Entry |
|
Gene name |
TLR2, CD282, TIL4
|
Definition |
(RefSeq) toll like receptor 2
|
KO |
|
Organism |
|
Pathway |
hsa04613 | Neutrophil extracellular trap formation |
hsa04620 | Toll-like receptor signaling pathway |
hsa05168 | Herpes simplex virus 1 infection |
hsa05170 | Human immunodeficiency virus 1 infection |
hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
|
Network |
nt06121 TLR signaling (viruses and bacteria) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06165 Epstein-Barr virus (EBV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06263 Hepatocellular carcinoma |
Element |
N00435 | TLR2/4-NFKB signaling pathway |
N00438 | TLR2/4-MAPK signaling pathway |
N00556 | HBV HBe to TLR2/4-NFKB signaling pathway |
|
Disease |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
7097 (TLR2)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
7097 (TLR2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
7097 (TLR2)
04620 Toll-like receptor signaling pathway
7097 (TLR2)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
7097 (TLR2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
7097 (TLR2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
7097 (TLR2)
05161 Hepatitis B
7097 (TLR2)
05171 Coronavirus disease - COVID-19
7097 (TLR2)
05162 Measles
7097 (TLR2)
05168 Herpes simplex virus 1 infection
7097 (TLR2)
05169 Epstein-Barr virus infection
7097 (TLR2)
09171 Infectious disease: bacterial
05132 Salmonella infection
7097 (TLR2)
05134 Legionellosis
7097 (TLR2)
05152 Tuberculosis
7097 (TLR2)
09174 Infectious disease: parasitic
05146 Amoebiasis
7097 (TLR2)
05144 Malaria
7097 (TLR2)
05145 Toxoplasmosis
7097 (TLR2)
05140 Leishmaniasis
7097 (TLR2)
05142 Chagas disease
7097 (TLR2)
09163 Immune disease
05323 Rheumatoid arthritis
7097 (TLR2)
05321 Inflammatory bowel disease
7097 (TLR2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
7097 (TLR2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
7097 (TLR2)
04054 Pattern recognition receptors [BR:hsa04054]
7097 (TLR2)
04090 CD molecules [BR:hsa04090]
7097 (TLR2)
00536 Glycosaminoglycan binding proteins [BR:hsa00536]
7097 (TLR2)
Membrane trafficking [BR:hsa04131]
Endocytosis
Phagocytosis
Toll-like receptors
7097 (TLR2)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of breast milk
7097 (TLR2)
Pattern recognition receptors [BR:hsa04054]
Membrane-bound pattern recognition receptors
Toll-like receptors
7097 (TLR2)
CD molecules [BR:hsa04090]
Proteins
7097 (TLR2)
Glycosaminoglycan binding proteins [BR:hsa00536]
Hyaluronan
Cell surface receptors
7097 (TLR2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Structure |
PDB: |
Position |
4q31.3
|
AA seq |
784 aa
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLS
NNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWF
KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELE
IDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS
ELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN
DRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK
SLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI
SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK
ELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCE
FLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL
LILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV
QELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS
HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRA
AIKS |
NT seq |
2355 nt +upstreamnt +downstreamnt
atgccacatactttgtggatggtgtgggtcttgggggtcatcatcagcctctccaaggaa
gaatcctccaatcaggcttctctgtcttgtgaccgcaatggtatctgcaagggcagctca
ggatctttaaactccattccctcagggctcacagaagctgtaaaaagccttgacctgtcc
aacaacaggatcacctacattagcaacagtgacctacagaggtgtgtgaacctccaggct
ctggtgctgacatccaatggaattaacacaatagaggaagattctttttcttccctgggc
agtcttgaacatttagacttatcctataattacttatctaatttatcgtcttcctggttc
aagcccctttcttctttaacattcttaaacttactgggaaatccttacaaaaccctaggg
gaaacatctcttttttctcatctcacaaaattgcaaatcctgagagtgggaaatatggac
accttcactaagattcaaagaaaagattttgctggacttaccttccttgaggaacttgag
attgatgcttcagatctacagagctatgagccaaaaagtttgaagtcaattcagaatgta
agtcatctgatccttcatatgaagcagcatattttactgctggagatttttgtagatgtt
acaagttccgtggaatgtttggaactgcgagatactgatttggacactttccatttttca
gaactatccactggtgaaacaaattcattgattaaaaagtttacatttagaaatgtgaaa
atcaccgatgaaagtttgtttcaggttatgaaacttttgaatcagatttctggattgtta
gaattagagtttgatgactgtacccttaatggagttggtaattttagagcatctgataat
gacagagttatagatccaggtaaagtggaaacgttaacaatccggaggctgcatattcca
aggttttacttattttatgatctgagcactttatattcacttacagaaagagttaaaaga
atcacagtagaaaacagtaaagtttttctggttccttgtttactttcacaacatttaaaa
tcattagaatacttggatctcagtgaaaatttgatggttgaagaatacttgaaaaattca
gcctgtgaggatgcctggccctctctacaaactttaattttaaggcaaaatcatttggca
tcattggaaaaaaccggagagactttgctcactctgaaaaacttgactaacattgatatc
agtaagaatagttttcattctatgcctgaaacttgtcagtggccagaaaagatgaaatat
ttgaacttatccagcacacgaatacacagtgtaacaggctgcattcccaagacactggaa
attttagatgttagcaacaacaatctcaatttattttctttgaatttgccgcaactcaaa
gaactttatatttccagaaataagttgatgactctaccagatgcctccctcttacccatg
ttactagtattgaaaatcagtaggaatgcaataactacgttttctaaggagcaacttgac
tcatttcacacactgaagactttggaagctggtggcaataacttcatttgctcctgtgaa
ttcctctccttcactcaggagcagcaagcactggccaaagtcttgattgattggccagca
aattacctgtgtgactctccatcccatgtgcgtggccagcaggttcaggatgtccgcctc
tcggtgtcggaatgtcacaggacagcactggtgtctggcatgtgctgtgctctgttcctg
ctgatcctgctcacgggggtcctgtgccaccgtttccatggcctgtggtatatgaaaatg
atgtgggcctggctccaggccaaaaggaagcccaggaaagctcccagcaggaacatctgc
tatgatgcatttgtttcttacagtgagcgggatgcctactgggtggagaaccttatggtc
caggagctggagaacttcaatccccccttcaagttgtgtcttcataagcgggacttcatt
cctggcaagtggatcattgacaatatcattgactccattgaaaagagccacaaaactgtc
tttgtgctttctgaaaactttgtgaagagtgagtggtgcaagtatgaactggacttctcc
catttccgtctttttgatgagaacaatgatgctgccattctcattcttctggagcccatt
gagaaaaaagccattccccagcgcttctgcaagctgcggaagataatgaacaccaagacc
tacctggagtggcccatggacgaggctcagcgggaaggattttgggtaaatctgagagct
gcgataaagtcctag |