KEGG T01001: 6850

nt06114  PI3K signaling (viruses)
nt06120  Calcium signaling (viruses and bacteria)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06165  Epstein-Barr virus (EBV)
nt06220  Calcium signaling

Element

N00266

EBV LMP2A to PI3K signaling pathway

N00487

BCR-PLCG-Calcineurin signaling pathway

N00488

EBV LMP2A to BCR signaling pathway

Drug target

Entospletinib:

D11209

Fostamatinib (DG01419):

D09347 D09348<US>

Gusacitinib (DG03080):

D11676 D11677

Mivavotinib (DG03106):

D11789 D11790

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    6850 (SYK)
   04072 Phospholipase D signaling pathway
    6850 (SYK)
   04151 PI3K-Akt signaling pathway
    6850 (SYK)
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    6850 (SYK)
   04613 Neutrophil extracellular trap formation
    6850 (SYK)
   04625 C-type lectin receptor signaling pathway
    6850 (SYK)
   04650 Natural killer cell mediated cytotoxicity
    6850 (SYK)
   04662 B cell receptor signaling pathway
    6850 (SYK)
   04664 Fc epsilon RI signaling pathway
    6850 (SYK)
   04666 Fc gamma R-mediated phagocytosis
    6850 (SYK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    6850 (SYK)
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    6850 (SYK)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    6850 (SYK)
   05168 Herpes simplex virus 1 infection
    6850 (SYK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    6850 (SYK)
   05169 Epstein-Barr virus infection
    6850 (SYK)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    6850 (SYK)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6850 (SYK)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     6850 (SYK)
Protein kinases [BR:hsa01001]
Non-receptor tyrosine kinases
  SYK family
   6850 (SYK)

SSDB

Motif

Pfam:

PK_Tyr_Ser-Thr Pkinase SH2 Kdo

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P43405(Tchem)

UniProt:

P43405 A0A024R244

LinkDB

Structure

PDB:

4YJR 4YJQ 4FYO 5LMA 5TIU 4YJT 1XBB 4RX8 4YJO 4PX6 6HM7 4YJV 4YJU 5CXZ 4I0T 4RX9 4FZ7 5CY3 4XG7 5TT7 4FL1 5Y5T 4RX7 4YJP 4RSS 4FZ6 5CXH 4FL3 5TR6 5LMB 5C26 3SRV 4I0S 4DFL 4PV0 1XBA 1XBC 4PUZ 3VF8 6HM6 4I0R 3TUC 3FQS 5Y5U 5C27 4FL2 4XG2 4YJS 3TUB 3FQH 4XG3 4XG4 3VF9 4FYN 3TUD 4GFG 4F4P 4XG6 4XG8 4DFN 4WNM 3FQE 3EMG 5GHV 4XG9 5T68 1A81 1CSY 1CSZ

Position

9q22.2

AA seq 635 aa
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN

NT seq 1908 nt +upstreamnt +downstreamnt
atggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatc
acccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttg
ctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaag
gcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcagg
acccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtc
tgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggcccttt
gaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggt
caggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctacc
acagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaa
attgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaac
ggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaa
gacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagcta
gtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaa
aaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccat
cctgcgacttggtcagcgggtggaataatctcaagaatcaaatcatactccttcccaaag
cctggccacagaaagtcctcccctgcccaagggaaccggcaagagagtactgtgtcattc
aatccgtatgagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagcc
ctacccatggacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggccc
aaggaggtttacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggt
aattttggaactgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggct
gtgaaaatactgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaa
gcaaatgtcatgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgag
gccgagtcctggatgctggttatggagatggcagaacttggtcccctcaataagtatttg
cagcagaacagacatgtcaaggataagaacatcatagaactggttcatcaggtttccatg
ggcatgaagtacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtg
ttgctagttacccaacattacgccaagatcagtgatttcggactttccaaagcactgcgt
gctgatgaaaactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgct
ccggaatgcatcaactactacaagttctccagcaaaagcgatgtctggagctttggagtg
ttgatgtgggaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaa
gtcaccgctatgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagag
atgtacgatctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgca
gcagtggaactgcggctgcgcaattactactatgacgtggtgaactaa

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