Entry |
|
Gene name |
SYK, p72-Syk
|
Definition |
(RefSeq) spleen associated tyrosine kinase
|
KO |
|
Organism |
|
Pathway |
hsa04072 | Phospholipase D signaling pathway |
hsa04613 | Neutrophil extracellular trap formation |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04650 | Natural killer cell mediated cytotoxicity |
hsa04662 | B cell receptor signaling pathway |
hsa04664 | Fc epsilon RI signaling pathway |
hsa04666 | Fc gamma R-mediated phagocytosis |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05168 | Herpes simplex virus 1 infection |
|
Network |
nt06114 PI3K signaling (viruses) nt06120 Calcium signaling (viruses and bacteria) nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06165 Epstein-Barr virus (EBV) nt06220 Calcium signaling |
Element |
N00266 | EBV LMP2A to PI3K signaling pathway |
N00487 | BCR-PLCG-Calcineurin signaling pathway |
N00488 | EBV LMP2A to BCR signaling pathway |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
6850 (SYK)
04072 Phospholipase D signaling pathway
6850 (SYK)
04151 PI3K-Akt signaling pathway
6850 (SYK)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
6850 (SYK)
04613 Neutrophil extracellular trap formation
6850 (SYK)
04625 C-type lectin receptor signaling pathway
6850 (SYK)
04650 Natural killer cell mediated cytotoxicity
6850 (SYK)
04662 B cell receptor signaling pathway
6850 (SYK)
04664 Fc epsilon RI signaling pathway
6850 (SYK)
04666 Fc gamma R-mediated phagocytosis
6850 (SYK)
09158 Development and regeneration
04380 Osteoclast differentiation
6850 (SYK)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
6850 (SYK)
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
6850 (SYK)
05168 Herpes simplex virus 1 infection
6850 (SYK)
05167 Kaposi sarcoma-associated herpesvirus infection
6850 (SYK)
05169 Epstein-Barr virus infection
6850 (SYK)
09171 Infectious disease: bacterial
05152 Tuberculosis
6850 (SYK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
6850 (SYK)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
6850 (SYK)
Protein kinases [BR:hsa01001]
Non-receptor tyrosine kinases
SYK family
6850 (SYK)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Structure |
PDB: |
Position |
9q22.2
|
AA seq |
635 aa
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN |
NT seq |
1908 nt +upstreamnt +downstreamnt
atggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatc
acccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttg
ctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaag
gcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcagg
acccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtc
tgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggcccttt
gaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggt
caggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctacc
acagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaa
attgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaac
ggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaa
gacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagcta
gtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaa
aaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccat
cctgcgacttggtcagcgggtggaataatctcaagaatcaaatcatactccttcccaaag
cctggccacagaaagtcctcccctgcccaagggaaccggcaagagagtactgtgtcattc
aatccgtatgagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagcc
ctacccatggacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggccc
aaggaggtttacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggt
aattttggaactgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggct
gtgaaaatactgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaa
gcaaatgtcatgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgag
gccgagtcctggatgctggttatggagatggcagaacttggtcccctcaataagtatttg
cagcagaacagacatgtcaaggataagaacatcatagaactggttcatcaggtttccatg
ggcatgaagtacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtg
ttgctagttacccaacattacgccaagatcagtgatttcggactttccaaagcactgcgt
gctgatgaaaactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgct
ccggaatgcatcaactactacaagttctccagcaaaagcgatgtctggagctttggagtg
ttgatgtgggaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaa
gtcaccgctatgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagag
atgtacgatctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgca
gcagtggaactgcggctgcgcaattactactatgacgtggtgaactaa |