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    5743 (PTGS2)
   04657 IL-17 signaling pathway
    5743 (PTGS2)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    5743 (PTGS2)
   04913 Ovarian steroidogenesis
    5743 (PTGS2)
   04921 Oxytocin signaling pathway
    5743 (PTGS2)
  09156 Nervous system
   04726 Serotonergic synapse
    5743 (PTGS2)
   04723 Retrograde endocannabinoid signaling
    5743 (PTGS2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5743 (PTGS2)
   05206 MicroRNAs in cancer
    5743 (PTGS2)
   05204 Chemical carcinogenesis - DNA adducts
    5743 (PTGS2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    5743 (PTGS2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    5743 (PTGS2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5743 (PTGS2)
   05165 Human papillomavirus infection
    5743 (PTGS2)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    5743 (PTGS2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5743 (PTGS2)
   05022 Pathways of neurodegeneration - multiple diseases
    5743 (PTGS2)
Enzymes [BR:hsa01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     5743 (PTGS2)

SSDB

Motif

Pfam:

An_peroxidase EGF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P35354(Tclin)

UniProt:

P35354

Structure

LinkDB

Position

1:complement(186671791..186680423)

AA seq 604 aa
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL

NT seq 1815 nt +upstreamnt +downstreamnt
atgctcgcccgcgccctgctgctgtgcgcggtcctggcgctcagccatacagcaaatcct
tgctgttcccacccatgtcaaaaccgaggtgtatgtatgagtgtgggatttgaccagtat
aagtgcgattgtacccggacaggattctatggagaaaactgctcaacaccggaatttttg
acaagaataaaattatttctgaaacccactccaaacacagtgcactacatacttacccac
ttcaagggattttggaacgttgtgaataacattcccttccttcgaaatgcaattatgagt
tatgtgttgacatccagatcacatttgattgacagtccaccaacttacaatgctgactat
ggctacaaaagctgggaagccttctctaacctctcctattatactagagcccttcctcct
gtgcctgatgattgcccgactcccttgggtgtcaaaggtaaaaagcagcttcctgattca
aatgagattgtggaaaaattgcttctaagaagaaagttcatccctgatccccagggctca
aacatgatgtttgcattctttgcccagcacttcacgcatcagtttttcaagacagatcat
aagcgagggccagctttcaccaacgggctgggccatggggtggacttaaatcatatttac
ggtgaaactctggctagacagcgtaaactgcgccttttcaaggatggaaaaatgaaatat
cagataattgatggagagatgtatcctcccacagtcaaagatactcaggcagagatgatc
taccctcctcaagtccctgagcatctacggtttgctgtggggcaggaggtctttggtctg
gtgcctggtctgatgatgtatgccacaatctggctgcgggaacacaacagagtatgcgat
gtgcttaaacaggagcatcctgaatggggtgatgagcagttgttccagacaagcaggcta
atactgataggagagactattaagattgtgattgaagattatgtgcaacacttgagtggc
tatcacttcaaactgaaatttgacccagaactacttttcaacaaacaattccagtaccaa
aatcgtattgctgctgaatttaacaccctctatcactggcatccccttctgcctgacacc
tttcaaattcatgaccagaaatacaactatcaacagtttatctacaacaactctatattg
ctggaacatggaattacccagtttgttgaatcattcaccaggcaaattgctggcagggtt
gctggtggtaggaatgttccacccgcagtacagaaagtatcacaggcttccattgaccag
agcaggcagatgaaataccagtcttttaatgagtaccgcaaacgctttatgctgaagccc
tatgaatcatttgaagaacttacaggagaaaaggaaatgtctgcagagttggaagcactc
tatggtgacatcgatgctgtggagctgtatcctgcccttctggtagaaaagcctcggcca
gatgccatctttggtgaaaccatggtagaagttggagcaccattctccttgaaaggactt
atgggtaatgttatatgttctcctgcctactggaagccaagcacttttggtggagaagtg
ggttttcaaatcatcaacactgcctcaattcagtctctcatctgcaataacgtgaagggc
tgtccctttacttcattcagtgttccagatccagagctcattaaaacagtcaccatcaat
gcaagttcttcccgctccggactagatgatatcaatcccacagtactactaaaagaacgt
tcgactgaactgtag

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