Entry |
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Symbol |
PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
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Name |
(RefSeq) prostaglandin-endoperoxide synthase 2
|
KO |
|
Organism |
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Pathway |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04723 | Retrograde endocannabinoid signaling |
hsa04923 | Regulation of lipolysis in adipocytes |
hsa05022 | Pathways of neurodegeneration - multiple diseases |
hsa05163 | Human cytomegalovirus infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05204 | Chemical carcinogenesis - DNA adducts |
|
Network |
nt06124 Chemokine signaling (viruses) nt06150 Cytokine-cytokine receptor interaction (viruses) nt06167 Human cytomegalovirus (HCMV) nt06227 Nuclear receptor signaling nt06360 Cushing syndrome |
Element |
N00402 | HCMV US28 to GNAQ-PLCB/G-calcineurin signaling pathway |
|
Disease |
|
Drug target |
Phenbutazone sodium glycerate: | D05451 |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09103 Lipid metabolism
00590 Arachidonic acid metabolism
5743 (PTGS2)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
5743 (PTGS2)
04064 NF-kappa B signaling pathway
5743 (PTGS2)
04668 TNF signaling pathway
5743 (PTGS2)
09150 Organismal Systems
09151 Immune system
04625 C-type lectin receptor signaling pathway
5743 (PTGS2)
04657 IL-17 signaling pathway
5743 (PTGS2)
09152 Endocrine system
04923 Regulation of lipolysis in adipocytes
5743 (PTGS2)
04913 Ovarian steroidogenesis
5743 (PTGS2)
04921 Oxytocin signaling pathway
5743 (PTGS2)
09156 Nervous system
04726 Serotonergic synapse
5743 (PTGS2)
04723 Retrograde endocannabinoid signaling
5743 (PTGS2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5743 (PTGS2)
05206 MicroRNAs in cancer
5743 (PTGS2)
05204 Chemical carcinogenesis - DNA adducts
5743 (PTGS2)
09162 Cancer: specific types
05222 Small cell lung cancer
5743 (PTGS2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
5743 (PTGS2)
05167 Kaposi sarcoma-associated herpesvirus infection
5743 (PTGS2)
05165 Human papillomavirus infection
5743 (PTGS2)
09174 Infectious disease: parasitic
05140 Leishmaniasis
5743 (PTGS2)
09164 Neurodegenerative disease
05010 Alzheimer disease
5743 (PTGS2)
05022 Pathways of neurodegeneration - multiple diseases
5743 (PTGS2)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.99 Miscellaneous
1.14.99.1 prostaglandin-endoperoxide synthase
5743 (PTGS2)
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SSDB |
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Motif |
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Other DBs |
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Structure |
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LinkDB |
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Position |
1:complement(186671791..186680423)
|
AA seq |
604 aa
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL |
NT seq |
1815 nt +upstreamnt +downstreamnt
atgctcgcccgcgccctgctgctgtgcgcggtcctggcgctcagccatacagcaaatcct
tgctgttcccacccatgtcaaaaccgaggtgtatgtatgagtgtgggatttgaccagtat
aagtgcgattgtacccggacaggattctatggagaaaactgctcaacaccggaatttttg
acaagaataaaattatttctgaaacccactccaaacacagtgcactacatacttacccac
ttcaagggattttggaacgttgtgaataacattcccttccttcgaaatgcaattatgagt
tatgtgttgacatccagatcacatttgattgacagtccaccaacttacaatgctgactat
ggctacaaaagctgggaagccttctctaacctctcctattatactagagcccttcctcct
gtgcctgatgattgcccgactcccttgggtgtcaaaggtaaaaagcagcttcctgattca
aatgagattgtggaaaaattgcttctaagaagaaagttcatccctgatccccagggctca
aacatgatgtttgcattctttgcccagcacttcacgcatcagtttttcaagacagatcat
aagcgagggccagctttcaccaacgggctgggccatggggtggacttaaatcatatttac
ggtgaaactctggctagacagcgtaaactgcgccttttcaaggatggaaaaatgaaatat
cagataattgatggagagatgtatcctcccacagtcaaagatactcaggcagagatgatc
taccctcctcaagtccctgagcatctacggtttgctgtggggcaggaggtctttggtctg
gtgcctggtctgatgatgtatgccacaatctggctgcgggaacacaacagagtatgcgat
gtgcttaaacaggagcatcctgaatggggtgatgagcagttgttccagacaagcaggcta
atactgataggagagactattaagattgtgattgaagattatgtgcaacacttgagtggc
tatcacttcaaactgaaatttgacccagaactacttttcaacaaacaattccagtaccaa
aatcgtattgctgctgaatttaacaccctctatcactggcatccccttctgcctgacacc
tttcaaattcatgaccagaaatacaactatcaacagtttatctacaacaactctatattg
ctggaacatggaattacccagtttgttgaatcattcaccaggcaaattgctggcagggtt
gctggtggtaggaatgttccacccgcagtacagaaagtatcacaggcttccattgaccag
agcaggcagatgaaataccagtcttttaatgagtaccgcaaacgctttatgctgaagccc
tatgaatcatttgaagaacttacaggagaaaaggaaatgtctgcagagttggaagcactc
tatggtgacatcgatgctgtggagctgtatcctgcccttctggtagaaaagcctcggcca
gatgccatctttggtgaaaccatggtagaagttggagcaccattctccttgaaaggactt
atgggtaatgttatatgttctcctgcctactggaagccaagcacttttggtggagaagtg
ggttttcaaatcatcaacactgcctcaattcagtctctcatctgcaataacgtgaagggc
tgtccctttacttcattcagtgttccagatccagagctcattaaaacagtcaccatcaat
gcaagttcttcccgctccggactagatgatatcaatcccacagtactactaaaagaacgt
tcgactgaactgtag |