| Entry |
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| Gene name |
THRA, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, TRalpha, c-ERBA-1
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| Definition |
(RefSeq) thyroid hormone receptor alpha
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| KO |
| K05547 | thyroid hormone receptor alpha |
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| Organism |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04919 | Thyroid hormone signaling pathway |
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| Network |
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| Element |
| N00798 | Thyroid hormone signaling pathway |
| N00799 | Mutation-inactivated THRA to thyroid hormone signaling pathway |
| N00801 | Mutation-inactivated SLC16A2 to thyroid hormone signaling pathway |
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| Disease |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
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| Drug target |
| Liothyronine sodium: | D01011<JP/US> |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
7067 (THRA)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
7067 (THRA)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:hsa03000]
7067 (THRA)
09183 Protein families: signaling and cellular processes
03310 Nuclear receptors [BR:hsa03310]
7067 (THRA)
Transcription factors [BR:hsa03000]
Eukaryotic type
Zinc finger
Cys4 thyroid hormone receptor-like
7067 (THRA)
Nuclear receptors [BR:hsa03310]
1. Thyroid hormone like
1A. Thyroid hormone receptor (THR)
7067 (THRA)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Structure |
PDB: |
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| Position |
17q21.1
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| AA seq |
490 aa
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP |
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| NT seq |
1473 nt +upstreamnt +downstreamnt
atggaacagaagccaagcaaggtggagtgtgggtcagacccagaggagaacagtgccagg
tcaccagatggaaagcgaaaaagaaagaacggccaatgttccctgaaaaccagcatgtca
gggtatatccctagttacctggacaaagacgagcagtgtgtcgtgtgtggggacaaggca
actggttatcactaccgctgtatcacttgtgagggctgcaagggcttctttcgccgcaca
atccagaagaacctccatcccacctattcctgcaaatatgacagctgctgtgtcattgac
aagatcacccgcaatcagtgccagctgtgccgcttcaagaagtgcatcgccgtgggcatg
gccatggacttggttctagatgactcgaagcgggtggccaagcgtaagctgattgagcag
aaccgggagcggcggcggaaggaggagatgatccgatcactgcagcagcgaccagagccc
actcctgaagagtgggatctgatccacattgccacagaggcccatcgcagcaccaatgcc
cagggcagccattggaaacagaggcggaaattcctgcccgatgacattggccagtcaccc
attgtctccatgccggacggagacaaggtggacctggaagccttcagcgagtttaccaag
atcatcaccccggccatcacccgtgtggtggactttgccaaaaaactgcccatgttctcc
gagctgccttgcgaagaccagatcatcctcctgaaggggtgctgcatggagatcatgtcc
ctgcgggcggctgtccgctacgaccctgagagcgacaccctgacgctgagtggggagatg
gctgtcaagcgggagcagctcaagaatggcggcctgggcgtagtctccgacgccatcttt
gaactgggcaagtcactctctgcctttaacctggatgacacggaagtggctctgctgcag
gctgtgctgctaatgtcaacagaccgctcgggcctgctgtgtgtggacaagatcgagaag
agtcaggaggcgtacctgctggcgttcgagcactacgtcaaccaccgcaaacacaacatt
ccgcacttctggcccaagctgctgatgaaggagagagaagtgcagagttcgattctgtac
aagggggcagcggcagaaggccggccgggcgggtcactgggcgtccacccggaaggacag
cagcttctcggaatgcatgttgttcagggtccgcaggtccggcagcttgagcagcagctt
ggtgaagcgggaagtctccaagggccggttcttcagcaccagagcccgaagagcccgcag
cagcgtctcctggagctgctccaccgaagcggaattctccatgcccgagcggtctgtggg
gaagacgacagcagtgaggcggactccccgagctcctctgaggaggaaccggaggtctgc
gaggacctggcaggcaatgcagcctctccctga |
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