KEGG   Homo sapiens (human): 7846
Entry
7846              CDS       T01001                                 

Gene name
TUBA1A, B-ALPHA-1, LIS3, TUBA3
Definition
(RefSeq) tubulin alpha 1a
  KO
K07374  tubulin alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04530  Tight junction
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H00268  Lissencephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7846 (TUBA1A)
  09143 Cell growth and death
   04210 Apoptosis
    7846 (TUBA1A)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    7846 (TUBA1A)
   04540 Gap junction
    7846 (TUBA1A)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7846 (TUBA1A)
   05012 Parkinson disease
    7846 (TUBA1A)
   05014 Amyotrophic lateral sclerosis
    7846 (TUBA1A)
   05016 Huntington disease
    7846 (TUBA1A)
   05020 Prion disease
    7846 (TUBA1A)
   05022 Pathways of neurodegeneration - multiple diseases
    7846 (TUBA1A)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    7846 (TUBA1A)
   05132 Salmonella infection
    7846 (TUBA1A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    7846 (TUBA1A)
   03036 Chromosome and associated proteins [BR:hsa03036]
    7846 (TUBA1A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7846 (TUBA1A)
   04147 Exosome [BR:hsa04147]
    7846 (TUBA1A)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     7846 (TUBA1A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     7846 (TUBA1A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    7846 (TUBA1A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   7846 (TUBA1A)
  Exosomal proteins of other body fluids (saliva and urine)
   7846 (TUBA1A)
  Exosomal proteins of colorectal cancer cells
   7846 (TUBA1A)
SSDB
Motif
Pfam: Tubulin Tubulin_C Tubulin_3
Other DBs
NCBI-GeneID: 7846
NCBI-ProteinID: NP_001257328
OMIM: 602529
HGNC: 20766
Ensembl: ENSG00000167552
Vega: OTTHUMG00000169511
Pharos: Q71U36(Tchem)
UniProt: Q71U36
LinkDB
Structure
PDB: 
5JCO 2E4H

Position
12q13.12
AA seq 451 aa
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
NT seq 1356 nt   +upstreamnt  +downstreamnt
atgcgtgagtgcatctccatccacgttggccaggctggtgtccagattggcaatgcctgc
tgggagctctactgcctggaacacggcatccagcccgatggccagatgccaagtgacaag
accattgggggaggagatgattccttcaacaccttcttcagtgagacgggggctggcaag
catgtgccccgggcagtgtttgtagacttggaacccacagtcattgatgaagttcgcact
ggcacctaccgccagctcttccaccctgagcaacttatcacaggcaaagaagatgctgcc
aataactatgcccgagggcactacaccattggcaaggagatcattgacctcgtgttggac
cgaattcgcaagctggccgaccagtgcacgggtctccagggcttcttggttttccacagc
tttggtgggggaactggttctgggttcacctcgctgctcatggaacgtctctcagttgat
tatggcaagaagtccaagctggagttctctatttacccggcgccccaggtttccacagct
gtagttgagccctacaactccatcctcaccacccacaccaccctggagcactctgattgt
gccttcatggtagacaatgaggccatctatgacatctgtcgtagaaacctcgatattgag
cgtccaacctatactaacctgaataggttaataggtcaaattgtgtcctccatcactgct
tccctgagatttgatggagccctgaatgttgacctgacagaattccagaccaacctggtg
ccctatccccgcatccacttccctctggccacatatgcccctgtcatctctgctgagaaa
gcctaccatgaacagctttctgtagcagagatcaccaatgcttgctttgagccagccaac
cagatggtgaaatgtgaccctcgccatggtaaatacatggcttgctgcctgttgtaccgt
ggtgacgtggttcccaaagatgtcaatgctgccattgccaccatcaagaccaagcgtacc
atccagtttgtggattggtgccccactggcttcaaggttggcatcaactaccagcctccc
actgtggtgcctggtggagacctggccaaggtacagagagctgtgtgcatgctgagcaac
accacagccattgctgaggcctgggctcgcctggaccacaagtttgacctgatgtatgcc
aaacgtgcctttgttcactggtacgttggggaggggatggaggaaggtgagttttcagag
gcccgtgaggacatggctgcccttgagaaggattatgaggaggttggtgtggattctgtt
gaaggagagggtgaggaagaaggagaggaatactaa

KEGG   Homo sapiens (human): 10376
Entry
10376             CDS       T01001                                 

Gene name
TUBA1B, K-ALPHA-1
Definition
(RefSeq) tubulin alpha 1b
  KO
K07374  tubulin alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04530  Tight junction
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    10376 (TUBA1B)
  09143 Cell growth and death
   04210 Apoptosis
    10376 (TUBA1B)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    10376 (TUBA1B)
   04540 Gap junction
    10376 (TUBA1B)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10376 (TUBA1B)
   05012 Parkinson disease
    10376 (TUBA1B)
   05014 Amyotrophic lateral sclerosis
    10376 (TUBA1B)
   05016 Huntington disease
    10376 (TUBA1B)
   05020 Prion disease
    10376 (TUBA1B)
   05022 Pathways of neurodegeneration - multiple diseases
    10376 (TUBA1B)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10376 (TUBA1B)
   05132 Salmonella infection
    10376 (TUBA1B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    10376 (TUBA1B)
   03036 Chromosome and associated proteins [BR:hsa03036]
    10376 (TUBA1B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10376 (TUBA1B)
   04147 Exosome [BR:hsa04147]
    10376 (TUBA1B)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     10376 (TUBA1B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     10376 (TUBA1B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    10376 (TUBA1B)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   10376 (TUBA1B)
  Exosomal proteins of other body fluids (saliva and urine)
   10376 (TUBA1B)
  Exosomal proteins of colorectal cancer cells
   10376 (TUBA1B)
SSDB
Motif
Pfam: Tubulin Tubulin_C Tubulin_3
Other DBs
NCBI-GeneID: 10376
NCBI-ProteinID: NP_006073
OMIM: 602530
HGNC: 18809
Ensembl: ENSG00000123416
Vega: OTTHUMG00000170410
Pharos: P68363(Tchem)
UniProt: P68363
LinkDB
Structure
PDB: 

Position
12q13.12
AA seq 451 aa
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
NT seq 1356 nt   +upstreamnt  +downstreamnt
atgcgtgagtgcatctccatccacgttggccaggctggtgtccagattggcaatgcctgc
tgggagctctactgcctggaacacggcatccagcccgatggccagatgccaagtgacaag
accattgggggaggagatgactccttcaacaccttcttcagtgagacgggcgctggcaag
cacgtgccccgggctgtgtttgtagacttggaacccacagtcattgatgaagttcgcact
ggcacctaccgccagctcttccaccctgagcagctcatcacaggcaaggaagatgctgcc
aataactatgcccgagggcactacaccattggcaaggagatcattgaccttgtgttggac
cgaattcgcaagctggctgaccagtgcaccggtcttcagggcttcttggttttccacagc
tttggtgggggaactggttctgggttcacctccctgctcatggaacgtctctcagttgat
tatggcaagaagtccaagctggagttctccatttacccagcaccccaggtttccacagct
gtagttgagccctacaactccatcctcaccacccacaccaccctggagcactctgattgt
gccttcatggtagacaatgaggccatctatgacatctgtcgtagaaacctcgatatcgag
cgcccaacctacactaaccttaaccgccttattagccagattgtgtcctccatcactgct
tccctgagatttgatggagccctgaatgttgacctgacagaattccagaccaacctggtg
ccctacccccgcatccacttccctctggccacatatgcccctgtcatctctgctgagaaa
gcctaccatgaacagctttctgtagcagagatcaccaatgcttgctttgagccagccaac
cagatggtgaaatgtgaccctcgccatggtaaatacatggcttgctgcctgttgtaccgt
ggtgacgtggttcccaaagatgtcaatgctgccattgccaccatcaaaaccaagcgcagc
atccagtttgtggattggtgccccactggcttcaaggttggcatcaactaccagcctccc
actgtggtgcctggtggagacctggccaaggtacagagagctgtgtgcatgctgagcaac
accacagccattgctgaggcctgggctcgcctggaccacaagtttgacctgatgtatgcc
aagcgtgcctttgttcactggtacgtgggtgaggggatggaggaaggcgagttttcagag
gcccgtgaagatatggctgcccttgagaaggattatgaggaggttggtgtggattctgtt
gaaggagagggtgaggaagaaggagaggaatactaa

KEGG   Homo sapiens (human): 84790
Entry
84790             CDS       T01001                                 

Gene name
TUBA1C, TUBA6, bcm948
Definition
(RefSeq) tubulin alpha 1c
  KO
K07374  tubulin alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04530  Tight junction
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    84790 (TUBA1C)
  09143 Cell growth and death
   04210 Apoptosis
    84790 (TUBA1C)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    84790 (TUBA1C)
   04540 Gap junction
    84790 (TUBA1C)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    84790 (TUBA1C)
   05012 Parkinson disease
    84790 (TUBA1C)
   05014 Amyotrophic lateral sclerosis
    84790 (TUBA1C)
   05016 Huntington disease
    84790 (TUBA1C)
   05020 Prion disease
    84790 (TUBA1C)
   05022 Pathways of neurodegeneration - multiple diseases
    84790 (TUBA1C)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    84790 (TUBA1C)
   05132 Salmonella infection
    84790 (TUBA1C)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    84790 (TUBA1C)
   03036 Chromosome and associated proteins [BR:hsa03036]
    84790 (TUBA1C)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    84790 (TUBA1C)
   04147 Exosome [BR:hsa04147]
    84790 (TUBA1C)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     84790 (TUBA1C)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     84790 (TUBA1C)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    84790 (TUBA1C)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   84790 (TUBA1C)
  Exosomal proteins of other body fluids (saliva and urine)
   84790 (TUBA1C)
  Exosomal proteins of colorectal cancer cells
   84790 (TUBA1C)
SSDB
Motif
Pfam: Tubulin Tubulin_C Tubulin_3
Other DBs
NCBI-GeneID: 84790
NCBI-ProteinID: NP_116093
HGNC: 20768
Ensembl: ENSG00000167553
Vega: OTTHUMG00000169497
Pharos: Q9BQE3(Tchem)
UniProt: Q9BQE3
LinkDB
Position
12q13.12
AA seq 449 aa
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGADSADGEDEGEEY
NT seq 1350 nt   +upstreamnt  +downstreamnt
atgcgtgagtgcatctccatccacgttggccaggctggtgtccagattggcaatgcctgc
tgggagctctactgcctggaacacggcatccagcccgatggccagatgccaagtgacaag
accattgggggaggagatgattccttcaacaccttcttcagtgaaacgggtgctggcaag
catgtgccccgggcagtgtttgtagacttggaacccacagtcattgatgaagttcgcact
ggcacttaccgccagctcttccaccctgagcaactcatcacaggcaaggaagatgctgcc
aataactatgcccgagggcactacaccattggcaaggagatcattgacctcgtgttggac
cgaattcgcaagctggctgaccagtgcaccggtcttcagggcttcttggttttccacagc
tttggtgggggaactggttctgggttcacctcgctgctcatggaacgtctctcagttgat
tatggcaagaagtccaagctggagttctccatttacccggcgccccaggtttccacagct
gtagttgagccctacaactccatcctcaccacccacaccaccctggagcactctgattgt
gccttcatggtagacaatgaggccatctatgacatctgtcgtagaaacctcgatatcgag
cgcccaacctacactaaccttaaccgccttattagccagattgtgtcctccatcactgct
tccctgagatttgatggagccctgaatgttgacctgacagaattccagaccaacctggtg
ccctacccccgcatccacttccctctggccacatatgcccctgtcatctctgctgagaaa
gcctaccacgaacagcttactgtagcagagatcaccaatgcttgctttgagccagccaac
cagatggtgaaatgtgaccctcgccatggtaaatacatggcttgctgcctgttataccgt
ggtgacgtggttcccaaagatgtcaatgctgccattgccaccatcaaaaccaagcgtacc
atccagtttgtggattggtgccccactggcttcaaggttggcattaattaccagcctccc
actgtggtgcctggcggagacctggccaaggtacagagagctgtgtgcatgctgagcaat
accacagctgttgccgaggcctgggctcgcctggaccacaagtttgacctgatgtatgcc
aagcgtgcctttgttcactggtacgtgggtgaggggatggaggaaggcgagttttcagag
gcccgtgaggacatggctgcccttgagaaggattatgaggaggttggagcagatagtgct
gacggagaggatgagggtgaagagtattaa

KEGG   Homo sapiens (human): 7278
Entry
7278              CDS       T01001                                 

Gene name
TUBA3C, TUBA2, bA408E5.3
Definition
(RefSeq) tubulin alpha 3c
  KO
K07374  tubulin alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04530  Tight junction
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7278 (TUBA3C)
  09143 Cell growth and death
   04210 Apoptosis
    7278 (TUBA3C)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    7278 (TUBA3C)
   04540 Gap junction
    7278 (TUBA3C)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7278 (TUBA3C)
   05012 Parkinson disease
    7278 (TUBA3C)
   05014 Amyotrophic lateral sclerosis
    7278 (TUBA3C)
   05016 Huntington disease
    7278 (TUBA3C)
   05020 Prion disease
    7278 (TUBA3C)
   05022 Pathways of neurodegeneration - multiple diseases
    7278 (TUBA3C)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    7278 (TUBA3C)
   05132 Salmonella infection
    7278 (TUBA3C)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    7278 (TUBA3C)
   03036 Chromosome and associated proteins [BR:hsa03036]
    7278 (TUBA3C)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7278 (TUBA3C)
   04147 Exosome [BR:hsa04147]
    7278 (TUBA3C)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     7278 (TUBA3C)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     7278 (TUBA3C)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    7278 (TUBA3C)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   7278 (TUBA3C)
  Exosomal proteins of other body fluids (saliva and urine)
   7278 (TUBA3C)
  Exosomal proteins of colorectal cancer cells
   7278 (TUBA3C)
SSDB
Motif
Pfam: Tubulin Tubulin_C Tubulin_3
Other DBs
NCBI-GeneID: 7278
NCBI-ProteinID: NP_005992
OMIM: 602528
HGNC: 12408
Ensembl: ENSG00000198033
Vega: OTTHUMG00000016481
Pharos: Q13748(Tchem)
UniProt: P0DPH7 P0DPH8 Q1ZYQ1
LinkDB
Position
13q12.11
AA seq 450 aa
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGVDSVEAEAEEGEEY
NT seq 1353 nt   +upstreamnt  +downstreamnt
atgcgtgagtgtatctctatccacgtggggcaggcaggagtccagatcggcaatgcctgc
tgggaactgtactgcctggaacatggaattcagcccgatggtcagatgccaagtgataaa
accattggtggtggggacgactccttcaacacgttcttcagtgagactggagctggcaag
cacgtgcccagagcagtgtttgtggacctggagcccactgtggtcgatgaagtgcgcaca
ggaacctataggcagctcttccacccagagcagctgatcaccgggaaggaagatgcggcc
aataattacgccagaggccattacaccatcggcaaggagatcgtcgacctggtcctggac
cggatccgcaaactggcggatctgtgcacgggactgcagggcttcctcatcttccacagt
tttgggggtggcactggctctgggttcgcatctctgctcatggagcggctctcagtggat
tacggcaagaagtccaagctagaatttgccatttacccagccccccaggtctccacggcc
gtggtggagccctacaactccatcctgaccacccacacgaccctggaacattctgactgt
gccttcatggtcgacaatgaagccatctatgacatatgtcggcgcaacctggacatcgag
cgtcccacgtacaccaacctcaatcgcctgattgggcagatcgtgtcctccatcacggcc
tccctgcgatttgacggggccctgaatgtggacttgacggaattccagaccaacctagtg
ccgtacccccgcatccacttccccctggccacctacgccccggtcatctcagccgagaag
gcctaccacgagcagctgtccgtggctgagatcaccaatgcctgcttcgagccagccaat
cagatggtcaagtgtgaccctcgccacggcaagtacatggcctgctgcatgttgtacagg
ggggatgtggtcccgaaagatgtcaacgcggccatcgccaccatcaagaccaagcgcacc
atccagtttgtagattggtgcccaactggatttaaggtgggcattaactaccagcccccc
acggtggtccctgggggagacctggccaaggtgcagcgggctgtgtgcatgctgagcaac
accacggccatcgcggaggcctgggctcgcctggaccataagttcgatctcatgtatgcc
aagcgggcctttgtgcactggtacgtgggagaaggcatggaggagggggagttctctgag
gcccgcgaggacctggcagctctggagaaggattatgaagaggtgggcgtggattccgtg
gaagccgaggctgaagaaggtgaagaatactga

KEGG   Homo sapiens (human): 113457
Entry
113457            CDS       T01001                                 

Gene name
TUBA3D, H2-ALPHA, KTCN9, TUBA2
Definition
(RefSeq) tubulin alpha 3d
  KO
K07374  tubulin alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04530  Tight junction
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    113457 (TUBA3D)
  09143 Cell growth and death
   04210 Apoptosis
    113457 (TUBA3D)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    113457 (TUBA3D)
   04540 Gap junction
    113457 (TUBA3D)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    113457 (TUBA3D)
   05012 Parkinson disease
    113457 (TUBA3D)
   05014 Amyotrophic lateral sclerosis
    113457 (TUBA3D)
   05016 Huntington disease
    113457 (TUBA3D)
   05020 Prion disease
    113457 (TUBA3D)
   05022 Pathways of neurodegeneration - multiple diseases
    113457 (TUBA3D)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    113457 (TUBA3D)
   05132 Salmonella infection
    113457 (TUBA3D)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    113457 (TUBA3D)
   03036 Chromosome and associated proteins [BR:hsa03036]
    113457 (TUBA3D)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    113457 (TUBA3D)
   04147 Exosome [BR:hsa04147]
    113457 (TUBA3D)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     113457 (TUBA3D)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     113457 (TUBA3D)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    113457 (TUBA3D)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   113457 (TUBA3D)
  Exosomal proteins of other body fluids (saliva and urine)
   113457 (TUBA3D)
  Exosomal proteins of colorectal cancer cells
   113457 (TUBA3D)
SSDB
Motif
Pfam: Tubulin Tubulin_C Tubulin_3
Other DBs
NCBI-GeneID: 113457
NCBI-ProteinID: NP_525125
OMIM: 617878
HGNC: 24071
Ensembl: ENSG00000075886
Vega: OTTHUMG00000153600
UniProt: P0DPH7 P0DPH8 Q1ZYQ1
LinkDB
Position
2q21.1
AA seq 450 aa
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGVDSVEAEAEEGEEY
NT seq 1353 nt   +upstreamnt  +downstreamnt
atgcgcgagtgtatctctatccacgtggggcaggcgggtgtccagatcggcaatgcctgc
tgggaactgtactgccttgaacatggaattcagcccgatggccaaatgccaagtgataaa
accattggtggcggggacgactccttcaacacgttcttcagtgagactggagctggcaag
cacgtgcccagagcagtgtttgtggacctggagcccactgtggtcgatgaagtgcgcaca
gggacctacaggcagctcttccacccggagcagctgatcaccgggaaggaagatgcagcc
aataattacgccaggggccattacaccatcggcaaggagattgttgacctagtcctggac
cggatccgcaaactggcggatctgtgcacaggactgcagggcttcctcatcttccacagc
tttgggggcggcactggctctgggttcgcatctctgctcatggagcggctctcagtggat
tacggcaagaagtccaagctagagtttgccatttacccagccccccaggtctccacagcc
gtggtggagccctacaactccatcctgaccacccacacgaccctggaacattctgactgt
gccttcatggtcgacaatgaagccatctatgacatatgtcggcgcaacctggacattgaa
cgtcccacgtacaccaacctcaatcgcctgattgggcagatcgtgtcctccatcacagcc
tccctgcgatttgatggggccctgaatgtggacttgacggaattccagaccaacctagtg
ccgtacccccgcatccacttccccctggccacctatgccccagtcatctcagctgagaag
gcctaccacgagcagctgtctgtggccgagatcaccaatgcctgcttcgagccagccaat
caaatggtcaagtgtgaccctcgccacggcaagtacatggcctgctgcatgttgtacagg
ggggacgtggtccccaaagacgtcaacgcggccatcgccaccatcaagaccaagcgcacc
atccagtttgtggattggtgcccgactggatttaaggtgggcattaactaccagcccccc
acagtggtccccgggggagacctggccaaggtgcagcgggccgtgtgcatgctgagcaac
accacggccattgcggaggcctgggcccgcctggaccataagttcgatctcatgtatgcc
aagcgggcctttgtgcactggtacgtgggcgaaggcatggaagagggagagttctctgag
gcccgcgaggacctggcagctctagagaaggattatgaagaggtgggcgtggattccgtg
gaagctgaggctgaagaaggcgaagaatactga

KEGG   Homo sapiens (human): 112714
Entry
112714            CDS       T01001                                 

Gene name
TUBA3E
Definition
(RefSeq) tubulin alpha 3e
  KO
K07374  tubulin alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04530  Tight junction
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    112714 (TUBA3E)
  09143 Cell growth and death
   04210 Apoptosis
    112714 (TUBA3E)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    112714 (TUBA3E)
   04540 Gap junction
    112714 (TUBA3E)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112714 (TUBA3E)
   05012 Parkinson disease
    112714 (TUBA3E)
   05014 Amyotrophic lateral sclerosis
    112714 (TUBA3E)
   05016 Huntington disease
    112714 (TUBA3E)
   05020 Prion disease
    112714 (TUBA3E)
   05022 Pathways of neurodegeneration - multiple diseases
    112714 (TUBA3E)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    112714 (TUBA3E)
   05132 Salmonella infection
    112714 (TUBA3E)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    112714 (TUBA3E)
   03036 Chromosome and associated proteins [BR:hsa03036]
    112714 (TUBA3E)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    112714 (TUBA3E)
   04147 Exosome [BR:hsa04147]
    112714 (TUBA3E)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     112714 (TUBA3E)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     112714 (TUBA3E)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    112714 (TUBA3E)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   112714 (TUBA3E)
  Exosomal proteins of other body fluids (saliva and urine)
   112714 (TUBA3E)
  Exosomal proteins of colorectal cancer cells
   112714 (TUBA3E)
SSDB
Motif
Pfam: Tubulin Tubulin_C Tubulin_3
Other DBs
NCBI-GeneID: 112714
NCBI-ProteinID: NP_997195
HGNC: 20765
Ensembl: ENSG00000152086
Vega: OTTHUMG00000131626
Pharos: Q6PEY2(Tchem)
UniProt: Q6PEY2
LinkDB
Position
2q21.1
AA seq 450 aa
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAASNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYSKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLVHKFDLMYAKWAFVHWYVGEGMEEGEFSE
AREDLAALEKDCEEVGVDSVEAEAEEGEAY
NT seq 1353 nt   +upstreamnt  +downstreamnt
atgcgcgagtgtatctctatccacgtggggcaggcgggtgtccagatcggcaatgcctgc
tgggaactgtactgccttgaacatggaattcagcccgatggtcaaatgccaagtgataaa
accattggtggcggggacgactccttcaacacgttcttcagtgagactggagctggcaag
cacgtgcccagagcagtgtttgtggacctggagcccactgtggtcgatgaagtgcgcaca
gggacctacaggcagctcttccacccagagcagctgatcaccgggaaggaagatgcagcc
agtaattacgccaggggccattacaccatcggcaaggagattgttgacctagtcctggac
cggatccgcaaactggcggatctgtgcacaggactgcagggcttcctcatcttccacagc
tttgggggcggcactggctctgggttcgcatctctgctcatggagcggctctcagtggat
tacagcaagaagtccaagctagagtttgccatttacccagccccccaggtctccacagcc
gtggtggagccctacaactccatcctaaccacccacacgaccctggaacattctgactgt
gccttcatggtcgacaatgaagccatctatgacatatgtcggcgcaacctggacattgaa
cgtcccacgtacaccaacctcaatcgcctgattgggcagatcgtgtcctccatcacggcc
tccctgcgatttgatggggccctgaatgtggacttgacggaattccagaccaacctcgtg
ccgtacccccgcatccacttccccctggccacctacgccccagtcatctcagctgagaag
gcctaccacgagcagctgtctgtggccgagatcaccaatgcctgcttcgagccagccaat
cagatggtcaagtgtgaccctcgccatggcaagtacatggcctgctgcatgttgtacagg
ggggacgtggtccccaaagacgtcaatgcggccatcgccaccatcaagaccaagcgcact
atccagtttgtggattggtgcccgactggatttaaggtgggcattaactaccagcccccc
acagtggtccccgggggagacctggccaaggtgcagcgggccgtgtgcatgctgagcaac
accacggccattgcggaggcctgggcccgcctggtccataagttcgatctcatgtatgcc
aagtgggcctttgtgcactggtacgtgggcgaaggcatggaagagggagagttctctgag
gcccgcgaggacctggcagctctagagaaggattgtgaagaggtgggcgtggattccgtg
gaagctgaggctgaagaaggcgaagcatactga

KEGG   Homo sapiens (human): 7277
Entry
7277              CDS       T01001                                 

Gene name
TUBA4A, ALS22, H2-ALPHA, TUBA1
Definition
(RefSeq) tubulin alpha 4a
  KO
K07374  tubulin alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04530  Tight junction
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7277 (TUBA4A)
  09143 Cell growth and death
   04210 Apoptosis
    7277 (TUBA4A)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    7277 (TUBA4A)
   04540 Gap junction
    7277 (TUBA4A)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7277 (TUBA4A)
   05012 Parkinson disease
    7277 (TUBA4A)
   05014 Amyotrophic lateral sclerosis
    7277 (TUBA4A)
   05016 Huntington disease
    7277 (TUBA4A)
   05020 Prion disease
    7277 (TUBA4A)
   05022 Pathways of neurodegeneration - multiple diseases
    7277 (TUBA4A)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    7277 (TUBA4A)
   05132 Salmonella infection
    7277 (TUBA4A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    7277 (TUBA4A)
   03036 Chromosome and associated proteins [BR:hsa03036]
    7277 (TUBA4A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7277 (TUBA4A)
   04147 Exosome [BR:hsa04147]
    7277 (TUBA4A)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     7277 (TUBA4A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     7277 (TUBA4A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    7277 (TUBA4A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   7277 (TUBA4A)
  Exosomal proteins of other body fluids (saliva and urine)
   7277 (TUBA4A)
  Exosomal proteins of colorectal cancer cells
   7277 (TUBA4A)
SSDB
Motif
Pfam: Tubulin Tubulin_C Tubulin_3
Other DBs
NCBI-GeneID: 7277
NCBI-ProteinID: NP_005991
OMIM: 191110
HGNC: 12407
Ensembl: ENSG00000127824
Vega: OTTHUMG00000133126
Pharos: P68366(Tchem)
UniProt: P68366
LinkDB
Position
2q35
AA seq 448 aa
MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGK
HVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLD
RIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGIDSYEDEDEGEE
NT seq 1347 nt   +upstreamnt  +downstreamnt
atgcgtgaatgcatctcagtccacgtggggcaggcaggtgtccagatgggcaatgcctgc
tgggagctctattgcttggaacatgggattcagcctgatgggcagatgcccagtgacaag
accattggtggaggggacgactccttcaccaccttcttctgtgaaactggtgctggaaaa
cacgtaccccgggcagtttttgtggatctggagcctacggtcattgatgagatccgaaat
ggcccataccgacagctcttccacccagagcagctcatcactgggaaagaggatgctgcc
aacaactatgcccgtggtcactataccattggcaaggagatcattgacccagtgctggat
cggatccgcaagctgtctgaccagtgcacaggacttcagggcttcctggtgttccacagc
tttggtgggggcactggctctggcttcacctcactcctgatggagcggctctctgttgac
tatggcaagaaatccaagctggaattctccatctacccagccccccaggtgtctacagcc
gtggtcgagccctacaactctatcctgaccacccacaccaccctggagcactcagactgt
gccttcatggtggacaacgaagcaatctatgacatctgccgccgcaacctagacatcgag
cgcccaacctacaccaacctcaatcgcctcattagccaaattgtctcctccatcacagct
tctctgcgctttgacggggccctcaatgtggacctgacagagttccagaccaacctggtg
ccctaccctcgcatccacttccccctggccacctatgcaccagtcatctctgcagaaaag
gcataccacgagcagctgtcggtggcagagatcaccaatgcctgctttgagcctgccaac
cagatggtaaagtgtgatccccggcacggcaagtacatggcctgctgcctgctgtaccgt
ggagatgtggtgcccaaggatgtcaacgctgccattgccgccatcaagaccaagcgcagc
attcagtttgtggactggtgccccacaggcttcaaggttggtatcaactaccagcctccc
actgtggtgcctgggggtgacctggccaaggtgcagcgtgccgtgtgcatgctgagcaac
acgaccgccatcgccgaggcctgggcccgcctggaccacaagttcgacctgatgtatgcc
aagagggcgtttgtgcactggtatgtgggtgagggcatggaggagggtgagttctccgag
gcccgtgaggatatggctgccctggagaaggattatgaggaggtgggcatcgactcctat
gaggacgaggatgagggagaagaataa

KEGG   Homo sapiens (human): 51807
Entry
51807             CDS       T01001                                 

Gene name
TUBA8, CDCBM8, TUBAL2
Definition
(RefSeq) tubulin alpha 8
  KO
K07374  tubulin alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04530  Tight junction
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H01881  Complex cortical dysplasia with other brain malformations
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    51807 (TUBA8)
  09143 Cell growth and death
   04210 Apoptosis
    51807 (TUBA8)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    51807 (TUBA8)
   04540 Gap junction
    51807 (TUBA8)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    51807 (TUBA8)
   05012 Parkinson disease
    51807 (TUBA8)
   05014 Amyotrophic lateral sclerosis
    51807 (TUBA8)
   05016 Huntington disease
    51807 (TUBA8)
   05020 Prion disease
    51807 (TUBA8)
   05022 Pathways of neurodegeneration - multiple diseases
    51807 (TUBA8)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    51807 (TUBA8)
   05132 Salmonella infection
    51807 (TUBA8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    51807 (TUBA8)
   03036 Chromosome and associated proteins [BR:hsa03036]
    51807 (TUBA8)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    51807 (TUBA8)
   04147 Exosome [BR:hsa04147]
    51807 (TUBA8)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     51807 (TUBA8)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     51807 (TUBA8)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    51807 (TUBA8)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   51807 (TUBA8)
  Exosomal proteins of other body fluids (saliva and urine)
   51807 (TUBA8)
  Exosomal proteins of colorectal cancer cells
   51807 (TUBA8)
SSDB
Motif
Pfam: Tubulin Tubulin_C Tubulin_3
Other DBs
NCBI-GeneID: 51807
NCBI-ProteinID: NP_061816
OMIM: 605742
HGNC: 12410
Ensembl: ENSG00000183785
Vega: OTTHUMG00000150097
Pharos: Q9NY65(Tbio)
UniProt: Q9NY65
LinkDB
Position
22q11.21
AA seq 449 aa
MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGK
HVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLD
RIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNS
QMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGTDSFEEENEGEEF
NT seq 1350 nt   +upstreamnt  +downstreamnt
atgcgggaatgcatatcagtccacgtgggccaagcgggagttcagattggcaatgcctgc
tgggagctcttctgcctggaacacggcatccaggcagacggcacttttgatgctcaagct
agcaagatcaacgatgatgactccttcaccacctttttcagcgagactggcaatgggaag
catgtgccccgggccgtcatgatagatctggagcctactgtagtggatgaggttcgggca
ggaacctaccgccagctcttccatccagagcagctgatcacaggaaaggaggatgcagcc
aacaactatgcccggggccactacacggtgggcaaggagagcattgacctggtgctggac
cgcatacggaagctgacagatgcttgctctggcctgcagggcttcctgattttccacagt
tttggtgggggcactggctccggcttcacttctctgctgatggaacgcctctccctggat
tatggcaagaaatccaagctggagtttgccatctacccagccccccaggtctctactgca
gtggtggagccctacaactccatcctgaccacccacaccacactggaacattcagattgt
gctttcatggtggacaacgaagccatctatgacatctgccgcaggaaccttgacattgag
cgccctacctataccaacctcaaccgcctcatcagtcagattgtgtcctcaatcactgct
tctctccgctttgacggggccctcaatgtggacctcactgagttccagaccaacctggtg
ccctacccccgcatccacttcccgctggtcacctacgcgcccatcatctctgccgagaaa
gcctatcacgaacagctctctgtggccgagataaccagctcctgctttgagcccaacagc
cagatggtgaagtgcgacccgagacatggcaagtacatggcctgctgcatgctctaccgg
ggcgacgtggtgcccaaggatgtgaatgtcgctattgctgccatcaagaccaagaggacc
atccagtttgtagactggtgtcccacaggcttcaaggtgggcatcaactaccagcccccg
accgtggtccccgggggagacctggccaaggtgcagcgggccgtctgcatgctcagcaac
accacggccattgcggaggcctgggcccgcctcgaccacaagttcgacctcatgtacgcc
aagcgggcctttgtgcattggtatgtgggagaggggatggaagaaggagaattttctgag
gccagggaagacttagctgccctggagaaggattatgaagaagtggggactgattcgttt
gaagaagaaaatgaaggggaggaattttaa

KEGG   Homo sapiens (human): 203068
Entry
203068            CDS       T01001                                 

Gene name
TUBB, CDCBM6, CSCSC1, M40, OK/SW-cl.56, TUBB1, TUBB5
Definition
(RefSeq) tubulin beta class I
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H01579  Congenital symmetric circumferential skin creases
H01881  Complex cortical dysplasia with other brain malformations
Drug target
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529<US>
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980<JP/US>
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    203068 (TUBB)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    203068 (TUBB)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    203068 (TUBB)
   05012 Parkinson disease
    203068 (TUBB)
   05014 Amyotrophic lateral sclerosis
    203068 (TUBB)
   05016 Huntington disease
    203068 (TUBB)
   05020 Prion disease
    203068 (TUBB)
   05022 Pathways of neurodegeneration - multiple diseases
    203068 (TUBB)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    203068 (TUBB)
   05132 Salmonella infection
    203068 (TUBB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    203068 (TUBB)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    203068 (TUBB)
   04147 Exosome [BR:hsa04147]
    203068 (TUBB)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     203068 (TUBB)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    203068 (TUBB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   203068 (TUBB)
  Exosomal proteins of colorectal cancer cells
   203068 (TUBB)
  Exosomal proteins of bladder cancer cells
   203068 (TUBB)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 203068
NCBI-ProteinID: NP_821133
OMIM: 191130
HGNC: 20778
Ensembl: ENSG00000196230
Vega: OTTHUMG00000031059
Pharos: P07437(Tclin)
UniProt: P07437 Q5SU16
LinkDB
Structure
PDB: 
6I2I 5N5N

Position
6p21.33
AA seq 444 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgagggaaatcgtgcacatccaggctggtcagtgtggcaaccagatcggtgccaagttc
tgggaggtgatcagtgatgaacatggcatcgaccccaccggcacctaccacggggacagc
gacctgcagctggaccgcatctctgtgtactacaatgaagccacaggtggcaaatatgtt
cctcgtgccatcctggtggatctagaacctgggaccatggactctgttcgctcaggtcct
tttggccagatctttagaccagacaactttgtatttggtcagtctggggcaggtaacaac
tgggccaaaggccactacacagagggcgccgagctggttgattctgtcctggatgtggta
cggaaggaggcagagagctgtgactgcctgcagggcttccagctgacccactcactgggc
gggggcacaggctctggaatgggcactctccttatcagcaagatccgagaagaataccct
gatcgcatcatgaataccttcagtgtggtgccttcacccaaagtgtctgacaccgtggtc
gagccctacaatgccaccctctccgtccatcagttggtagagaatactgatgagacctat
tgcattgacaacgaggccctctatgatatctgcttccgcactctgaagctgaccacacca
acctacggggatctgaaccaccttgtctcagccaccatgagtggtgtcaccacctgcctc
cgtttccctggccagctcaatgctgacctccgcaagttggcagtcaacatggtccccttc
ccacgtctccatttctttatgcctggctttgcccctctcaccagccgtggaagccagcag
tatcgagctctcacagtgccggaactcacccagcaggtcttcgatgccaagaacatgatg
gctgcctgtgacccccgccacggccgatacctcaccgtggctgctgtcttccgtggtcgg
atgtccatgaaggaggtcgatgagcagatgcttaacgtgcagaacaagaacagcagctac
tttgtggaatggatccccaacaatgtcaagacagccgtctgtgacatcccacctcgtggc
ctcaagatggcagtcaccttcattggcaatagcacagccatccaggagctcttcaagcgc
atctcggagcagttcactgccatgttccgccggaaggccttcctccactggtacacaggc
gagggcatggacgagatggagttcaccgaggctgagagcaacatgaacgacctcgtctct
gagtatcagcagtaccaggatgccaccgcagaagaggaggaggatttcggtgaggaggcc
gaagaggaggcctaa

KEGG   Homo sapiens (human): 81027
Entry
81027             CDS       T01001                                 

Gene name
TUBB1
Definition
(RefSeq) tubulin beta 1 class VI
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H01740  Macrothrombocytopenia
Drug target
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529<US>
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980<JP/US>
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    81027 (TUBB1)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    81027 (TUBB1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    81027 (TUBB1)
   05012 Parkinson disease
    81027 (TUBB1)
   05014 Amyotrophic lateral sclerosis
    81027 (TUBB1)
   05016 Huntington disease
    81027 (TUBB1)
   05020 Prion disease
    81027 (TUBB1)
   05022 Pathways of neurodegeneration - multiple diseases
    81027 (TUBB1)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    81027 (TUBB1)
   05132 Salmonella infection
    81027 (TUBB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    81027 (TUBB1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    81027 (TUBB1)
   04147 Exosome [BR:hsa04147]
    81027 (TUBB1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     81027 (TUBB1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    81027 (TUBB1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   81027 (TUBB1)
  Exosomal proteins of colorectal cancer cells
   81027 (TUBB1)
  Exosomal proteins of bladder cancer cells
   81027 (TUBB1)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_2 Tubulin_3
Other DBs
NCBI-GeneID: 81027
NCBI-ProteinID: NP_110400
OMIM: 612901
HGNC: 16257
Ensembl: ENSG00000101162
Vega: OTTHUMG00000032860
Pharos: Q9H4B7(Tclin)
UniProt: Q9H4B7
LinkDB
Position
20q13.32
AA seq 451 aa
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYV
PRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVV
RHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVV
EPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTM
AACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRG
LSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS
EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
NT seq 1356 nt   +upstreamnt  +downstreamnt
atgcgtgaaattgtccatattcagattggccagtgtggcaaccagatcggagccaagttc
tgggagatgattggtgaggaacacgggatcgacttggctgggagcgaccgcggggcctcg
gccttgcagctggagagaatcagcgtgtactacaacgaagcctacggtaggaaatatgtg
ccccgagcagtcttggtggacctagaacctgggacgatggacagcattcgatctagcaaa
ttaggagctctctttcaacccgacagttttgtccatggtaactctggggctggcaacaac
tgggccaaaggccactacacggagggagccgagctgatcgagaatgtcctagaggtggtg
aggcacgagagtgagagctgtgactgcctgcagggcttccagatcgtccactccctgggc
gggggcacaggctccgggatgggcactctgctcatgaacaagattagagaggagtacccg
gaccggatcatgaattccttcagcgtcatgccttctcccaaggtgtcggacactgtggtg
gagccctacaacgcggttctgtctatccaccagctgattgagaatgcagatgcctgtttc
tgcattgacaatgaggccctctatgacatctgcttccgtaccctgaagctgacgacaccc
acctatggggatctcaaccacctagtgtccttgaccatgagcggcataaccacctccctc
cggttcccgggtcagctcaacgcagacctgcgcaagctggcggtgaacatggtccccttc
ccccgcctgcacttctttatgcccggctttgccccactcacggcccagggcagccagcag
taccgagccctctccgtggccgagctcacccagcagatgttcgatgcccgcaataccatg
gctgcctgtgacctccgccgtggccgctacctcacagtggcctgcattttccggggcaag
atgtccaccaaggaagtggaccagcaactgctctccgtgcagaccaggaacagcagctgc
tttgtggagtggattcccaacaacgtcaaggtggctgtctgcgacatcccgccccggggg
ctgagcatggccgccaccttcattggcaacaacacggccatccaagagatctttaatagg
gtctctgagcatttctcagccatgttcaaaaggaaagcttttgtgcactggtacaccagc
gaagggatggacataaacgaatttggggaagctgaaaataacatccatgatttggtatcc
gagtaccaacaatttcaagatgccaaagcagttctagaggaagatgaagaggtcacggag
gaggcagaaatggagccagaagataagggacattaa

KEGG   Homo sapiens (human): 7280
Entry
7280              CDS       T01001                                 

Gene name
TUBB2A, CDCBM5, TUBB, TUBB2
Definition
(RefSeq) tubulin beta 2A class IIa
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H01881  Complex cortical dysplasia with other brain malformations
Drug target
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529<US>
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980<JP/US>
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7280 (TUBB2A)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    7280 (TUBB2A)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7280 (TUBB2A)
   05012 Parkinson disease
    7280 (TUBB2A)
   05014 Amyotrophic lateral sclerosis
    7280 (TUBB2A)
   05016 Huntington disease
    7280 (TUBB2A)
   05020 Prion disease
    7280 (TUBB2A)
   05022 Pathways of neurodegeneration - multiple diseases
    7280 (TUBB2A)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    7280 (TUBB2A)
   05132 Salmonella infection
    7280 (TUBB2A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    7280 (TUBB2A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7280 (TUBB2A)
   04147 Exosome [BR:hsa04147]
    7280 (TUBB2A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     7280 (TUBB2A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    7280 (TUBB2A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   7280 (TUBB2A)
  Exosomal proteins of colorectal cancer cells
   7280 (TUBB2A)
  Exosomal proteins of bladder cancer cells
   7280 (TUBB2A)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 7280
NCBI-ProteinID: NP_001060
OMIM: 615101
HGNC: 12412
Ensembl: ENSG00000137267
Vega: OTTHUMG00000014135
Pharos: Q13885(Tclin)
UniProt: Q13885
LinkDB
Position
6p25.2
AA seq 445 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
NT seq 1338 nt   +upstreamnt  +downstreamnt
atgcgcgagatcgtgcacatccaggcgggccagtgcggcaaccagatcggcgccaagttt
tgggaggtcatcagcgatgagcatgggatcgaccccacaggcagttaccatggagacagt
gacttgcagctggagagaatcaacgtgtactacaatgaggctgctggtaacaaatatgta
cctcgggccatcctggtggatctggagcctggcaccatggactctgtcaggtctggaccc
ttcggccagatcttcagaccagacaacttcgtgttcggccagagtggagccgggaataac
tgggccaagggccactacacagagggagccgagctggtcgactcggtcctggatgtggtg
aggaaggagtcagagagctgtgactgtctccagggcttccagctgacccactctctgggg
ggcggcacggggtccgggatgggcaccctgctcatcagcaagatccgggaagagtaccca
gaccgcatcatgaacaccttcagcgtcatgccctcacccaaggtgtcagacacggtggtg
gagccctacaacgccaccctctctgtccaccagctggtggaaaacacagatgaaacctac
tccattgataacgaggccctgtatgacatctgcttccgcaccctgaagctgaccaccccc
acctacggggacctcaaccacctggtgtcggccaccatgagcggggtcaccacctgcctg
cgcttcccgggccagctgaacgcagacctgcgcaagctggcggtgaacatggtgcccttc
cctcgcctgcacttcttcatgcccggcttcgcgcccctgaccagccggggcagccagcag
taccgggcgctcacggtgcccgagctcacccagcagatgttcgactccaagaacatgatg
gccgcctgcgacccgcgccacggccgctacctgacggtggctgccatcttccggggccgc
atgtccatgaaggaggtggacgagcagatgctcaacgtgcagaacaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaagacggccgtgtgcgacatcccgccccgcggc
ctgaagatgtcggccaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaacgacctggtgtcc
gagtaccagcagtaccaggacgccacggccgacgaacaaggggagttcgaggaggaggag
ggcgaggacgaggcttaa

KEGG   Homo sapiens (human): 347733
Entry
347733            CDS       T01001                                 

Gene name
TUBB2B, CDCBM7, PMGYSA, bA506K6.1
Definition
(RefSeq) tubulin beta 2B class IIb
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H01881  Complex cortical dysplasia with other brain malformations
Drug target
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529<US>
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980<JP/US>
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    347733 (TUBB2B)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    347733 (TUBB2B)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    347733 (TUBB2B)
   05012 Parkinson disease
    347733 (TUBB2B)
   05014 Amyotrophic lateral sclerosis
    347733 (TUBB2B)
   05016 Huntington disease
    347733 (TUBB2B)
   05020 Prion disease
    347733 (TUBB2B)
   05022 Pathways of neurodegeneration - multiple diseases
    347733 (TUBB2B)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    347733 (TUBB2B)
   05132 Salmonella infection
    347733 (TUBB2B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    347733 (TUBB2B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    347733 (TUBB2B)
   04147 Exosome [BR:hsa04147]
    347733 (TUBB2B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     347733 (TUBB2B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    347733 (TUBB2B)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   347733 (TUBB2B)
  Exosomal proteins of colorectal cancer cells
   347733 (TUBB2B)
  Exosomal proteins of bladder cancer cells
   347733 (TUBB2B)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 347733
NCBI-ProteinID: NP_821080
OMIM: 612850
HGNC: 30829
Ensembl: ENSG00000137285
Vega: OTTHUMG00000014143
Pharos: Q9BVA1(Tclin)
UniProt: Q9BVA1 A0A384MEE3
LinkDB
Structure
PDB: 
6E7C

Position
6p25.2
AA seq 445 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
NT seq 1338 nt   +upstreamnt  +downstreamnt
atgcgtgagatcgtgcacatccaggcgggccagtgcggcaaccagatcggcgccaagttt
tgggaggtcatcagtgatgagcatgggattgaccccactggcagttaccatggagacagt
gatttgcagctggagagaatcaatgtttactacaatgaagccactggtaacaaatatgtt
cctcgggccatcctcgtggatctggagccaggcacgatggattcggttaggtctggacca
ttcggccagatcttcagaccagacaatttcgtgtttggccagagtggagccgggaataac
tgggccaagggccactacacagagggagccgagctggtcgactcggtcctggatgtggtg
aggaaggagtcagagagctgtgactgtctccagggcttccagctgacccactctctgggg
ggcggcacggggtccgggatgggcaccctgctcatcagcaagatccgggaagagtaccca
gaccgcatcatgaacaccttcagcgtcatgccctcacccaaggtgtcagacacggtggtg
gagccctacaacgccaccctctcggtccaccagctggtggaaaacacagatgaaacctac
tgcattgacaacgaggccctgtatgacatctgcttccgcaccctgaagctgaccaccccc
acctacggggacctcaaccacctggtgtcggccaccatgagcggggtcaccacctgcctg
cgcttcccgggccagctgaacgcagacctgcgcaagctggcggtgaacatggtgcccttc
cctcgcctgcacttcttcatgcccggcttcgcgcccctgaccagccggggcagccagcag
taccgggcgctcacggtgcccgagctcacccagcagatgttcgactccaagaacatgatg
gccgcctgcgacccgcgccacggccgctacctgacggtggctgccatcttccggggccgc
atgtccatgaaggaggtggacgagcagatgctcaacgtgcagaacaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaagacggccgtgtgcgacatcccgccccgcggc
ctgaagatgtcggccaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaacgacctggtgtcc
gagtaccagcagtaccaggacgccacggccgacgaacaaggggagttcgaggaggaggag
ggcgaggacgaggcgtag

KEGG   Homo sapiens (human): 10381
Entry
10381             CDS       T01001                                 

Gene name
TUBB3, CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, beta-4
Definition
(RefSeq) tubulin beta 3 class III
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H00838  Congenital fibrosis of the extraocular muscles
H01881  Complex cortical dysplasia with other brain malformations
Drug target
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529<US>
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980<JP/US>
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    10381 (TUBB3)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    10381 (TUBB3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10381 (TUBB3)
   05012 Parkinson disease
    10381 (TUBB3)
   05014 Amyotrophic lateral sclerosis
    10381 (TUBB3)
   05016 Huntington disease
    10381 (TUBB3)
   05020 Prion disease
    10381 (TUBB3)
   05022 Pathways of neurodegeneration - multiple diseases
    10381 (TUBB3)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10381 (TUBB3)
   05132 Salmonella infection
    10381 (TUBB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10381 (TUBB3)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10381 (TUBB3)
   04147 Exosome [BR:hsa04147]
    10381 (TUBB3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     10381 (TUBB3)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    10381 (TUBB3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10381 (TUBB3)
  Exosomal proteins of colorectal cancer cells
   10381 (TUBB3)
  Exosomal proteins of bladder cancer cells
   10381 (TUBB3)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 10381
NCBI-ProteinID: NP_006077
OMIM: 602661
HGNC: 20772
Ensembl: ENSG00000258947
Vega: OTTHUMG00000138985
Pharos: Q13509(Tclin)
UniProt: Q13509 Q53G92
LinkDB
Structure
PDB: 
6E7B 5IJ9 5IJ0 5JCO

Position
16q24.3
AA seq 450 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPK
NT seq 1353 nt   +upstreamnt  +downstreamnt
atgagggagatcgtgcacatccaggccggccagtgcggcaaccagatcggggccaagttc
tgggaagtcatcagtgatgagcatggcatcgaccccagcggcaactacgtgggcgactcg
gacttgcagctggagcggatcagcgtctactacaacgaggcctcttctcacaagtacgtg
cctcgagccattctggtggacctggaacccggaaccatggacagtgtccgctcaggggcc
tttggacatctcttcaggcctgacaatttcatctttggtcagagtggggccggcaacaac
tgggccaagggtcactacacggagggggcggagctggtggattcggtcctggatgtggtg
cggaaggagtgtgaaaactgcgactgcctgcagggcttccagctgacccactcgctgggg
ggcggcacgggctccggcatgggcacgttgctcatcagcaaggtgcgtgaggagtatccc
gaccgcatcatgaacaccttcagcgtcgtgccctcacccaaggtgtcagacacggtggtg
gagccctacaacgccacgctgtccatccaccagctggtggagaacacggatgagacctac
tgcatcgacaacgaggcgctctacgacatctgcttccgcaccctcaagctggccacgccc
acctacggggacctcaaccacctggtatcggccaccatgagcggagtcaccacctccttg
cgcttcccgggccagctcaacgctgacctgcgcaagctggccgtcaacatggtgcccttc
ccgcgcctgcacttcttcatgcccggcttcgcccccctcacagcccggggcagccagcag
taccgggccctgaccgtgcccgagctcacccagcagatgttcgatgccaagaacatgatg
gccgcctgcgacccgcgccacggccgctacctgacggtggccaccgtgttccggggccgc
atgtccatgaaggaggtggacgagcagatgctggccatccagagcaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaaggtggccgtgtgtgacatcccgccccgcggc
ctcaagatgtcctccaccttcatcgggaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaacgacctggtgtcc
gagtaccagcagtaccaggacgccacggccgaggaagagggcgagatgtacgaagacgac
gaggaggagtcggaggcccagggccccaagtga

KEGG   Homo sapiens (human): 10382
Entry
10382             CDS       T01001                                 

Gene name
TUBB4A, DYT4, TUBB4, beta-5
Definition
(RefSeq) tubulin beta 4A class IVa
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H00679  Hypomyelinating leukodystrophy
Drug target
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529<US>
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980<JP/US>
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    10382 (TUBB4A)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    10382 (TUBB4A)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10382 (TUBB4A)
   05012 Parkinson disease
    10382 (TUBB4A)
   05014 Amyotrophic lateral sclerosis
    10382 (TUBB4A)
   05016 Huntington disease
    10382 (TUBB4A)
   05020 Prion disease
    10382 (TUBB4A)
   05022 Pathways of neurodegeneration - multiple diseases
    10382 (TUBB4A)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10382 (TUBB4A)
   05132 Salmonella infection
    10382 (TUBB4A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10382 (TUBB4A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10382 (TUBB4A)
   04147 Exosome [BR:hsa04147]
    10382 (TUBB4A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     10382 (TUBB4A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    10382 (TUBB4A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10382 (TUBB4A)
  Exosomal proteins of colorectal cancer cells
   10382 (TUBB4A)
  Exosomal proteins of bladder cancer cells
   10382 (TUBB4A)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 10382
NCBI-ProteinID: NP_001276058
OMIM: 602662
HGNC: 20774
Ensembl: ENSG00000104833
Vega: OTTHUMG00000181829
Pharos: P04350(Tclin)
UniProt: P04350
LinkDB
Position
19p13.3
AA seq 444 aa
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEGEFEEEAEEEVA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgcgggagatcgtgcacctgcaggccggccagtgcggcaaccagatcggggccaagttt
tgggaggttatcagtgacgaacatggcatcgaccccacaggcacataccatggggacagt
gacctgcaactggagaggatcaacgtgtactacaacgaggccacaggaggaaattatgtc
cccagagcggtgctggtggacctggaacccggcaccatggactctgtccgttctggcccc
ttcggtcagatctttcggccggacaacttcgtgtttggccaatccggagccggcaacaac
tgggcaaaggggcactacacggagggcgcagagctggtggacgctgtcctggacgtagtc
cggaaggaggccgagagctgcgactgccttcagggcttccagctgacccactcgctgggg
ggtggcacggggtccggaatgggcacgctgctcatcagtaagatccgcgaggagttccca
gaccgcatcatgaacaccttcagcgtggtgccctcgcccaaagtgtcagacacggtggtg
gagccctacaacgccacgctgtctgtgcaccagctggtggagaatacggatgagacctac
tgcatcgacaacgaggcactctacgacatctgtttccgcaccctcaagctgaccaccccc
acctacggggacctcaaccacctggtgtcggccaccatgagcggggtcaccacctgcctg
cgcttcccgggccagctgaacgccgacctgcgcaagctggccgtcaacatggttcccttt
cctcgcctgcacttcttcatgcccggcttcgcacccctgaccagccggggcagccagcag
taccgggccctgacggtgcccgagctcacccagcagatgttcgatgccaagaacatgatg
gcggcgtgcgacccgcgccacggccgctacctgaccgtggccgccgtgttccggggccgc
atgtccatgaaggaggtggacgagcagatgctgagcgtgcagagcaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaagacggccgtgtgcgacatcccgccccgcggc
ctgaagatggccgcgaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcttgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaatgacctggtatct
gagtaccagcagtaccaggacgccacggccgaggagggcgagttcgaggaggaggcggag
gaggaggtggcctag

KEGG   Homo sapiens (human): 10383
Entry
10383             CDS       T01001                                 

Gene name
TUBB4B, Beta2, LCAEOD, TUBB2, TUBB2C
Definition
(RefSeq) tubulin beta 4B class IVb
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Drug target
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529<US>
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980<JP/US>
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    10383 (TUBB4B)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    10383 (TUBB4B)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10383 (TUBB4B)
   05012 Parkinson disease
    10383 (TUBB4B)
   05014 Amyotrophic lateral sclerosis
    10383 (TUBB4B)
   05016 Huntington disease
    10383 (TUBB4B)
   05020 Prion disease
    10383 (TUBB4B)
   05022 Pathways of neurodegeneration - multiple diseases
    10383 (TUBB4B)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10383 (TUBB4B)
   05132 Salmonella infection
    10383 (TUBB4B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10383 (TUBB4B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10383 (TUBB4B)
   04147 Exosome [BR:hsa04147]
    10383 (TUBB4B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     10383 (TUBB4B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    10383 (TUBB4B)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10383 (TUBB4B)
  Exosomal proteins of colorectal cancer cells
   10383 (TUBB4B)
  Exosomal proteins of bladder cancer cells
   10383 (TUBB4B)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 10383
NCBI-ProteinID: NP_006079
OMIM: 602660
HGNC: 20771
Ensembl: ENSG00000188229
Vega: OTTHUMG00000131783
Pharos: P68371(Tclin)
UniProt: P68371
LinkDB
Position
9q34.3
AA seq 445 aa
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA
NT seq 1338 nt   +upstreamnt  +downstreamnt
atgagggaaatcgtgcacttgcaggccgggcagtgcggcaaccaaatcggcgccaagttt
tgggaggtgatcagcgatgagcacggcatcgaccccacgggcacctaccacggggacagc
gacctgcagctggaacgcatcaacgtgtactacaatgaggccaccggcggcaagtacgtg
ccccgcgccgtgctcgtggatctggagcccggcaccatggactccgtgcgctcggggccc
ttcgggcagatcttccggccggacaacttcgttttcggtcagagtggtgctgggaacaac
tgggccaaggggcactacacagaaggcgcggagctggtggactcggtgctggatgttgtg
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtaccctcctcatcagcaagatccgggaggagtaccca
gacaggatcatgaacacgtttagtgtggtgccttcgcccaaagtgtcagacacagtggtg
gagccctacaacgccaccctctcagtccaccagctcgtagaaaacacagacgagacctac
tgcattgataacgaagctctctacgacatttgcttcagaaccctaaagctgaccacgccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacctgcctg
cgcttcccaggccagctcaatgctgacctgcggaagctggctgtgaacatggtcccgttt
ccccggctgcacttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggcgctgaccgtgcccgagctcacccagcagatgtttgatgccaagaacatgatg
gctgcctgcgacccccgccatggccgctacctgacggttgccgccgtgttcaggggccgc
atgtccatgaaggaggtggatgagcaaatgcttaatgtccaaaacaaaaacagcagctat
tttgttgagtggatccccaacaatgtgaaaacggctgtctgtgacatcccacctcggggg
ctaaaaatgtccgccaccttcattggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaatgacctggtgtcc
gagtaccagcagtaccaggatgccacagccgaggaggagggcgagttcgaggaggaggct
gaggaggaggtggcctag

KEGG   Homo sapiens (human): 84617
Entry
84617             CDS       T01001                                 

Gene name
TUBB6, FPVEPD, HsT1601, TUBB-5
Definition
(RefSeq) tubulin beta 6 class V
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Drug target
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529<US>
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980<JP/US>
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    84617 (TUBB6)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    84617 (TUBB6)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    84617 (TUBB6)
   05012 Parkinson disease
    84617 (TUBB6)
   05014 Amyotrophic lateral sclerosis
    84617 (TUBB6)
   05016 Huntington disease
    84617 (TUBB6)
   05020 Prion disease
    84617 (TUBB6)
   05022 Pathways of neurodegeneration - multiple diseases
    84617 (TUBB6)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    84617 (TUBB6)
   05132 Salmonella infection
    84617 (TUBB6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    84617 (TUBB6)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    84617 (TUBB6)
   04147 Exosome [BR:hsa04147]
    84617 (TUBB6)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     84617 (TUBB6)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    84617 (TUBB6)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   84617 (TUBB6)
  Exosomal proteins of colorectal cancer cells
   84617 (TUBB6)
  Exosomal proteins of bladder cancer cells
   84617 (TUBB6)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 84617
NCBI-ProteinID: NP_001290453
OMIM: 615103
HGNC: 20776
Ensembl: ENSG00000176014
Vega: OTTHUMG00000131692
Pharos: Q9BUF5(Tclin)
UniProt: Q9BUF5
LinkDB
Position
18p11.21
AA seq 446 aa
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYV
PRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVV
RKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDARNMM
AACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATANDGEEAFEDEEEEIDG
NT seq 1341 nt   +upstreamnt  +downstreamnt
atgagggagatcgtgcacatccaggcgggccagtgcgggaaccagatcggcaccaagttt
tgggaagtgatcagcgatgagcacggcatcgacccggccggaggctacgtgggagactcg
gcgctgcagctggagagaatcaacgtctactacaatgagtcatcgtctcagaaatatgtg
cccagggccgccctggtggacttagagccaggcaccatggacagcgtgcggtctgggcct
tttgggcagcttttccggcctgacaacttcatctttggccagacgggtgcagggaacaac
tgggcgaaagggcactacacggagggcgcggagctggtggacgcagtgctggacgtggtg
cggaaggagtgcgagcactgcgactgcctgcagggcttccagctcacgcactcgctgggc
ggcggcacgggctcaggcatgggcacgctgctcatcagcaagatccgtgaggagttcccg
gaccgcatcatgaacaccttcagcgtcatgccctcgcccaaggtgtcggacacggtggtg
gagccctacaatgccacactgtcggtgcaccagctggtggagaatacagacgagacctac
tgcatcgacaacgaggcgctctatgacatctgcttccgcactctgaagctgacaacgccc
acctacggggacctcaaccacctggtgtccgccaccatgagtggggtcaccacctcgctg
cgcttcccgggccagctcaatgctgacctgcgcaagctggcggtgaacatggtgcccttc
ccgcgcctgcacttcttcatgcctggcttcgcgccgctcaccagccgcggcagccagcag
taccgggccctgaccgtgcccgagctcacccagcagatgttcgacgccaggaacatgatg
gccgcctgcgatccgcgccatggccgctacctgaccgtggccaccgtgttccgcgggccc
atgtccatgaaggaggtggacgagcagatgctggccatccagagtaagaacagcagctac
ttcgtggagtggattcccaacaacgtgaaggtggccgtgtgcgacatcccgccccgcggc
ctgaagatggcctccaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttctcagccatgttccggcgcaaggccttcctgcactggttcacgggt
gagggcatggatgaaatggagttcaccgaggcggagagcaacatgaacgacctggtatcc
gagtaccagcagtaccaggatgccaccgccaatgacggggaggaagcttttgaggatgag
gaagaggagatcgatggatag

KEGG   Homo sapiens (human): 347688
Entry
347688            CDS       T01001                                 

Gene name
TUBB8, OOMD, OOMD2, bA631M21.2
Definition
(RefSeq) tubulin beta 8 class VIII
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Disease
H01897  Oocyte maturation defect
Drug target
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529<US>
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980<JP/US>
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    347688 (TUBB8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    347688 (TUBB8)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    347688 (TUBB8)
   05012 Parkinson disease
    347688 (TUBB8)
   05014 Amyotrophic lateral sclerosis
    347688 (TUBB8)
   05016 Huntington disease
    347688 (TUBB8)
   05020 Prion disease
    347688 (TUBB8)
   05022 Pathways of neurodegeneration - multiple diseases
    347688 (TUBB8)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    347688 (TUBB8)
   05132 Salmonella infection
    347688 (TUBB8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    347688 (TUBB8)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    347688 (TUBB8)
   04147 Exosome [BR:hsa04147]
    347688 (TUBB8)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     347688 (TUBB8)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    347688 (TUBB8)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   347688 (TUBB8)
  Exosomal proteins of colorectal cancer cells
   347688 (TUBB8)
  Exosomal proteins of bladder cancer cells
   347688 (TUBB8)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 347688
NCBI-ProteinID: NP_817124
OMIM: 616768
HGNC: 20773
Ensembl: ENSG00000261456
Vega: OTTHUMG00000174803
Pharos: Q3ZCM7(Tclin)
UniProt: Q3ZCM7
LinkDB
Position
10p15.3
AA seq 444 aa
MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV
PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG
LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgagggagatcgtgctcacgcagatcgggcagtgcgggaatcagatcggcgccaagttc
tgggaggtgatctctgatgaacatgccatcgactccgctggcacctaccacggggacagc
cacctgcagctggagcgcatcaacgtgtactacaacgaggccagcggtggcaggtacgtg
ccccgcgctgtgctcgtggatctggagccgggcaccatggactctgtgcgctcggggccc
ttcgggcaggtcttcaggccagacaacttcatcttcggtcagtgtggggccggaaacaac
tgggccaagggacactacaccgaaggcgcggagctgatggagtcagtgatggacgttgtc
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtacccttctgctcagtaagatccgggaggagtaccca
gacaggatcataaacacattcagcatcctgccctcgcccaaggtgtcggacaccgtggtg
gagccctacaacgccaccctctcagtccaccagctcatagaaaacgcagatgagaccttt
tgcatagataacgaagctctgtatgacatatgttccaagaccctaaaactgcccacaccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacgtgcctg
cgcttcccgggccagctgaatgctgacctgcggaagctggccgtgaacatggtcccgttt
ccccggctgcatttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggccttgactgtggctgagcttacccagcagatgtttgatgctaagaacatgatg
gctgcctgtgacccccgtcacggccgctacctaacggcggctgccattttcaggggtcgc
atgcccatgagggaggtggatgaacaaatgttcaacattcaagataagaacagcagttac
tttgctgactggctccccaacaacgtaaaaacagccgtctgtgacatcccaccccggggg
ctaaaaatgtcagccaccttcattgggaataatacggccatccaggaactcttcaagcgt
gtctcagagcagtttacagcaatgttcaggcgcaaggccttcctccactggtacacgggc
gagggcatggatgagatggaattcaccgaggccgagagcaacatgaacgacctggtgtct
gaatatcagcaatatcaggatgccacggccgaggaggaggaggatgaggagtatgccgag
gaggaggtggcctag

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