KEGG   Homo sapiens (human): 5777
Entry
5777              CDS       T01001                                 

Gene name
PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Definition
(RefSeq) protein tyrosine phosphatase non-receptor type 6
  KO
K05697  tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04520  Adherens junction
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa05130  Pathogenic Escherichia coli infection
hsa05140  Leishmaniasis
hsa05205  Proteoglycans in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06121  TLR signaling (viruses and bacteria)
  Element
N00926  Escherichia Tir to TLR2/4-MAPK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    5777 (PTPN6)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    5777 (PTPN6)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    5777 (PTPN6)
   04660 T cell receptor signaling pathway
    5777 (PTPN6)
   04662 B cell receptor signaling pathway
    5777 (PTPN6)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    5777 (PTPN6)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5777 (PTPN6)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    5777 (PTPN6)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    5777 (PTPN6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5777 (PTPN6)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     5777 (PTPN6)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    5777 (PTPN6)
SSDB
Motif
Pfam: Y_phosphatase SH2 DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 5777
NCBI-ProteinID: NP_002822
OMIM: 176883
HGNC: 9658
Ensembl: ENSG00000111679
Vega: OTTHUMG00000168518
Pharos: P29350(Tchem)
UniProt: P29350
LinkDB
Structure
PDB: 

Position
12p13.31
AA seq 595 aa
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
NT seq 1788 nt   +upstreamnt  +downstreamnt
atggtgaggtggtttcaccgagacctcagtgggctggatgcagagaccctgctcaagggc
cgaggtgtccacggtagcttcctggctcggcccagtcgcaagaaccagggtgacttctcg
ctctccgtcagggtgggggatcaggtgacccatattcggatccagaactcaggggatttc
tatgacctgtatggaggggagaagtttgcgactctgacagagctggtggagtactacact
cagcagcagggtgtcctgcaggaccgcgacggcaccatcatccacctcaagtacccgctg
aactgctccgatcccactagtgagaggtggtaccatggccacatgtctggcgggcaggca
gagacgctgctgcaggccaagggcgagccctggacgtttcttgtgcgtgagagcctcagc
cagcctggagacttcgtgctttctgtgctcagtgaccagcccaaggctggcccaggctcc
ccgctcagggtcacccacatcaaggtcatgtgcgagggtggacgctacacagtgggtggt
ttggagaccttcgacagcctcacggacctggtggagcatttcaagaagacggggattgag
gaggcctcaggcgcctttgtctacctgcggcagccgtactatgccacgagggtgaatgcg
gctgacattgagaaccgagtgttggaactgaacaagaagcaggagtccgaggatacagcc
aaggctggcttctgggaggagtttgagagtttgcagaagcaggaggtgaagaacttgcac
cagcgtctggaagggcagcggccagagaacaagggcaagaaccgctacaagaacattctc
ccctttgaccacagccgagtgatcctgcagggacgggacagtaacatccccgggtccgac
tacatcaatgccaactacatcaagaaccagctgctaggccctgatgagaacgctaagacc
tacatcgccagccagggttgtctggaggccacggtcaatgacttctggcagatggcgtgg
caggagaacagccgtgtcatcgtcatgaccacccgagaggtggagaaaggccggaacaaa
tgcgtcccatactggcccgaggtgggcatgcagcgtgcttatgggccctactctgtgacc
aactgcggggagcatgacacaaccgaatacaaactccgtaccttacaggtctccccgctg
gacaatggagacctgattcgggagatctggcattaccagtacctgagctggcccgaccat
ggggtccccagtgagcctgggggtgtcctcagcttcctggaccagatcaaccagcggcag
gaaagtctgcctcacgcagggcccatcatcgtgcactgcagcgccggcatcggccgcaca
ggcaccatcattgtcatcgacatgctcatggagaacatctccaccaagggcctggactgt
gacattgacatccagaagaccatccagatggtgcgggcgcagcgctcgggcatggtgcag
acggaggcgcagtacaagttcatctacgtggccatcgcccagttcattgaaaccactaag
aagaagctggaggtcctgcagtcgcagaagggccaggagtcggagtacgggaacatcacc
tatcccccagccatgaagaatgcccatgccaaggcctcccgcacctcgtccaaacacaag
gaggatgtgtatgagaacctgcacactaagaacaagagggaggagaaagtgaagaagcag
cggtcagcagacaaggagaagagcaagggttccctcaagaggaagtga

KEGG   Homo sapiens (human): 5781
Entry
5781              CDS       T01001                                 

Gene name
PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Definition
(RefSeq) protein tyrosine phosphatase non-receptor type 11
  KO
K07293  tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04360  Axon guidance
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04931  Insulin resistance
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05130  Pathogenic Escherichia coli infection
hsa05168  Herpes simplex virus 1 infection
hsa05205  Proteoglycans in cancer
hsa05211  Renal cell carcinoma
hsa05220  Chronic myeloid leukemia
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06121  TLR signaling (viruses and bacteria)
  Element
N00926  Escherichia Tir to TLR2/4-MAPK signaling pathway
Disease
H00523  Noonan syndrome and related disorders
H01018  Metachondromatosis
H01738  Noonan syndrome
H01984  Leopard syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    5781 (PTPN11)
   04630 JAK-STAT signaling pathway
    5781 (PTPN11)
   04072 Phospholipase D signaling pathway
    5781 (PTPN11)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    5781 (PTPN11)
   04650 Natural killer cell mediated cytotoxicity
    5781 (PTPN11)
   04670 Leukocyte transendothelial migration
    5781 (PTPN11)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    5781 (PTPN11)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    5781 (PTPN11)
  09158 Development and regeneration
   04360 Axon guidance
    5781 (PTPN11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    5781 (PTPN11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5781 (PTPN11)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    5781 (PTPN11)
   05211 Renal cell carcinoma
    5781 (PTPN11)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    5781 (PTPN11)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    5781 (PTPN11)
   05130 Pathogenic Escherichia coli infection
    5781 (PTPN11)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    5781 (PTPN11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5781 (PTPN11)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     5781 (PTPN11)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    5781 (PTPN11)
SSDB
Motif
Pfam: Y_phosphatase SH2 DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 5781
NCBI-ProteinID: NP_002825
OMIM: 176876
HGNC: 9644
Ensembl: ENSG00000179295
Vega: OTTHUMG00000134334
Pharos: Q06124(Tchem)
UniProt: Q06124
LinkDB
Structure
PDB: 

Position
12q24.13
AA seq 593 aa
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
NT seq 1782 nt   +upstreamnt  +downstreamnt
atgacatcgcggagatggtttcacccaaatatcactggtgtggaggcagaaaacctactg
ttgacaagaggagttgatggcagttttttggcaaggcctagtaaaagtaaccctggagac
ttcacactttccgttagaagaaatggagctgtcacccacatcaagattcagaacactggt
gattactatgacctgtatggaggggagaaatttgccactttggctgagttggtccagtat
tacatggaacatcacgggcaattaaaagagaagaatggagatgtcattgagcttaaatat
cctctgaactgtgcagatcctacctctgaaaggtggtttcatggacatctctctgggaaa
gaagcagagaaattattaactgaaaaaggaaaacatggtagttttcttgtacgagagagc
cagagccaccctggagattttgttctttctgtgcgcactggtgatgacaaaggggagagc
aatgacggcaagtctaaagtgacccatgttatgattcgctgtcaggaactgaaatacgac
gttggtggaggagaacggtttgattctttgacagatcttgtggaacattataagaagaat
cctatggtggaaacattgggtacagtactacaactcaagcagccccttaacacgactcgt
ataaatgctgctgaaatagaaagcagagttcgagaactaagcaaattagctgagaccaca
gataaagtcaaacaaggcttttgggaagaatttgagacactacaacaacaggagtgcaaa
cttctctacagccgaaaagagggtcaaaggcaagaaaacaaaaacaaaaatagatataaa
aacatcctgccctttgatcataccagggttgtcctacacgatggtgatcccaatgagcct
gtttcagattacatcaatgcaaatatcatcatgcctgaatttgaaaccaagtgcaacaat
tcaaagcccaaaaagagttacattgccacacaaggctgcctgcaaaacacggtgaatgac
ttttggcggatggtgttccaagaaaactcccgagtgattgtcatgacaacgaaagaagtg
gagagaggaaagagtaaatgtgtcaaatactggcctgatgagtatgctctaaaagaatat
ggcgtcatgcgtgttaggaacgtcaaagaaagcgccgctcatgactatacgctaagagaa
cttaaactttcaaaggttggacaagggaatacggagagaacggtctggcaataccacttt
cggacctggccggaccacggcgtgcccagcgaccctgggggcgtgctggacttcctggag
gaggtgcaccataagcaggagagcatcatggatgcagggccggtcgtggtgcactgcagt
gctggaattggccggacagggacgttcattgtgattgatattcttattgacatcatcaga
gagaaaggtgttgactgcgatattgacgttcccaaaaccatccagatggtgcggtctcag
aggtcagggatggtccagacagaagcacagtaccgatttatctatatggcggtccagcat
tatattgaaacactacagcgcaggattgaagaagagcagaaaagcaagaggaaagggcac
gaatatacaaatattaagtattctctagcggaccagacgagtggagatcagagccctctc
ccgccttgtactccaacgccaccctgtgcagaaatgagagaagacagtgctagagtctat
gaaaacgtgggcctgatgcaacagcagaaaagtttcagatga

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