Homo sapiens (human): 834
Entry
834 CDS
T01001
Gene name
CASP1, ICE, IL1BC, P45
Definition
(RefSeq) caspase 1
KO
K01370
caspase 1 [EC:
3.4.22.36
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04217
Necroptosis
hsa04621
NOD-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04625
C-type lectin receptor signaling pathway
hsa05014
Amyotrophic lateral sclerosis (ALS)
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05135
Yersinia infection
hsa05164
Influenza A
Network
nt06139
NLR signaling (viruses and bacteria)
nt06170
Influenza A virus (IAV)
Element
N00742
NLRP3 Inflammasome signaling pathway
N00743
IAV NS1 to NLRP3 inflammasome signaling pathway
N00863
Yersinia YopM to NLRP3 Inflammasome signaling pathway
N00864
Yersinia YopK to NLRP3 Inflammasome signaling pathway
N00865
Yersinia YopK to NLRC4 Inflammasome signaling pathway
N00866
Yersinia YopM to Pyrin Inflammasome signaling pathway
N00867
NLRC4 Inflammasome signaling pathway
N00868
Pyrin Inflammasome signaling pathway
N00933
Escherichia NleA to NLRP3 inflammasome signaling pathway
N00934
Non-canonical inflammasome signaling pathway
N00935
Escherichia NleF to non-canonical inflammasome signaling pathway
N00948
Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway
N00949
Shigella IpaB to NLRC4 Inflammasome signaling pathway
Drug target
Belnacasan:
D10416
Emricasan:
D10004
Nivocasan:
D09938
Pralnacasan:
D08978
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
834 (CASP1)
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
834 (CASP1)
04623 Cytosolic DNA-sensing pathway
834 (CASP1)
04625 C-type lectin receptor signaling pathway
834 (CASP1)
09160 Human Diseases
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis (ALS)
834 (CASP1)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
834 (CASP1)
05132 Salmonella infection
834 (CASP1)
05131 Shigellosis
834 (CASP1)
05135 Yersinia infection
834 (CASP1)
05133 Pertussis
834 (CASP1)
05134 Legionellosis
834 (CASP1)
09172 Infectious disease: viral
05164 Influenza A
834 (CASP1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
834 (CASP1)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
834 (CASP1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.36 caspase-1
834 (CASP1)
Peptidases and inhibitors [BR:
hsa01002
]
Cysteine peptidases
Family C14: caspase family
834 (CASP1)
Membrane trafficking [BR:
hsa04131
]
Autophagy
Other autophagy associated proteins
TRIM-directed selective autophagy
834 (CASP1)
SSDB
Motif
Pfam:
Peptidase_C14
CARD
Other DBs
NCBI-GeneID:
834
NCBI-ProteinID:
NP_001244047
OMIM:
147678
HGNC:
1499
Ensembl:
ENSG00000137752
Vega:
OTTHUMG00000048072
Pharos:
P29466
(Tchem)
UniProt:
P29466
A8K249
LinkDB
Structure
PDB:
6BZ9
6F6R
3D6M
2HBQ
2H54
1SC3
1RWX
3D6F
2HBZ
2H4Y
3D6H
2H4W
1RWN
3E4C
2HBY
2H51
1SC4
1RWV
1RWO
5MMV
2HBR
2H48
1RWP
1RWK
1BMQ
5MTK
3NS7
1SC1
1ICE
1RWM
1IBC
1RWW
2FQQ
5FNA
Position
11q22.3
AA seq
404 aa
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
NT seq
1215 nt
+upstream
nt +downstream
nt
atggccgacaaggtcctgaaggagaagagaaagctgtttatccgttccatgggtgaaggt
acaataaatggcttactggatgaattattacagacaagggtgctgaacaaggaagagatg
gagaaagtaaaacgtgaaaatgctacagttatggataagacccgagctttgattgactcc
gttattccgaaaggggcacaggcatgccaaatttgcatcacatacatttgtgaagaagac
agttacctggcagggacgctgggactctcagcagatcaaacatctggaaattaccttaat
atgcaagactctcaaggagtactttcttcctttccagctcctcaggcagtgcaggacaac
ccagctatgcccacatcctcaggctcagaagggaatgtcaagctttgctccctagaagaa
gctcaaaggatatggaaacaaaagtcggcagagatttatccaataatggacaagtcaagc
cgcacacgtcttgctctcattatctgcaatgaagaatttgacagtattcctagaagaact
ggagctgaggttgacatcacaggcatgacaatgctgctacaaaatctggggtacagcgta
gatgtgaaaaaaaatctcactgcttcggacatgactacagagctggaggcatttgcacac
cgcccagagcacaagacctctgacagcacgttcctggtgttcatgtctcatggtattcgg
gaaggcatttgtgggaagaaacactctgagcaagtcccagatatactacaactcaatgca
atctttaacatgttgaataccaagaactgcccaagtttgaaggacaaaccgaaggtgatc
atcatccaggcctgccgtggtgacagccctggtgtggtgtggtttaaagattcagtagga
gtttctggaaacctatctttaccaactacagaagagtttgaggatgatgctattaagaaa
gcccacatagagaaggattttatcgctttctgctcttccacaccagataatgtttcttgg
agacatcccacaatgggctctgtttttattggaagactcattgaacatatgcaagaatat
gcctgttcctgtgatgtggaggaaattttccgcaaggttcgattttcatttgagcagcca
gatggtagagcgcagatgcccaccactgaaagagtgactttgacaagatgtttctacctc
ttcccaggacattaa
DBGET
integrated database retrieval system
