Homo sapiens (human): 6256
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Entry
6256 CDS
T01001
Symbol
RXRA, NR2B1, RXR-alpha, RXRalpha
Name
(RefSeq) retinoid X receptor alpha
KO
K08524
retinoid X receptor alpha
Organism
hsa
Homo sapiens (human)
Pathway
hsa03320
PPAR signaling pathway
hsa04148
Efferocytosis
hsa04151
PI3K-Akt signaling pathway
hsa04659
Th17 cell differentiation
hsa04919
Thyroid hormone signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa04932
Non-alcoholic fatty liver disease
hsa04976
Bile secretion
hsa05160
Hepatitis C
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05216
Thyroid cancer
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05226
Gastric cancer
hsa05417
Lipid and atherosclerosis
Network
nt06163
Hepatitis C virus (HCV)
nt06240
Transcription (cancer)
nt06263
Hepatocellular carcinoma
nt06274
Thyroid cancer
nt06322
TRH-TSH-TH signaling
nt06535
Efferocytosis
Element
N00126
PAX8-PPARG fusion to PPARG-mediated transcription
N00529
HCV core to RXRA/PPARA-mediated transcription
N00530
HCV core to RXRA/LXRA-mediated transcription
N00798
Thyroid hormone signaling pathway
N01751
Macrophage EPO signaling
Drug target
Acitretin:
D02754
<US>
Alitretinoin:
D02815
<US>
Bexarotene:
D03106
<JP/US>
Etretinate:
D00316
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
6256 (RXRA)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
6256 (RXRA)
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
6256 (RXRA)
09152 Endocrine system
04919 Thyroid hormone signaling pathway
6256 (RXRA)
04928 Parathyroid hormone synthesis, secretion and action
6256 (RXRA)
09154 Digestive system
04976 Bile secretion
6256 (RXRA)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
6256 (RXRA)
05202 Transcriptional misregulation in cancer
6256 (RXRA)
05207 Chemical carcinogenesis - receptor activation
6256 (RXRA)
09162 Cancer: specific types
05226 Gastric cancer
6256 (RXRA)
05216 Thyroid cancer
6256 (RXRA)
05222 Small cell lung cancer
6256 (RXRA)
05223 Non-small cell lung cancer
6256 (RXRA)
09172 Infectious disease: viral
05160 Hepatitis C
6256 (RXRA)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
6256 (RXRA)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
6256 (RXRA)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
6256 (RXRA)
09183 Protein families: signaling and cellular processes
03310 Nuclear receptors [BR:
hsa03310
]
6256 (RXRA)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 hepatocyte nuclear factor 4-like
6256 (RXRA)
Nuclear receptors [BR:
hsa03310
]
2. Hepatocyte nuclear factor 4 like
2B. Retinoid X receptor (RXR)
6256 (RXRA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Hormone_recep
Nuc_recep-AF1
zf-C4
tRNA_bind_3
Motif
Other DBs
NCBI-GeneID:
6256
NCBI-ProteinID:
NP_002948
OMIM:
180245
HGNC:
10477
Ensembl:
ENSG00000186350
UniProt:
P19793
F1D8Q5
Q6P3U7
Structure
PDB
PDBj
LinkDB
All DBs
Position
9:134326455..134440585
Genome browser
AA seq
462 aa
AA seq
DB search
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
NT seq
1389 nt
NT seq
+upstream
nt +downstream
nt
atggacaccaaacatttcctgccgctcgatttctccacccaggtgaactcctccctcacc
tccccgacggggcgaggctccatggctgccccctcgctgcacccgtccctggggcctggc
atcggctccccgggacagctgcattctcccatcagcaccctgagctcccccatcaacggc
atgggcccgcctttctcggtcatcagctcccccatgggcccccactccatgtcggtgccc
accacacccaccctgggcttcagcactggcagcccccagctcagctcacctatgaacccc
gtcagcagcagcgaggacatcaagccccccctgggcctcaatggcgtcctcaaggtcccc
gcccacccctcaggaaacatggcttccttcaccaagcacatctgcgccatctgcggggac
cgctcctcaggcaagcactatggagtgtacagctgcgaggggtgcaagggcttcttcaag
cggacggtgcgcaaggacctgacctacacctgccgcgacaacaaggactgcctgattgac
aagcggcagcggaaccggtgccagtactgccgctaccagaagtgcctggccatgggcatg
aagcgggaagccgtgcaggaggagcggcagcgtggcaaggaccggaacgagaatgaggtg
gagtcgaccagcagcgccaacgaggacatgccggtggagaggatcctggaggctgagctg
gccgtggagcccaagaccgagacctacgtggaggcaaacatggggctgaaccccagctcg
ccgaacgaccctgtcaccaacatttgccaagcagccgacaaacagcttttcaccctggtg
gagtgggccaagcggatcccacacttctcagagctgcccctggacgaccaggtcatcctg
ctgcgggcaggctggaatgagctgctcatcgcctccttctcccaccgctccatcgccgtg
aaggacgggatcctcctggccaccgggctgcacgtccaccggaacagcgcccacagcgca
ggggtgggcgccatctttgacagggtgctgacggagcttgtgtccaagatgcgggacatg
cagatggacaagacggagctgggctgcctgcgcgccatcgtcctctttaaccctgactcc
aaggggctctcgaacccggccgaggtggaggcgctgagggagaaggtctatgcgtccttg
gaggcctactgcaagcacaagtacccagagcagccgggaaggttcgctaagctcttgctc
cgcctgccggctctgcgctccatcgggctcaaatgcctggaacatctcttcttcttcaag
ctcatcggggacacacccattgacaccttccttatggagatgctggaggcgccgcaccaa
atgacttag
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