KEGG   Homo sapiens (human): 6240
Entry
6240              CDS       T01001                                 
Symbol
RRM1, PEOB6, R1, RIR1, RR1
Name
(RefSeq) ribonucleotide reductase catalytic subunit M1
  KO
K10807  ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa00480  Glutathione metabolism
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
Module
hsa_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP
hsa_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Disease
H01395  Autosomal recessive progressive external ophthalmoplegia
Drug target
Caracemide: D03378
Cladribine: D01370<JP/US>
Clofarabine: D03546<JP/US>
Fludarabine (DG00685): D01907<JP/US> D07966
Fosgemcitabine palabenamide: D12387
Gemcitabine (DG00688): D01155<JP/US> D02368 D10222
Tezacitabine: D06100
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    6240 (RRM1)
   00240 Pyrimidine metabolism
    6240 (RRM1)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    6240 (RRM1)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    6240 (RRM1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    6240 (RRM1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1  ribonucleoside-diphosphate reductase
     6240 (RRM1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Other factors with a suspected DNA repair function
   Modulation of nucleotide pools
    6240 (RRM1)
SSDB
Motif
Pfam: Ribonuc_red_lgC Ribonuc_red_lgN ATP-cone
Other DBs
NCBI-GeneID: 6240
NCBI-ProteinID: NP_001024
OMIM: 180410
HGNC: 10451
Ensembl: ENSG00000167325
UniProt: P23921
Structure
LinkDB
Position
11:4094685..4138932
AA seq 792 aa
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
NT seq 2379 nt   +upstreamnt  +downstreamnt
atgcatgtgatcaagcgagatggccgccaagaacgagtcatgtttgacaaaattacatct
cgaatccagaagctttgttatggactcaatatggattttgttgatcctgctcagatcacc
atgaaagtaatccaaggcttgtacagtggggtcaccacagtggaactagatactttggct
gctgaaacagctgcaaccttgactactaagcaccctgactatgctatcctggcagccagg
atcgctgtctctaacttgcacaaagaaacaaagaaagtgttcagtgatgtgatggaagac
ctctataactacataaatccacataatggcaaacactctcccatggtggccaagtcaaca
ttggatattgttctggccaataaagatcgcctgaattctgctattatctatgaccgagat
ttctcttacaattacttcggctttaagacgctagagcggtcttatttgttgaagatcaat
ggaaaagtggctgaaagaccacaacatatgttgatgagagtatctgttgggatccacaaa
gaagacattgatgcagcaattgaaacatataatcttctttctgagaggtggtttactcat
gcttcgcccactctcttcaatgctggtaccaaccgcccacaactttctagctgttttctt
ctgagtatgaaagatgacagcattgaaggcatttatgacactctaaagcaatgtgcattg
atttctaagtctgctggaggaattggtgttgctgtgagttgtattcgggctactggcagc
tacattgctgggactaatggcaattccaatggccttgtaccgatgctgagagtatataac
aacacagctcgatatgtggatcaaggtgggaacaagcgtcctggggcatttgctatttac
ctggagccttggcatttagacatctttgaattccttgatttaaagaagaacacaggaaag
gaagagcagcgtgccagagatcttttctttgctctttggattccggatctcttcatgaaa
cgagtggagactaatcaggactggtctttgatgtgtccaaatgagtgtcctggtctggat
gaggtttggggagaggaatttgagaaactatatgcaagttatgagaaacaaggtcgtgtc
cgcaaagttgtaaaagctcagcagctttggtatgccatcattgagtctcagacggaaaca
ggcaccccgtatatgctctacaaagattcctgtaatcgaaagagcaaccagcagaacctg
ggaaccatcaaatgcagcaacctgtgcacagaaatagtggagtacaccagcaaagatgag
gttgctgtttgtaatttggcttccctggccctgaatatgtatgtcacatcagaacacaca
tacgactttaagaagttggctgaagtcactaaagtcgttgtccgaaacttgaataaaatt
attgatataaactactatcctgtaccagaggcatgcctatcaaataaacgccatcgcccc
attggaattggggtacaaggtctggcagatgcttttatcctgatgagatacccttttgag
agtgcagaagcccagttactgaataagcagatctttgaaactatttattatggtgctctg
gaagccagctgtgaccttgccaaggagcagggcccatacgaaacctatgagggctctcca
gttagcaaaggaattcttcagtatgatatgtggaatgttactcctacagacctatgggac
tggaaggttctcaaggagaagattgcaaagtatggtataagaaacagtttacttattgcc
ccgatgcctacagcttccactgctcagatcctggggaataatgagtccattgaaccttac
accagcaacatctatactcgcagagtcttgtcaggagaatttcagattgtaaatcctcac
ttattgaaagatcttaccgagcggggcctatggcatgaagagatgaaaaaccagattatt
gcatgcaatggctctattcagagcataccagaaattcctgatgacctgaagcaactttat
aaaactgtgtgggaaatctctcagaaaactgttctcaagatggcagctgagagaggtgct
ttcattgatcaaagccaatctttgaacatccacattgctgagcctaactatggcaaactc
actagtatgcacttctacggctggaagcagggtttgaagactgggatgtattatttaagg
acaagaccagcggctaatccaatccagttcactctaaataaggagaagctaaaagataaa
gaaaaggtatcaaaagaggaagaagagaaggagaggaacacagcagccatggtgtgctct
ttggagaatagagatgaatgtctgatgtgtggatcctga

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