Homo sapiens (human): 7422
Help
Entry
7422 CDS
T01001
Gene name
VEGFA, MVCD1, VEGF, VPF
Definition
(RefSeq) vascular endothelial growth factor A
KO
K05448
vascular endothelial growth factor A
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04370
VEGF signaling pathway
hsa04510
Focal adhesion
hsa04926
Relaxin signaling pathway
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05163
Human cytomegalovirus infection
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05219
Bladder cancer
hsa05323
Rheumatoid arthritis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06114
PI3K signaling (viruses)
nt06124
Chemokine signaling (viruses)
nt06150
Cytokine-cytokine receptor interaction (viruses)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06214
PI3K signaling
nt06219
JAK-STAT signaling
nt06224
CXCR signaling
nt06225
HIF-1 signaling
nt06262
Pancreatic cancer
nt06264
Renal cell carcinoma
Element
N00079
HIF-1 signaling pathway
N00080
Loss of VHL to HIF-1 signaling pathway
N00081
Mutation-inactivated VHL to HIF-1 signaling pathway
N00095
ERBB2-overexpression to EGF-Jak-STAT signaling pathway
N00157
KSHV vGPCR to GNB/G-ERK signaling pathway
N00179
KSHV K1 to PI3K-NFKB signaling pathway
Disease
H01456
Diabetic nephropathy
H01457
Diabetic retinopathy
H01459
Diabetic neuropathy
H01529
Avascular necrosis of femoral head
H01709
Glucocorticoid-induced osteonecrosis
Drug target
Abicipar pegol:
D11517
Aflibercept:
D09574
<JP/US>
Aflibercept beta:
D10819
<JP>
Bevacizumab:
D06409
<JP/US>
Bevasiranib sodium:
D08874
Brolucizumab:
D11083
<JP>
Dilpacimab:
D11642
Emvododstat:
D11890
Faricimab:
D11516
Navicixizumab:
D11126
Pegaptanib:
D05386
Ranibizumab:
D05697
<JP/US>
Vanucizumab:
D11244
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
7422 (VEGFA)
04014 Ras signaling pathway
7422 (VEGFA)
04015 Rap1 signaling pathway
7422 (VEGFA)
04370 VEGF signaling pathway
7422 (VEGFA)
04066 HIF-1 signaling pathway
7422 (VEGFA)
04020 Calcium signaling pathway
7422 (VEGFA)
04151 PI3K-Akt signaling pathway
7422 (VEGFA)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
7422 (VEGFA)
09150 Organismal Systems
09152 Endocrine system
04926 Relaxin signaling pathway
7422 (VEGFA)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
7422 (VEGFA)
05206 MicroRNAs in cancer
7422 (VEGFA)
05205 Proteoglycans in cancer
7422 (VEGFA)
09162 Cancer: specific types
05212 Pancreatic cancer
7422 (VEGFA)
05211 Renal cell carcinoma
7422 (VEGFA)
05219 Bladder cancer
7422 (VEGFA)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
7422 (VEGFA)
05167 Kaposi sarcoma-associated herpesvirus infection
7422 (VEGFA)
05165 Human papillomavirus infection
7422 (VEGFA)
09163 Immune disease
05323 Rheumatoid arthritis
7422 (VEGFA)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
7422 (VEGFA)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
7422 (VEGFA)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
7422 (VEGFA)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and growth factors [BR:
hsa04052
]
7422 (VEGFA)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
7422 (VEGFA)
Cytokines and growth factors [BR:
hsa04052
]
Growth factors
Growth factors (RTK binding)
7422 (VEGFA)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Growth factors/receptors
7422 (VEGFA)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
VEGF_C
PDGF
Motif
Other DBs
NCBI-GeneID:
7422
NCBI-ProteinID:
NP_001165094
OMIM:
192240
HGNC:
12680
Ensembl:
ENSG00000112715
Vega:
OTTHUMG00000014745
Pharos:
P15692
(Tclin)
UniProt:
P15692
A0A024RD33
LinkDB
All DBs
Structure
PDB:
1MKK
4GLN
4GLS
1FLT
4KZN
4QAF
3QTK
1VPP
2VPF
5DN2
5HHC
5HHD
1MJV
5O4E
1CZ8
1BJ1
3P9W
1MKG
1VPF
6BFT
3S1K
3BDY
1TZH
5FV1
1QTY
4ZFF
2FJG
1TZI
3S1B
6D3O
2FJH
4WPB
3V2A
5FV2
2QR0
5T89
1KMX
1KAT
1VGH
2VGH
Thumbnails
Position
6p21.1
AA seq
232 aa
AA seq
DB search
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
NT seq
699 nt
NT seq
+upstream
nt +downstream
nt
atgaactttctgctgtcttgggtgcattggagccttgccttgctgctctacctccaccat
gccaagtggtcccaggctgcacccatggcagaaggaggagggcagaatcatcacgaagtg
gtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagaccctggtggac
atcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctg
atgcgatgcgggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtcc
aacatcaccatgcagattatgcggatcaaacctcaccaaggccagcacataggagagatg
agcttcctacagcacaacaaatgtgaatgcagaccaaagaaagatagagcaagacaagaa
aaaaaatcagttcgaggaaagggaaaggggcaaaaacgaaagcgcaagaaatcccggtat
aagtcctggagcgtgtacgttggtgcccgctgctgtctaatgccctggagcctccctggc
ccccatccctgtgggccttgctcagagcggagaaagcatttgtttgtacaagatccgcag
acgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcagcttgagtta
aacgaacgtacttgcagatgtgacaagccgaggcggtga
Homo sapiens (human): 5155
Help
Entry
5155 CDS
T01001
Gene name
PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis
Definition
(RefSeq) platelet derived growth factor subunit B
KO
K17386
platelet-derived growth factor subunit B
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04510
Focal adhesion
hsa04540
Gap junction
hsa04630
JAK-STAT signaling pathway
hsa04810
Regulation of actin cytoskeleton
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05200
Pathways in cancer
hsa05206
MicroRNAs in cancer
hsa05211
Renal cell carcinoma
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05231
Choline metabolism in cancer
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06110
MAPK signaling (viruses and bacteria)
nt06114
PI3K signaling (viruses)
nt06124
Chemokine signaling (viruses)
nt06150
Cytokine-cytokine receptor interaction (viruses)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06210
ERK signaling
nt06214
PI3K signaling
nt06220
Calcium signaling
nt06224
CXCR signaling
nt06225
HIF-1 signaling
nt06264
Renal cell carcinoma
nt06273
Glioma
Element
N00015
PDGF-PDGFR-RAS-ERK signaling pathway
N00016
PDGF-overexpression to RAS-ERK signaling pathway
N00028
PDGF-PDGFR-PLCG-CAMK signaling pathway
N00039
PDGF-PDGFR-PI3K signaling pathway
N00079
HIF-1 signaling pathway
N00080
Loss of VHL to HIF-1 signaling pathway
N00081
Mutation-inactivated VHL to HIF-1 signaling pathway
N00157
KSHV vGPCR to GNB/G-ERK signaling pathway
Disease
H00015
Malignant pleural mesothelioma
H00042
Glioma
H01574
Familial idiopathic basal ganglia calcification
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5155 (PDGFB)
04014 Ras signaling pathway
5155 (PDGFB)
04015 Rap1 signaling pathway
5155 (PDGFB)
04630 JAK-STAT signaling pathway
5155 (PDGFB)
04020 Calcium signaling pathway
5155 (PDGFB)
04072 Phospholipase D signaling pathway
5155 (PDGFB)
04151 PI3K-Akt signaling pathway
5155 (PDGFB)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
5155 (PDGFB)
04540 Gap junction
5155 (PDGFB)
09142 Cell motility
04810 Regulation of actin cytoskeleton
5155 (PDGFB)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5155 (PDGFB)
05206 MicroRNAs in cancer
5155 (PDGFB)
05231 Choline metabolism in cancer
5155 (PDGFB)
09162 Cancer: specific types
05214 Glioma
5155 (PDGFB)
05218 Melanoma
5155 (PDGFB)
05211 Renal cell carcinoma
5155 (PDGFB)
05215 Prostate cancer
5155 (PDGFB)
09172 Infectious disease: viral
05167 Kaposi sarcoma-associated herpesvirus infection
5155 (PDGFB)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
5155 (PDGFB)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
5155 (PDGFB)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and growth factors [BR:
hsa04052
]
5155 (PDGFB)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
5155 (PDGFB)
Cytokines and growth factors [BR:
hsa04052
]
Growth factors
Growth factors (RTK binding)
5155 (PDGFB)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Growth factors/receptors
5155 (PDGFB)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PDGF
PDGF_N
Motif
Other DBs
NCBI-GeneID:
5155
NCBI-ProteinID:
NP_002599
OMIM:
190040
HGNC:
8800
Ensembl:
ENSG00000100311
Vega:
OTTHUMG00000151029
Pharos:
P01127
(Tchem)
UniProt:
P01127
A0A384NYY3
LinkDB
All DBs
Structure
PDB:
4HQU
4QCI
4HQX
3MJG
1PDG
Thumbnails
Position
22q13.1
AA seq
241 aa
AA seq
DB search
MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAEL
DLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLV
WPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKC
ETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLG
A
NT seq
726 nt
NT seq
+upstream
nt +downstream
nt
atgaatcgctgctgggcgctcttcctgtctctctgctgctacctgcgtctggtcagcgcc
gagggggaccccattcccgaggagctttatgagatgctgagtgaccactcgatccgctcc
tttgatgatctccaacgcctgctgcacggagaccccggagaggaagatggggccgagttg
gacctgaacatgacccgctcccactctggaggcgagctggagagcttggctcgtggaaga
aggagcctgggttccctgaccattgctgagccggccatgatcgccgagtgcaagacgcgc
accgaggtgttcgagatctcccggcgcctcatagaccgcaccaacgccaacttcctggtg
tggccgccctgtgtggaggtgcagcgctgctccggctgctgcaacaaccgcaacgtgcag
tgccgccccacccaggtgcagctgcgacctgtccaggtgagaaagatcgagattgtgcgg
aagaagccaatctttaagaaggccacggtgacgctggaagaccacctggcatgcaagtgt
gagacagtggcagctgcacggcctgtgacccgaagcccggggggttcccaggagcagcga
gccaaaacgccccaaactcgggtgaccattcggacggtgcgagtccgccggccccccaag
ggcaagcaccggaaattcaagcacacgcatgacaagacggcactgaaggagacccttgga
gcctag
Homo sapiens (human): 285
Help
Entry
285 CDS
T01001
Gene name
ANGPT2, AGPT2, ANG2
Definition
(RefSeq) angiopoietin 2
KO
K05466
angiopoietin 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa05167
Kaposi sarcoma-associated herpesvirus infection
Network
nt06124
Chemokine signaling (viruses)
nt06150
Cytokine-cytokine receptor interaction (viruses)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06224
CXCR signaling
Element
N00157
KSHV vGPCR to GNB/G-ERK signaling pathway
Drug target
Faricimab:
D11516
Nesvacumab:
D10395
Trebananib:
D10177
Vanucizumab:
D11244
Zansecimab:
D11904
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
285 (ANGPT2)
04014 Ras signaling pathway
285 (ANGPT2)
04015 Rap1 signaling pathway
285 (ANGPT2)
04066 HIF-1 signaling pathway
285 (ANGPT2)
04151 PI3K-Akt signaling pathway
285 (ANGPT2)
09160 Human Diseases
09172 Infectious disease: viral
05167 Kaposi sarcoma-associated herpesvirus infection
285 (ANGPT2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and growth factors [BR:
hsa04052
]
285 (ANGPT2)
Cytokines and growth factors [BR:
hsa04052
]
Growth factors
Growth factors (RTK binding)
285 (ANGPT2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Fibrinogen_C
DUF5713
Motif
Other DBs
NCBI-GeneID:
285
NCBI-ProteinID:
NP_001138
OMIM:
601922
HGNC:
485
Ensembl:
ENSG00000091879
Vega:
OTTHUMG00000090365
Pharos:
O15123
(Tbio)
UniProt:
O15123
LinkDB
All DBs
Structure
PDB:
4JZC
1Z3U
4ZFG
1Z3S
2GY7
Thumbnails
Position
8p23.1
AA seq
496 aa
AA seq
DB search
MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPY
VSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQ
TAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSE
INKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVN
NSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTL
TFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFV
SQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPG
NDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGS
GYSLKATTMMIRPADF
NT seq
1491 nt
NT seq
+upstream
nt +downstream
nt
atgtggcagattgttttctttactctgagctgtgatcttgtcttggccgcagcctataac
aactttcggaagagcatggacagcataggaaagaagcaatatcaggtccagcatgggtcc
tgcagctacactttcctcctgccagagatggacaactgccgctcttcctccagcccctac
gtgtccaatgctgtgcagagggacgcgccgctcgaatacgatgactcggtgcagaggctg
caagtgctggagaacatcatggaaaacaacactcagtggctaatgaagcttgagaattat
atccaggacaacatgaagaaagaaatggtagagatacagcagaatgcagtacagaaccag
acggctgtgatgatagaaatagggacaaacctgttgaaccaaacagcggagcaaacgcgg
aagttaactgatgtggaagcccaagtattaaatcagaccacgagacttgaacttcagctc
ttggaacactccctctcgacaaacaaattggaaaaacagattttggaccagaccagtgaa
ataaacaaattgcaagataagaacagtttcctagaaaagaaggtgctagctatggaagac
aagcacatcatccaactacagtcaataaaagaagagaaagatcagctacaggtgttagta
tccaagcaaaattccatcattgaagaactagaaaaaaaaatagtgactgccacggtgaat
aattcagttcttcagaagcagcaacatgatctcatggagacagttaataacttactgact
atgatgtccacatcaaactcagctaaggaccccactgttgctaaagaagaacaaatcagc
ttcagagactgtgctgaagtattcaaatcaggacacaccacgaatggcatctacacgtta
acattccctaattctacagaagagatcaaggcctactgtgacatggaagctggaggaggc
gggtggacaattattcagcgacgtgaggatggcagcgttgattttcagaggacttggaaa
gaatataaagtgggatttggtaacccttcaggagaatattggctgggaaatgagtttgtt
tcgcaactgactaatcagcaacgctatgtgcttaaaatacaccttaaagactgggaaggg
aatgaggcttactcattgtatgaacatttctatctctcaagtgaagaactcaattatagg
attcaccttaaaggacttacagggacagccggcaaaataagcagcatcagccaaccagga
aatgattttagcacaaaggatggagacaacgacaaatgtatttgcaaatgttcacaaatg
ctaacaggaggctggtggtttgatgcatgtggtccttccaacttgaacggaatgtactat
ccacagaggcagaacacaaataagttcaacggcattaaatggtactactggaaaggctca
ggctattcgctcaaggccacaaccatgatgatccgaccagcagatttctaa
DBGET
integrated database retrieval system