Homo sapiens (human): 7097
Entry
7097 CDS
T01001
Gene name
TLR2, CD282, TIL4
Definition
(RefSeq) toll like receptor 2
KO
K10159
toll-like receptor 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04145
Phagosome
hsa04151
PI3K-Akt signaling pathway
hsa04620
Toll-like receptor signaling pathway
hsa05134
Legionellosis
hsa05140
Leishmaniasis
hsa05142
Chagas disease (American trypanosomiasis)
hsa05144
Malaria
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05162
Measles
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05205
Proteoglycans in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321
Inflammatory bowel disease (IBD)
hsa05323
Rheumatoid arthritis
Network
nt06121
TLR signaling (virus)
nt06161
Human immunodeficiency virus type 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06165
Epstein-Barr virus (EBV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06263
Hepatocellular carcinoma
Element
N00435
TLR2/4-NFKB signaling pathway
N00438
TLR2/4-MAPK signaling pathway
N00556
HBV HBe to TLR2/4-NFKB signaling pathway
Disease
H00344
Leprosy
H01358
Atopic dermatitis
Drug target
Tomaralimab:
D11503
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
7097 (TLR2)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
7097 (TLR2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
7097 (TLR2)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
7097 (TLR2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
7097 (TLR2)
09163 Immune disease
05323 Rheumatoid arthritis
7097 (TLR2)
05321 Inflammatory bowel disease (IBD)
7097 (TLR2)
09171 Infectious disease: bacterial
05134 Legionellosis
7097 (TLR2)
05152 Tuberculosis
7097 (TLR2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
7097 (TLR2)
05162 Measles
7097 (TLR2)
05161 Hepatitis B
7097 (TLR2)
05168 Herpes simplex virus 1 infection
7097 (TLR2)
05169 Epstein-Barr virus infection
7097 (TLR2)
09174 Infectious disease: parasitic
05146 Amoebiasis
7097 (TLR2)
05144 Malaria
7097 (TLR2)
05145 Toxoplasmosis
7097 (TLR2)
05140 Leishmaniasis
7097 (TLR2)
05142 Chagas disease (American trypanosomiasis)
7097 (TLR2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
7097 (TLR2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
7097 (TLR2)
04054 Pattern recognition receptors [BR:
hsa04054
]
7097 (TLR2)
04090 CD molecules [BR:
hsa04090
]
7097 (TLR2)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
7097 (TLR2)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Phagocytosis
Toll-like receptors
7097 (TLR2)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of breast milk
7097 (TLR2)
Pattern recognition receptors [BR:
hsa04054
]
Membrane-bound pattern recognition receptors
Toll-like receptors
7097 (TLR2)
CD molecules [BR:
hsa04090
]
Proteins
7097 (TLR2)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Hyaluronan
Cell surface receptors
7097 (TLR2)
SSDB
Motif
Pfam:
LRR_8
TIR
LRR_4
TIR_2
LRR_9
LRR_5
LRR_1
LRRCT
DUF1863
Other DBs
NCBI-GeneID:
7097
NCBI-ProteinID:
NP_001305716
OMIM:
603028
HGNC:
11848
Ensembl:
ENSG00000137462
Vega:
OTTHUMG00000161525
Pharos:
O60603
(Tchem)
UniProt:
O60603
B3KWR9
A0A0S2Z4S4
LinkDB
Structure
PDB:
1FYX
1FYW
1O77
Position
4q31.3
AA seq
784 aa
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLS
NNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWF
KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELE
IDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS
ELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN
DRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK
SLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI
SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK
ELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCE
FLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL
LILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV
QELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS
HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRA
AIKS
NT seq
2355 nt
+upstream
nt +downstream
nt
atgccacatactttgtggatggtgtgggtcttgggggtcatcatcagcctctccaaggaa
gaatcctccaatcaggcttctctgtcttgtgaccgcaatggtatctgcaagggcagctca
ggatctttaaactccattccctcagggctcacagaagctgtaaaaagccttgacctgtcc
aacaacaggatcacctacattagcaacagtgacctacagaggtgtgtgaacctccaggct
ctggtgctgacatccaatggaattaacacaatagaggaagattctttttcttccctgggc
agtcttgaacatttagacttatcctataattacttatctaatttatcgtcttcctggttc
aagcccctttcttctttaacattcttaaacttactgggaaatccttacaaaaccctaggg
gaaacatctcttttttctcatctcacaaaattgcaaatcctgagagtgggaaatatggac
accttcactaagattcaaagaaaagattttgctggacttaccttccttgaggaacttgag
attgatgcttcagatctacagagctatgagccaaaaagtttgaagtcaattcagaatgta
agtcatctgatccttcatatgaagcagcatattttactgctggagatttttgtagatgtt
acaagttccgtggaatgtttggaactgcgagatactgatttggacactttccatttttca
gaactatccactggtgaaacaaattcattgattaaaaagtttacatttagaaatgtgaaa
atcaccgatgaaagtttgtttcaggttatgaaacttttgaatcagatttctggattgtta
gaattagagtttgatgactgtacccttaatggagttggtaattttagagcatctgataat
gacagagttatagatccaggtaaagtggaaacgttaacaatccggaggctgcatattcca
aggttttacttattttatgatctgagcactttatattcacttacagaaagagttaaaaga
atcacagtagaaaacagtaaagtttttctggttccttgtttactttcacaacatttaaaa
tcattagaatacttggatctcagtgaaaatttgatggttgaagaatacttgaaaaattca
gcctgtgaggatgcctggccctctctacaaactttaattttaaggcaaaatcatttggca
tcattggaaaaaaccggagagactttgctcactctgaaaaacttgactaacattgatatc
agtaagaatagttttcattctatgcctgaaacttgtcagtggccagaaaagatgaaatat
ttgaacttatccagcacacgaatacacagtgtaacaggctgcattcccaagacactggaa
attttagatgttagcaacaacaatctcaatttattttctttgaatttgccgcaactcaaa
gaactttatatttccagaaataagttgatgactctaccagatgcctccctcttacccatg
ttactagtattgaaaatcagtaggaatgcaataactacgttttctaaggagcaacttgac
tcatttcacacactgaagactttggaagctggtggcaataacttcatttgctcctgtgaa
ttcctctccttcactcaggagcagcaagcactggccaaagtcttgattgattggccagca
aattacctgtgtgactctccatcccatgtgcgtggccagcaggttcaggatgtccgcctc
tcggtgtcggaatgtcacaggacagcactggtgtctggcatgtgctgtgctctgttcctg
ctgatcctgctcacgggggtcctgtgccaccgtttccatggcctgtggtatatgaaaatg
atgtgggcctggctccaggccaaaaggaagcccaggaaagctcccagcaggaacatctgc
tatgatgcatttgtttcttacagtgagcgggatgcctactgggtggagaaccttatggtc
caggagctggagaacttcaatccccccttcaagttgtgtcttcataagcgggacttcatt
cctggcaagtggatcattgacaatatcattgactccattgaaaagagccacaaaactgtc
tttgtgctttctgaaaactttgtgaagagtgagtggtgcaagtatgaactggacttctcc
catttccgtctttttgatgagaacaatgatgctgccattctcattcttctggagcccatt
gagaaaaaagccattccccagcgcttctgcaagctgcggaagataatgaacaccaagacc
tacctggagtggcccatggacgaggctcagcgggaaggattttgggtaaatctgagagct
gcgataaagtcctag
DBGET
integrated database retrieval system
