KEGG   Homo sapiens (human): 7042
Entry
7042              CDS       T01001                                 
Symbol
TGFB2, G-TSF, LDS4, TGF-beta2
Name
(RefSeq) transforming growth factor beta 2
  KO
K13376  transforming growth factor beta-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04218  Cellular senescence
hsa04350  TGF-beta signaling pathway
hsa04380  Osteoclast differentiation
hsa04390  Hippo signaling pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05144  Malaria
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05166  Human T-cell leukemia virus 1 infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05220  Chronic myeloid leukemia
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05410  Hypertrophic cardiomyopathy
hsa05414  Dilated cardiomyopathy
hsa05415  Diabetic cardiomyopathy
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06218  TGFB signaling (cancer)
nt06225  HIF-1 signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06276  Chronic myeloid leukemia
nt06507  TGFB signaling
  Element
N00063  TGF-beta signaling pathway
N00079  HIF-1 signaling pathway
N00080  Loss of VHL to HIF-1 signaling pathway
N00081  Mutation-inactivated VHL to HIF-1 signaling pathway
N00531  HBV HBx to TGF-beta signaling pathway
N01460  Plasmin mediated activation of latent TGF-beta
Disease
H00083  Allograft rejection
H00084  Graft-versus-host disease
H00800  Loeys-Dietz syndrome
Drug target
Belagenpumatucel-L: D06563
Fresolimumab: D09620
Trabedersen: D10203
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7042 (TGFB2)
   04350 TGF-beta signaling pathway
    7042 (TGFB2)
   04390 Hippo signaling pathway
    7042 (TGFB2)
   04068 FoxO signaling pathway
    7042 (TGFB2)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    7042 (TGFB2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    7042 (TGFB2)
   04218 Cellular senescence
    7042 (TGFB2)
 09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    7042 (TGFB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7042 (TGFB2)
   05206 MicroRNAs in cancer
    7042 (TGFB2)
   05205 Proteoglycans in cancer
    7042 (TGFB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    7042 (TGFB2)
   05212 Pancreatic cancer
    7042 (TGFB2)
   05225 Hepatocellular carcinoma
    7042 (TGFB2)
   05226 Gastric cancer
    7042 (TGFB2)
   05220 Chronic myeloid leukemia
    7042 (TGFB2)
   05211 Renal cell carcinoma
    7042 (TGFB2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    7042 (TGFB2)
   05161 Hepatitis B
    7042 (TGFB2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    7042 (TGFB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    7042 (TGFB2)
   05144 Malaria
    7042 (TGFB2)
   05145 Toxoplasmosis
    7042 (TGFB2)
   05140 Leishmaniasis
    7042 (TGFB2)
   05142 Chagas disease
    7042 (TGFB2)
  09163 Immune disease
   05323 Rheumatoid arthritis
    7042 (TGFB2)
   05321 Inflammatory bowel disease
    7042 (TGFB2)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    7042 (TGFB2)
   05414 Dilated cardiomyopathy
    7042 (TGFB2)
   05415 Diabetic cardiomyopathy
    7042 (TGFB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    7042 (TGFB2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    7042 (TGFB2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7042 (TGFB2)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Transforming growth factors (RSTK binding)
   7042 (TGFB2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   7042 (TGFB2)
SSDB
Motif
Pfam: TGFb_propeptide TGF_beta SPEG_u2
Other DBs
NCBI-GeneID: 7042
NCBI-ProteinID: NP_003229
OMIM: 190220
HGNC: 11768
Ensembl: ENSG00000092969
UniProt: P61812 Q59EG9
Structure
LinkDB
Position
1:218345336..218444619
AA seq 414 aa
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPP
TFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSP
TQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIP
NKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRK
KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQH
SRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
NT seq 1245 nt   +upstreamnt  +downstreamnt
atgcactactgtgtgctgagcgcttttctgatcctgcatctggtcacggtcgcgctcagc
ctgtctacctgcagcacactcgatatggaccagttcatgcgcaagaggatcgaggcgatc
cgcgggcagatcctgagcaagctgaagctcaccagtcccccagaagactatcctgagccc
gaggaagtccccccggaggtgatttccatctacaacagcaccagggacttgctccaggag
aaggcgagccggagggcggccgcctgcgagcgcgagaggagcgacgaagagtactacgcc
aaggaggtttacaaaatagacatgccgcccttcttcccctccgaaaatgccatcccgccc
actttctacagaccctacttcagaattgttcgatttgacgtctcagcaatggagaagaat
gcttccaatttggtgaaagcagagttcagagtctttcgtttgcagaacccaaaagccaga
gtgcctgaacaacggattgagctatatcagattctcaagtccaaagatttaacatctcca
acccagcgctacatcgacagcaaagttgtgaaaacaagagcagaaggcgaatggctctcc
ttcgatgtaactgatgctgttcatgaatggcttcaccataaagacaggaacctgggattt
aaaataagcttacactgtccctgctgcacttttgtaccatctaataattacatcatccca
aataaaagtgaagaactagaagcaagatttgcaggtattgatggcacctccacatatacc
agtggtgatcagaaaactataaagtccactaggaaaaaaaacagtgggaagaccccacat
ctcctgctaatgttattgccctcctacagacttgagtcacaacagaccaaccggcggaag
aagcgtgctttggatgcggcctattgctttagaaatgtgcaggataattgctgcctacgt
ccactttacattgatttcaagagggatctagggtggaaatggatacacgaacccaaaggg
tacaatgccaacttctgtgctggagcatgcccgtatttatggagttcagacactcagcac
agcagggtcctgagcttatataataccataaatccagaagcatctgcttctccttgctgc
gtgtcccaagatttagaacctctaaccattctctactacattggcaaaacacccaagatt
gaacagctttctaatatgattgtaaagtcttgcaaatgcagctaa

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