Homo sapiens (human): 6850
Entry
6850 CDS
T01001
Gene name
SYK, p72-Syk
Definition
(RefSeq) spleen associated tyrosine kinase
KO
K05855
spleen tyrosine kinase [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04064
NF-kappa B signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04380
Osteoclast differentiation
hsa04611
Platelet activation
hsa04625
C-type lectin receptor signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa05152
Tuberculosis
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05203
Viral carcinogenesis
Network
nt06114
PI3K signaling (virus)
nt06120
Calcium signaling (virus)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06165
Epstein-Barr virus (EBV)
nt06220
Calcium signaling
Element
N00266
EBV LMP2A to PI3K signaling pathway
N00487
BCR-PLCG-Calcineurin signaling pathway
N00488
EBV LMP2A to BCR signaling pathway
Drug target
Entospletinib:
D11209
Fostamatinib (
DG01419
):
D09347
D09348
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
6850 (SYK)
04072 Phospholipase D signaling pathway
6850 (SYK)
04151 PI3K-Akt signaling pathway
6850 (SYK)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
6850 (SYK)
04625 C-type lectin receptor signaling pathway
6850 (SYK)
04650 Natural killer cell mediated cytotoxicity
6850 (SYK)
04662 B cell receptor signaling pathway
6850 (SYK)
04664 Fc epsilon RI signaling pathway
6850 (SYK)
04666 Fc gamma R-mediated phagocytosis
6850 (SYK)
09158 Development
04380 Osteoclast differentiation
6850 (SYK)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
6850 (SYK)
09171 Infectious disease: bacterial
05152 Tuberculosis
6850 (SYK)
09172 Infectious disease: viral
05168 Herpes simplex virus 1 infection
6850 (SYK)
05167 Kaposi sarcoma-associated herpesvirus infection
6850 (SYK)
05169 Epstein-Barr virus infection
6850 (SYK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
6850 (SYK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
6850 (SYK)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SYK family
6850 (SYK)
SSDB
Motif
Pfam:
Pkinase_Tyr
Pkinase
SH2
Kdo
Haspin_kinase
Other DBs
NCBI-GeneID:
6850
NCBI-ProteinID:
NP_001167638
OMIM:
600085
HGNC:
11491
Ensembl:
ENSG00000165025
Vega:
OTTHUMG00000020200
Pharos:
P43405
(Tchem)
UniProt:
P43405
A0A024R244
LinkDB
Structure
PDB:
4YJR
4YJQ
4FYO
5LMA
5TIU
4YJT
1XBB
4RX8
4YJO
4PX6
6HM7
4YJV
4YJU
5CXZ
4I0T
4RX9
4FZ7
5CY3
4XG7
5TT7
4FL1
5Y5T
4RX7
4YJP
4RSS
4FZ6
5CXH
4FL3
5TR6
5LMB
5C26
3SRV
4I0S
4DFL
4PV0
1XBA
1XBC
4PUZ
3VF8
6HM6
4I0R
3TUC
3FQS
5Y5U
5C27
4FL2
4XG2
4YJS
3TUB
3FQH
4XG3
4XG4
3VF9
4FYN
3TUD
4GFG
4F4P
4XG6
4XG8
4DFN
4WNM
3FQE
3EMG
5GHV
4XG9
5T68
1A81
1CSY
1CSZ
Position
9q22.2
AA seq
635 aa
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
NT seq
1908 nt
+upstream
nt +downstream
nt
atggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatc
acccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttg
ctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaag
gcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcagg
acccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtc
tgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggcccttt
gaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggt
caggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctacc
acagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaa
attgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaac
ggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaa
gacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagcta
gtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaa
aaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccat
cctgcgacttggtcagcgggtggaataatctcaagaatcaaatcatactccttcccaaag
cctggccacagaaagtcctcccctgcccaagggaaccggcaagagagtactgtgtcattc
aatccgtatgagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagcc
ctacccatggacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggccc
aaggaggtttacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggt
aattttggaactgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggct
gtgaaaatactgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaa
gcaaatgtcatgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgag
gccgagtcctggatgctggttatggagatggcagaacttggtcccctcaataagtatttg
cagcagaacagacatgtcaaggataagaacatcatagaactggttcatcaggtttccatg
ggcatgaagtacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtg
ttgctagttacccaacattacgccaagatcagtgatttcggactttccaaagcactgcgt
gctgatgaaaactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgct
ccggaatgcatcaactactacaagttctccagcaaaagcgatgtctggagctttggagtg
ttgatgtgggaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaa
gtcaccgctatgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagag
atgtacgatctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgca
gcagtggaactgcggctgcgcaattactactatgacgtggtgaactaa
DBGET
integrated database retrieval system
