Homo sapiens (human): 7498 Help Entry 7498              CDS       T01001                                  Gene name XDH, XAN1, XO, XOR Definition (RefSeq) xanthine dehydrogenase   KO K00106   xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2] Organism hsa  Homo sapiens (human) Pathway hsa00230   Purine metabolism hsa00232   Caffeine metabolism hsa00983   Drug metabolism - other enzymes hsa01100   Metabolic pathways hsa04146   Peroxisome Network nt06025  Molybdenum cofactor biosynthesis   Element N00888   Hypoxanthine oxidation N00889   XDH deficiency in hypoxanthine oxidation Disease H00192   Xanthinuria Drug target Allopurinol (DG00779):  D00224<JP/US> D07564<US> Amflutizole:  D02896 Febuxostat (DG02878):  D01206<JP/US> D11081<US> Oxypurinol:  D02365 Topiroxostat:  D09786<JP> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     7498 (XDH)   09110 Biosynthesis of other secondary metabolites    00232 Caffeine metabolism     7498 (XDH)   09111 Xenobiotics biodegradation and metabolism    00983 Drug metabolism - other enzymes     7498 (XDH)  09140 Cellular Processes   09141 Transport and catabolism    04146 Peroxisome     7498 (XDH)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     7498 (XDH) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.17  Acting on CH or CH2 groups    1.17.1  With NAD+ or NADP+ as acceptor     1.17.1.4  xanthine dehydrogenase      7498 (XDH)    1.17.3  With oxygen as acceptor     1.17.3.2  xanthine oxidase      7498 (XDH) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of breast milk    7498 (XDH) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ald_Xan_dh_C2 FAD_binding_5 Ald_Xan_dh_C Fer2_2 CO_deh_flav_C Fer2 DHODB_Fe-S_bind Motif Other DBs NCBI-GeneID:  7498 NCBI-ProteinID:  NP_000370 OMIM:  607633 HGNC:  12805 Ensembl:  ENSG00000158125 Vega:  OTTHUMG00000099385 Pharos:  P47989(Tclin) UniProt:  P47989 LinkDB All DBs Structure PDB:  2E1Q 2CKJ Thumbnails Position 2p23.1 AA seq 1333 aa AA seqDB search MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDR LQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGI VMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCC MNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQAS TLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFG AACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISD LNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSA FKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKE ELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLD PTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRY ENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICNDETVFAKDK VTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDL KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKM LGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGR HPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGR LCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKL EGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGA LLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAA SVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLG YSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAF VQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAV GEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKFTTLCVT GVPENCKPWSVRV NT seq 4002 nt NT seq  +upstreamnt  +downstreamnt atgacagcagacaaattggttttctttgtgaatggcagaaaggtggtggagaaaaatgca gatccagagacaacccttttggcctacctgagaagaaagttggggctgagtggaaccaag ctcggctgtggagaggggggctgcggggcttgcacagtgatgctctccaagtatgatcgt ctgcagaacaagatcgtccacttttctgccaatgcctgcctggcccccatctgctccttg caccatgttgcagtgacaactgtggaaggaataggaagcaccaagacgaggctgcatcct gtgcaggagagaattgccaaaagccacggctcccagtgcgggttctgcacccctggcatc gtcatgagtatgtacacactgctccggaatcagcccgagcccaccatggaggagattgag aatgccttccaaggaaatctgtgccgctgcacaggctacagacccatcctccagggcttc cggacctttgccagggatggtggatgctgtggaggagatgggaataatccaaattgctgc atgaaccagaagaaagaccactcagtcagcctctcgccatctttattcaaaccagaggag ttcacgcccctggatccaacccaggagcccatttttcccccagagttgctgaggctgaaa gacactcctcggaagcagctgcgatttgaaggggagcgtgtgacgtggatacaggcctca accctcaaggagctgctggacctcaaggctcagcaccctgacgccaagctggtcgtgggg aacacggagattggcattgagatgaagttcaagaatatgctgtttcctatgattgtctgc ccagcctggatccctgagctgaattcggtagaacatggacccgacggtatctcctttgga gctgcttgccccctgagcattgtggaaaaaaccctggtggatgctgttgctaagcttcct gcccaaaagacagaggtgttcagaggggtcctggagcagctgcgctggtttgctgggaag caagtcaagtctgtggcgtccgttggagggaacatcatcactgccagccccatctccgac ctcaaccccgtgttcatggccagtggggccaagctgacacttgtgtccagaggcaccagg agaactgtccagatggaccacaccttcttccctggctacagaaagaccctgctgagcccg gaggagatactgctctccatagagatcccctacagcagggagggggagtatttctcagca ttcaagcaggcctcccggagagaagatgacattgccaaggtaaccagtggcatgagagtt ttattcaagccaggaaccacagaggtacaggagctggccctttgctatggtggaatggcc aacagaaccatctcagccctcaagaccactcagaggcagctttccaagctctggaaggag gagctgctgcaggacgtgtgtgcaggactggcagaggagctgcatctgcctcccgatgcc cctggtggcatggtggacttccggtgcaccctcaccctcagcttcttcttcaagttctac ctgacagtccttcagaagctgggccaagagaacctggaagacaagtgtggtaaactggac cccactttcgccagtgcaactttactgtttcagaaagaccccccagccgatgtccagctc ttccaagaggtgcccaagggtcagtctgaggaggacatggtgggccggcccctgccccac ctggcagcggacatgcaggcctctggtgaggccgtgtactgtgacgacattcctcgctac gagaatgagctgtctctccggctggtcaccagcacccgggcccacgccaagatcaagtcc atagatacatcagaagctaagaaggttccagggtttgtttgtttcatttccgctgatgat gttcctgggagtaacataactggaatttgtaatgatgagacagtctttgcgaaggataag gttacttgtgttgggcatatcattggtgctgtggttgctgacaccccggaacacacacag agagctgcccaaggggtgaaaatcacctatgaagaactaccagccattatcacaattgag gatgctataaagaacaactccttttatggacctgagctgaagatcgagaaaggggaccta aagaaggggttttccgaagcagataatgttgtgtcaggggagatatacatcggtggccaa gagcacttctacctggagactcactgcaccattgctgttccaaaaggcgaggcaggggag atggagctctttgtgtctacacagaacaccatgaagacccagagctttgttgcaaaaatg ttgggggttccagcaaaccggattgtggttcgagtgaagagaatgggaggaggctttgga ggcaaggagacccggagcactgtggtgtccacggcagtggccctggctgcatataagacc ggccgccctgtgcgatgcatgctggaccgtgatgaggacatgctgataactggtggcaga catcccttcctggccagatacaaggttggcttcatgaagactgggacagttgtggctctt gaggtggaccacttcagcaatgtggggaacacccaggatctctctcagagtattatggaa cgagctttattccacatggacaactgctataaaatccccaacatccggggcactgggcgg ctgtgcaaaaccaaccttccctccaacacggccttccggggctttggggggccccagggg atgctcattgccgagtgctggatgagtgaagttgcagtgacctgtgggatgcctgcagag gaggtgcggagaaaaaacctgtacaaagaaggggacctgacacacttcaaccagaagctt gagggtttcaccttgcccagatgctgggaagaatgcctagcaagctctcagtatcatgct cggaagagtgaggttgacaagttcaacaaggagaattgttggaaaaagagaggattgtgc ataattcccaccaagtttggaataagctttacagttccttttctgaatcaggcaggagcc ctacttcatgtgtacacagatggctctgtgctgctgacccacggggggactgagatgggc caaggccttcataccaaaatggtccaggtggccagtagagctctgaaaatccccacctct aagatttatatcagcgagacaagcactaacactgtgcccaacacctctcccacggctgcc tctgtcagcgctgacctcaatggacaggccgtctatgcggcttgtcagaccatcttgaaa aggctggaaccctacaagaagaagaatcccagtggctcctgggaagactgggtcacagct gcctacatggacacagtgagcttgtctgccactgggttttatagaacacccaatctgggc tacagctttgagactaactcagggaaccccttccactacttcagctatggggtggcttgc tctgaagtagaaatcgactgcctaacaggagatcataagaacctccgcacagatattgtc atggatgttggctccagtctaaaccctgccattgatattggacaggtggaaggggcattt gtccagggccttggcctcttcaccctagaggagctacactattcccccgaggggagcctg cacacccgtggccctagcacctacaagatcccggcatttggcagcatccccattgagttc agggtgtccctgctccgcgactgccccaacaagaaggccatctatgcatcgaaggctgtt ggagagccgcccctcttcctggctgcttctatcttctttgccatcaaagatgccatccgt gcagctcgagctcagcacacaggtaataacgtgaaggaactcttccggctagacagccct gccaccccggagaagatccgcaatgcctgcgtggacaagttcaccaccctgtgtgtcact ggtgtcccagaaaactgcaaaccctggtctgtgagggtctaa

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