KEGG   Homo sapiens (human): 8325Help
Entry
8325              CDS       T01001                                 

Gene name
FZD8, FZ-8, hFZ8
Definition
(RefSeq) frizzled class receptor 8
  KO
K02375  frizzled 5/8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04150  mTOR signaling pathway
hsa04310  Wnt signaling pathway
hsa04390  Hippo signaling pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04916  Melanogenesis
hsa04934  Cushing syndrome
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06115  WNT signaling (viruses)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06215  WNT signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
  Element
N00056  Wnt signaling pathway
N00060  LRP6-overexpression to Wnt signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    8325 (FZD8)
   04390 Hippo signaling pathway
    8325 (FZD8)
   04150 mTOR signaling pathway
    8325 (FZD8)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    8325 (FZD8)
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    8325 (FZD8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    8325 (FZD8)
   05205 Proteoglycans in cancer
    8325 (FZD8)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    8325 (FZD8)
   05226 Gastric cancer
    8325 (FZD8)
   05217 Basal cell carcinoma
    8325 (FZD8)
   05224 Breast cancer
    8325 (FZD8)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    8325 (FZD8)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    8325 (FZD8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    8325 (FZD8)
G protein-coupled receptors [BR:hsa04030]
 Frizzled / Smoothened family
  8325 (FZD8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Frizzled Fz 7tm_2 PhaG_MnhG_YufB
Motif
Other DBs
NCBI-GeneID: 8325
NCBI-ProteinID: NP_114072
OMIM: 606146
HGNC: 4046
Ensembl: ENSG00000177283
Vega: OTTHUMG00000017956
Pharos: Q9H461(Tbio)
UniProt: Q9H461
LinkDB All DBs
Structure
PDB: 

Position
10p11.21
AA seq 694 aa AA seqDB search
MEWGYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHD
TQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAP
LMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGS
GHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVS
VSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFL
IDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGA
GAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLT
WFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDN
LRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLY
TVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITS
GVWVWSGKTLESWRSLCTRCCWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGG
GGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
NT seq 2085 nt NT seq  +upstreamnt  +downstreamnt
atggagtggggttacctgttggaagtgacctcgctgctggccgccttggcgctgctgcag
cgctctagcggcgctgcggccgcctcggccaaggagctggcatgccaagagatcaccgtg
ccgctgtgtaagggcatcggctacaactacacctacatgcccaatcagttcaaccacgac
acgcaagacgaggcgggcctggaggtgcaccagttctggccgctggtggagatccagtgc
tcgcccgatctcaagttcttcctgtgcagcatgtacacgcccatctgcctagaggactac
aagaagccgctgccgccctgccgctcggtgtgcgagcgcgccaaggccggctgcgcgccg
ctcatgcgccagtacggcttcgcctggcccgaccgcatgcgctgcgaccggctgcccgag
caaggcaaccctgacacgctgtgcatggactacaaccgcaccgacctaaccaccgccgcg
cccagcccgccgcgccgcctgccgccgccgccgcccggcgagcagccgccttcgggcagc
ggccacggccgcccgccgggggccaggcccccgcaccgcggcggcggcaggggcggtggc
ggcggggacgcggcggcgcccccagctcgcggcggcggcggtggcgggaaggcgcggccc
cctggcggcggcgcggctccctgcgagcccgggtgccagtgccgcgcgcctatggtgagc
gtgtccagcgagcgccacccgctctacaaccgcgtcaagacaggccagatcgctaactgc
gcgctgccctgccacaacccctttttcagccaggacgagcgcgccttcaccgtcttctgg
atcggcctgtggtcggtgctctgcttcgtgtccaccttcgccaccgtctccaccttcctt
atcgacatggagcgcttcaagtacccggagcggcccattatcttcctctcggcctgctac
ctcttcgtgtcggtgggctacctagtgcgcctggtggcgggccacgagaaggtggcgtgc
agcggtggcgcgccgggcgcggggggcgctgggggcgcgggcggcgcggcggcgggcgcg
ggcgcggcgggcgcgggcgcgggcggcccgggcgggcgcggcgagtacgaggagctgggc
gcggtggagcagcacgtgcgctacgagaccaccggccccgcgctgtgcaccgtggtcttc
ttgctggtctacttcttcggcatggccagctccatctggtgggtgatcttgtcgctcaca
tggttcctggcggccggtatgaagtggggcaacgaagccatcgccggctactcgcagtac
ttccacctggccgcgtggcttgtgcccagcgtcaagtccatcgcggtgctggcgctcagc
tcggtggacggcgacccggtggcgggcatctgctacgtgggcaaccagagcctggacaac
ctgcgcggcttcgtgctggcgccgctggtcatctacctcttcatcggcaccatgttcctg
ctggccggcttcgtgtccctcttccgcatccgctcggtcatcaagcaacaggacggcccc
accaagacgcacaagctggagaagctgatgatccgcctgggcctgttcaccgtgctctac
accgtgcccgccgcggtggtggtcgcctgcctcttctacgagcagcacaaccgcccgcgc
tgggaggccacgcacaactgcccgtgcctgcgggacctgcagcccgaccaggcacgcagg
cccgactacgccgtcttcatgctcaagtacttcatgtgcctagtggtgggcatcacctcg
ggcgtgtgggtctggtccggcaagacgctggagtcctggcgctccctgtgcacccgctgc
tgctgggccagcaagggcgccgcggtgggcgggggcgcgggcgccacggccgcggggggt
ggcggcgggccggggggcggcggcggcgggggacccggcggcggcggggggccgggcggc
ggcgggggctccctctacagcgacgtcagcactggcctgacgtggcggtcgggcacggcg
agctccgtgtcttatccaaagcagatgccattgtcccaggtctga

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