Homo sapiens (human): 7043
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Entry
7043 CDS
T01001
Symbol
TGFB3, ARVD, ARVD1, LDS5, RNHF, TGF-beta3
Name
(RefSeq) transforming growth factor beta 3
KO
K13377
transforming growth factor beta-3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04218
Cellular senescence
hsa04350
TGF-beta signaling pathway
hsa04390
Hippo signaling pathway
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05144
Malaria
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05166
Human T-cell leukemia virus 1 infection
hsa05200
Pathways in cancer
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05220
Chronic myeloid leukemia
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05321
Inflammatory bowel disease
hsa05323
Rheumatoid arthritis
hsa05410
Hypertrophic cardiomyopathy
hsa05414
Dilated cardiomyopathy
hsa05415
Diabetic cardiomyopathy
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06218
TGFB signaling (cancer)
nt06225
HIF-1 signaling (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
nt06276
Chronic myeloid leukemia
nt06507
TGFB signaling
Element
N00063
TGF-beta signaling pathway
N00079
HIF-1 signaling pathway
N00080
Loss of VHL to HIF-1 signaling pathway
N00081
Mutation-inactivated VHL to HIF-1 signaling pathway
N00531
HBV HBx to TGF-beta signaling pathway
N01460
Plasmin mediated activation of latent TGF-beta
Disease
H00083
Allograft rejection
H00084
Graft-versus-host disease
H00293
Arrhythmogenic right ventricular cardiomyopathy
H00431
Ossification of the posterior longitudinal ligament of spine
H00800
Loeys-Dietz syndrome
H01385
Rienhoff syndrome
Drug target
Fresolimumab:
D09620
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
7043 (TGFB3)
04350 TGF-beta signaling pathway
7043 (TGFB3)
04390 Hippo signaling pathway
7043 (TGFB3)
04068 FoxO signaling pathway
7043 (TGFB3)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
7043 (TGFB3)
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
7043 (TGFB3)
04218 Cellular senescence
7043 (TGFB3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
7043 (TGFB3)
09162 Cancer: specific types
05210 Colorectal cancer
7043 (TGFB3)
05212 Pancreatic cancer
7043 (TGFB3)
05225 Hepatocellular carcinoma
7043 (TGFB3)
05226 Gastric cancer
7043 (TGFB3)
05220 Chronic myeloid leukemia
7043 (TGFB3)
05211 Renal cell carcinoma
7043 (TGFB3)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
7043 (TGFB3)
05161 Hepatitis B
7043 (TGFB3)
09171 Infectious disease: bacterial
05152 Tuberculosis
7043 (TGFB3)
09174 Infectious disease: parasitic
05146 Amoebiasis
7043 (TGFB3)
05144 Malaria
7043 (TGFB3)
05145 Toxoplasmosis
7043 (TGFB3)
05140 Leishmaniasis
7043 (TGFB3)
05142 Chagas disease
7043 (TGFB3)
09163 Immune disease
05323 Rheumatoid arthritis
7043 (TGFB3)
05321 Inflammatory bowel disease
7043 (TGFB3)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
7043 (TGFB3)
05414 Dilated cardiomyopathy
7043 (TGFB3)
05415 Diabetic cardiomyopathy
7043 (TGFB3)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
7043 (TGFB3)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
7043 (TGFB3)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Transforming growth factors (RSTK binding)
7043 (TGFB3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
TGFb_propeptide
TGF_beta
Motif
Other DBs
NCBI-GeneID:
7043
NCBI-ProteinID:
NP_001316868
OMIM:
190230
HGNC:
11769
Ensembl:
ENSG00000119699
UniProt:
P10600
A5YM40
Structure
PDB
LinkDB
All DBs
Position
14:complement(75958097..75983011)
Genome browser
AA seq
412 aa
AA seq
DB search
MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT
VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL
AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI
AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE
NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR
ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST
VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
NT seq
1239 nt
NT seq
+upstream
nt +downstream
nt
atgaagatgcacttgcaaagggctctggtggtcctggccctgctgaactttgccacggtc
agcctctctctgtccacttgcaccaccttggacttcggccacatcaagaagaagagggtg
gaagccattaggggacagatcttgagcaagctcaggctcaccagcccccctgagccaacg
gtgatgacccacgtcccctatcaggtcctggccctttacaacagcacccgggagctgctg
gaggagatgcatggggagagggaggaaggctgcacccaggaaaacaccgagtcggaatac
tatgccaaagaaatccataaattcgacatgatccaggggctggcggagcacaacgaactg
gctgtctgccctaaaggaattacctccaaggttttccgcttcaatgtgtcctcagtggag
aaaaatagaaccaacctattccgagcagaattccgggtcttgcgggtgcccaaccccagc
tctaagcggaatgagcagaggatcgagctcttccagatccttcggccagatgagcacatt
gccaaacagcgctatatcggtggcaagaatctgcccacacggggcactgccgagtggctg
tcctttgatgtcactgacactgtgcgtgagtggctgttgagaagagagtccaacttaggt
ctagaaatcagcattcactgtccatgtcacacctttcagcccaatggagatatcctggaa
aacattcacgaggtgatggaaatcaaattcaaaggcgtggacaatgaggatgaccatggc
cgtggagatctggggcgcctcaagaagcagaaggatcaccacaaccctcatctaatcctc
atgatgattcccccacaccggctcgacaacccgggccaggggggtcagaggaagaagcgg
gctttggacaccaattactgcttccgcaacttggaggagaactgctgtgtgcgccccctc
tacattgacttccgacaggatctgggctggaagtgggtccatgaacctaagggctactat
gccaacttctgctcaggcccttgcccatacctccgcagtgcagacacaacccacagcacg
gtgctgggactgtacaacactctgaaccctgaagcatctgcctcgccttgctgcgtgccc
caggacctggagcccctgaccatcctgtactatgttgggaggacccccaaagtggagcag
ctctccaacatggtggtgaagtcttgtaaatgtagctga
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