KEGG   Homo sapiens (human): 836Help
Entry
836               CDS       T01001                                 

Gene name
CASP3, CPP32, CPP32B, SCA-1
Definition
(RefSeq) caspase 3
  KO
K02187  caspase 3 [EC:3.4.22.56]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04010  MAPK signaling pathway
hsa04115  p53 signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04650  Natural killer cell mediated cytotoxicity
hsa04657  IL-17 signaling pathway
hsa04668  TNF signaling pathway
hsa04726  Serotonergic synapse
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis (ALS)
hsa05016  Huntington disease
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05222  Small cell lung cancer
hsa05416  Viral myocarditis
Network
nt06131  Apoptosis (virus)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06231  Apoptosis
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
  Element
N00098  Intrinsic apoptotic pathway
N00100  BCL2-overexpression to intrinsic apoptotic pathway
N00101  DCC-apoptotic pathway
N00102  Loss of DCC to DCC-apoptotic pathway
N00145  Extrinsic apoptotic pathway
N00146  Crosstalk between extrinsic and intrinsic apoptotic pathways
N00164  KSHV vBCL2 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00165  KSHV vIAP to crosstalk between extrinsic and intrinsic apoptotic pathways
N00262  EBV EBNA3C to intrinsic apoptotic pathway
N00350  HPV E6 to extrinsic apoptotic pathway
N00351  HPV E6 to extrinsic apoptotic pathway
N00352  HPV E6 to extrinsic apoptotic pathway
N00425  HCMV UL36 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00426  HCMV UL37x1 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00449  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00450  HIV Tat to intrinsic apoptotic pathway
N00451  HIV Tat to intrinsic apoptotic pathway
N00452  HIV Nef to intrinsic apoptotic pathway
N00453  HIV Vpr to intrinsic apoptotic pathway
N00454  HIV Vpr to intrinsic apoptotic pathway
N00474  EBV BHRF1 to intrinsic apoptotic pathway
N00475  EBV BHRF1 to intrinsic apoptotic pathway
N00476  EBV BHRF1 to intrinsic apoptotic pathway
N00477  EBV BHRF1 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00478  EBV BARF1 to intrinsic apoptotic pathway
N00524  HCV NS5A to extrinsic apoptotic pathway
N00526  HCV NS3 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00527  HCV Core to crosstalk between extrinsic and intrinsic apoptotic pathways
N00528  HCV core to extrinsic apoptotic pathway
N00533  HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
N00534  HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
N00579  HSV ICP6 to extrinsic apoptotic pathway
N00580  HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00585  HSV US3 to intrinsic apoptotic pathway
N00745  IAV PB1-F2 to intrinsic apoptotic pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    836 (CASP3)
   04668 TNF signaling pathway
    836 (CASP3)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    836 (CASP3)
   04215 Apoptosis - multiple species
    836 (CASP3)
   04115 p53 signaling pathway
    836 (CASP3)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    836 (CASP3)
   04657 IL-17 signaling pathway
    836 (CASP3)
  09156 Nervous system
   04726 Serotonergic synapse
    836 (CASP3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    836 (CASP3)
   05206 MicroRNAs in cancer
    836 (CASP3)
   05205 Proteoglycans in cancer
    836 (CASP3)
   05203 Viral carcinogenesis
    836 (CASP3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    836 (CASP3)
   05222 Small cell lung cancer
    836 (CASP3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    836 (CASP3)
   05012 Parkinson disease
    836 (CASP3)
   05014 Amyotrophic lateral sclerosis (ALS)
    836 (CASP3)
   05016 Huntington disease
    836 (CASP3)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    836 (CASP3)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    836 (CASP3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    836 (CASP3)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    836 (CASP3)
   05133 Pertussis
    836 (CASP3)
   05134 Legionellosis
    836 (CASP3)
   05152 Tuberculosis
    836 (CASP3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    836 (CASP3)
   05162 Measles
    836 (CASP3)
   05164 Influenza A
    836 (CASP3)
   05161 Hepatitis B
    836 (CASP3)
   05160 Hepatitis C
    836 (CASP3)
   05168 Herpes simplex virus 1 infection
    836 (CASP3)
   05163 Human cytomegalovirus infection
    836 (CASP3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    836 (CASP3)
   05169 Epstein-Barr virus infection
    836 (CASP3)
   05165 Human papillomavirus infection
    836 (CASP3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    836 (CASP3)
   05145 Toxoplasmosis
    836 (CASP3)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    836 (CASP3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases [BR:hsa01002]
    836 (CASP3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.56  caspase-3
     836 (CASP3)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C14: caspase family
   836 (CASP3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Peptidase_C14
Motif
Other DBs
NCBI-GeneID: 836
NCBI-ProteinID: NP_004337
OMIM: 600636
HGNC: 1504
Ensembl: ENSG00000164305
Vega: OTTHUMG00000133681
Pharos: P42574(Tchem)
UniProt: P42574
LinkDB All DBs
Structure
PDB: 

Position
4q35.1
AA seq 277 aa AA seqDB search
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
NT seq 834 nt NT seq  +upstreamnt  +downstreamnt
atggagaacactgaaaactcagtggattcaaaatccattaaaaatttggaaccaaagatc
atacatggaagcgaatcaatggactctggaatatccctggacaacagttataaaatggat
tatcctgagatgggtttatgtataataattaataataagaattttcataaaagcactgga
atgacatctcggtctggtacagatgtcgatgcagcaaacctcagggaaacattcagaaac
ttgaaatatgaagtcaggaataaaaatgatcttacacgtgaagaaattgtggaattgatg
cgtgatgtttctaaagaagatcacagcaaaaggagcagttttgtttgtgtgcttctgagc
catggtgaagaaggaataatttttggaacaaatggacctgttgacctgaaaaaaataaca
aactttttcagaggggatcgttgtagaagtctaactggaaaacccaaacttttcattatt
caggcctgccgtggtacagaactggactgtggcattgagacagacagtggtgttgatgat
gacatggcgtgtcataaaataccagtggaggccgacttcttgtatgcatactccacagca
cctggttattattcttggcgaaattcaaaggatggctcctggttcatccagtcgctttgt
gccatgctgaaacagtatgccgacaagcttgaatttatgcacattcttacccgggttaac
cgaaaggtggcaacagaatttgagtccttttcctttgacgctacttttcatgcaaagaaa
cagattccatgtattgtttccatgctcacaaaagaactctatttttatcactaa

KEGG   Homo sapiens (human): 840Help
Entry
840               CDS       T01001                                 

Gene name
CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3
Definition
(RefSeq) caspase 7
  KO
K04397  caspase 7 [EC:3.4.22.60]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04668  TNF signaling pathway
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05200  Pathways in cancer
Network
nt06131  Apoptosis (virus)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06231  Apoptosis
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
  Element
N00098  Intrinsic apoptotic pathway
N00100  BCL2-overexpression to intrinsic apoptotic pathway
N00145  Extrinsic apoptotic pathway
N00146  Crosstalk between extrinsic and intrinsic apoptotic pathways
N00449  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00450  HIV Tat to intrinsic apoptotic pathway
N00451  HIV Tat to intrinsic apoptotic pathway
N00452  HIV Nef to intrinsic apoptotic pathway
N00453  HIV Vpr to intrinsic apoptotic pathway
N00454  HIV Vpr to intrinsic apoptotic pathway
N00585  HSV US3 to intrinsic apoptotic pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    840 (CASP7)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    840 (CASP7)
   04215 Apoptosis - multiple species
    840 (CASP7)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    840 (CASP7)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    840 (CASP7)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    840 (CASP7)
  09171 Infectious disease: bacterial
   05133 Pertussis
    840 (CASP7)
   05134 Legionellosis
    840 (CASP7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases [BR:hsa01002]
    840 (CASP7)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.60  caspase-7
     840 (CASP7)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C14: caspase family
   840 (CASP7)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Peptidase_C14 EZH2_N
Motif
Other DBs
NCBI-GeneID: 840
NCBI-ProteinID: NP_001218
OMIM: 601761
HGNC: 1508
Ensembl: ENSG00000165806
Vega: OTTHUMG00000019076
Pharos: P55210(Tchem)
UniProt: P55210
LinkDB All DBs
Structure
PDB: 

Position
10q25.3
AA seq 303 aa AA seqDB search
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
NT seq 912 nt NT seq  +upstreamnt  +downstreamnt
atggcagatgatcagggctgtattgaagagcagggggttgaggattcagcaaatgaagat
tcagtggatgctaagccagaccggtcctcgtttgtaccgtccctcttcagtaagaagaag
aaaaatgtcaccatgcgatccatcaagaccacccgggaccgagtgcctacatatcagtac
aacatgaattttgaaaagctgggcaaatgcatcataataaacaacaagaactttgataaa
gtgacaggtatgggcgttcgaaacggaacagacaaagatgccgaggcgctcttcaagtgc
ttccgaagcctgggttttgacgtgattgtctataatgactgctcttgtgccaagatgcaa
gatctgcttaaaaaagcttctgaagaggaccatacaaatgccgcctgcttcgcctgcatc
ctcttaagccatggagaagaaaatgtaatttatgggaaagatggtgtcacaccaataaag
gatttgacagcccactttaggggggatagatgcaaaacccttttagagaaacccaaactc
ttcttcattcaggcttgccgagggaccgagcttgatgatggcatccaggccgactcgggg
cccatcaatgacacagatgctaatcctcgatacaagatcccagtggaagctgacttcctc
ttcgcctattccacggttccaggctattactcgtggaggagcccaggaagaggctcctgg
tttgtgcaagccctctgctccatcctggaggagcacggaaaagacctggaaatcatgcag
atcctcaccagggtgaatgacagagttgccaggcactttgagtctcagtctgatgaccca
cacttccatgagaagaagcagatcccctgtgtggtctccatgctcaccaaggaactctac
ttcagtcaatag

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