KEGG   Homo sapiens (human): 8408
Entry
8408              CDS       T01001                                 

Gene name
ULK1, ATG1, ATG1A, UNC51, Unc51.1, hATG1
Definition
(RefSeq) unc-51 like autophagy activating kinase 1
  KO
K21357  serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06128  Autophagy (viruses and bacteria)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06228  Autophagy
nt06413  Autophagy
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06464  Amyotrophic lateral sclerosis
  Element
N00155  Autophagy-vesicle nucleation
N01142  C9orf72-mediated autophagy initiation
N01143  Mutation-inactivated C9orf72 to C9orf72-mediated autophagy initiation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    8408 (ULK1)
   04150 mTOR signaling pathway
    8408 (ULK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    8408 (ULK1)
   04137 Mitophagy - animal
    8408 (ULK1)
 09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    8408 (ULK1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    8408 (ULK1)
   05014 Amyotrophic lateral sclerosis
    8408 (ULK1)
   05016 Huntington disease
    8408 (ULK1)
   05017 Spinocerebellar ataxia
    8408 (ULK1)
   05022 Pathways of neurodegeneration - multiple diseases
    8408 (ULK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    8408 (ULK1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8408 (ULK1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    8408 (ULK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     8408 (ULK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  ULK family [OT]
   8408 (ULK1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Autophagosome formation proteins
   ULK complex
    8408 (ULK1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    8408 (ULK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr DUF3543 Kdo RIO1 Pkinase_fungal APH Kinase-like
Other DBs
NCBI-GeneID: 8408
NCBI-ProteinID: NP_003556
OMIM: 603168
HGNC: 12558
Ensembl: ENSG00000177169
Vega: OTTHUMG00000168052
Pharos: O75385(Tchem)
UniProt: O75385
LinkDB
Structure
PDB: 
4WNO 6MNH 5CI7 6QAS 4WNP

Position
12q24.33
AA seq 1050 aa
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ
QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGS
GSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV
PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGP
FSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSP
PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA
PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCR
NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRT
LPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL
QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTG
SASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEH
TEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQL
VLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRF
FLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHM
LSDQADIENVTKCKLCIERRLSALLTGICA
NT seq 3153 nt   +upstreamnt  +downstreamnt
atggagcccggccgcggcggcacagagaccgtgggcaagttcgagttctcccgcaaggac
ctgatcggccacggcgccttcgcggtggtcttcaagggccgccaccgcgagaagcacgat
ttggaggtcgccgtcaagtgcattaacaagaagaacctcgccaagtctcagacgctgctg
gggaaggaaatcaaaatcctgaaggaactgaaacatgaaaacatcgtggccctgtacgac
ttccaggaaatggctaattctgtctacctggttatggagtactgcaacggtggggacctg
gccgactacctgcacgccatgcgcacgctgagcgaggacaccatcaggctcttcctgcag
cagatcgcgggcgccatgcggcttctgcacagcaaaggcatcatccaccgcgacctgaaa
ccgcagaacatcctgctgtccaaccccgccggccgccgcgccaaccccaacagcatccgc
gtcaagatcgctgacttcggcttcgcgcggtacctccagagcaacatgatggcggccaca
ctctgcggctcccccatgtacatggcccccgaggtcatcatgtcccagcactacgacggg
aaggcggacctgtggagcatcggcaccatcgtctaccagtgcctgacggggaaggcgccc
ttccaggccagcagcccccaggacctgcgcctgttctacgagaagaacaagacgttggtc
cccaccatcccccgggagacctcggccccgctgcggcagctgctcctggccctactgcaa
cgcaaccacaaggaccgcatggacttcgatgagttttttcatcaccctttcctcgatgcc
agcccctcggtcaggaaatccccacccgtgcctgtgccctcgtacccaagctcggggtcc
ggcagcagctccagcagcagctccacctcccacctggcctccccgccgtccctgggcgag
atgcagcagctgcagaagaccctggcctccccggctgacaccgctggcttcctgcacagc
tcccgggactctggtggcagcaaggactcttcctgtgacacagacgacttcgtcatggtc
cccgcgcagtttccaggtgacctggtggctgaggcgcccagtgccaaacccccgccagac
agcctgatgtgcagtgggagctcactggtggcctctgcgggcttggagagccacggccgg
accccatctccatccccaccctgcagcagctcccccagtccctcaggccgggctggcccg
ttctccagcagcaggtgcggcgcctctgtccccatcccagtccccacgcaggtgcagaac
taccagcgcattgagcgaaacctgcagtcacccacccagttccaaacacctcggtcctct
gccatccgcaggtcaggcagcaccagccccctgggctttgcaagggccagcccctcgccc
cctgcccacgctgagcatggaggcgtcctggccaggaagatgtctctgggtggaggccgg
ccctacacgccatctcctcaagttggaaccatccctgagcggccaggctggagcgggacg
ccctccccacagggagctgagatgcggggtggcaggtcccctcgtccaggctcctctgca
cccgagcactctccccgcacttccgggctgggctgccgcctgcacagcgcccccaacctg
tctgacttgcacgtcgtccgccccaagctgcccaaaccccccacggaccccctgggagct
gtgttcagcccaccacaggccagccctccccagccgtcccacggcctgcagtcctgccgg
aacctgcggggctcacccaagctgcccgacttcctgcagcgaaaccccctgccccccatc
ctgggctcccccaccaaggctgtgccctcctttgacttcccgaagacccccagctcccag
aacctgctggccctcctagcccggcagggcgtggtgatgacgccccctcgaaaccggacg
ctgcccgacctctcggaggtgggacccttccatggtcagccgttgggccctggcctgcgg
ccaggcgaggaccccaagggcccctttggccggtctttcagcaccagccgcctcactgac
ctgctccttaaggcggcgtttgggacacaagccccggacccgggcagcacggagagcctg
caggagaagcccatggagatcgcaccctcagctggctttggagggagcctgcacccagga
gcccgtgctgggggcaccagcagcccttccccggtggtcttcaccgtgggctctcccccg
agcgggagcacgcccccccagggcccccgcaccaggatgttctcagcgggccccactggc
tctgccagctcttctgcccgccacctggtgcctgggccctgcagcgaggccccagcccct
gagctccctgctccaggacacggctgcagctttgccgaccccattactgcgaacctggag
ggggctgtgaccttcgaggcccccgacctccctgaggagaccctcatggagcaagagcac
acggagatcctgcgtggcctgcgcttcacgctgctgttcgtgcagcacgtcctggagatc
gcagccctgaagggcagcgccagtgaggcggcggggggccctgagtaccagctgcaggag
agtgtggtggccgaccagatcagcctgctgagccgagaatggggcttcgcggaacagctg
gtgctgtacctgaaggtggccgagctactgtcctccggcctgcaaagtgccatcgaccag
atccgggccggcaagctctgcctgtcgtccactgtgaagcaggtggtgcgcaggctgaat
gagctgtacaaggccagcgtggtgtcctgccagggcctgagcctgcggctgcagcgcttc
ttcctggacaagcagcggctcctggaccgcattcacagcatcactgccgagaggctcatc
ttcagccacgctgtgcagatggtgcagtcggctgccctggacgagatgttccagcaccgt
gagggctgcgtcccacgctaccacaaggccctgctgctcctggaggggctgcagcacatg
ctctcggaccaggccgacatcgagaacgtcaccaagtgcaagctgtgcattgagcggaga
ctctcggcgctgctgactggcatctgtgcctga

KEGG   Homo sapiens (human): 9706
Entry
9706              CDS       T01001                                 

Gene name
ULK2, ATG1B, Unc51.2
Definition
(RefSeq) unc-51 like autophagy activating kinase 2
  KO
K08269  serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    9706 (ULK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    9706 (ULK2)
   04136 Autophagy - other
    9706 (ULK2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    9706 (ULK2)
   05014 Amyotrophic lateral sclerosis
    9706 (ULK2)
   05016 Huntington disease
    9706 (ULK2)
   05017 Spinocerebellar ataxia
    9706 (ULK2)
   05022 Pathways of neurodegeneration - multiple diseases
    9706 (ULK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9706 (ULK2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    9706 (ULK2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    9706 (ULK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     9706 (ULK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  ULK family [OT]
   9706 (ULK2)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Autophagosome formation proteins
   Atg1 complex
    9706 (ULK2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    9706 (ULK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr DUF3543 Kdo RIO1 Pkinase_fungal APH Kinase-like
Other DBs
NCBI-GeneID: 9706
NCBI-ProteinID: NP_001136082
OMIM: 608650
HGNC: 13480
Ensembl: ENSG00000083290
Vega: OTTHUMG00000059511
Pharos: Q8IYT8(Tchem)
UniProt: Q8IYT8
LinkDB
Structure
PDB: 
6QAV 6QAU 6QAT

Position
17p11.2
AA seq 1036 aa
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR
ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET
SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP
SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI
SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST
ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL
VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ
KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS
PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS
KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS
KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS
PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV
LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH
LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT
AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC
SIERRLSALCHSTATV
NT seq 3111 nt   +upstreamnt  +downstreamnt
atggaggtggtgggtgacttcgagtacagcaagagggatctcgtgggacacggggccttc
gccgtggtcttccgggggcggcaccgccagaaaactgattgggaggtagctattaaaagt
attaataaaaagaacttgtcaaaatcacaaatactgcttggaaaggaaattaaaatctta
aaggaacttcagcatgaaaatattgtagcactctatgatgttcaggaattacccaactct
gtctttttggtgatggagtattgcaatggtggagacctcgcagattatttgcaagcgaaa
gggactctcagtgaagacacgatcagagtgtttctgcatcagattgctgctgccatgcga
atcctgcacagcaaaggaatcatccacagagatctcaaaccacagaacatcttgctgtcc
tatgccaatcgcagaaaatcaagtgtcagtggtattcgcatcaaaatagcggattttggt
tttgctcgttacctacatagtaacatgatggctgcaacactgtgtggatccccgatgtac
atggctcctgaggttattatgtctcaacattatgatgctaaggctgacttgtggagcata
ggaacagtgatataccaatgcctagttggaaaaccaccttttcaggccaatagtcctcaa
gacttaaggatgttttatgaaaaaaacaggagcttaatgcctagtattcccagagaaaca
tcaccttatttggctaatctccttttgggtttgcttcagagaaaccaaaaagatagaatg
gactttgaagcattttttagccatccttttcttgagcaaggtccagtaaaaaaatcttgc
ccagttccagtgcccatgtattctggttctgtctctggaagctcctgtggcagctctcca
tcttgtcgttttgcttctccaccatcccttccagatatgcagcatattcaggaagaaaac
ttatcttccccaccattgggtcctcccaactatctacaagtttccaaagattctgccagt
actagtagcaagaactcttcttgtgacacggatgactttgttttggtgccacacaacatc
tcgtcagaccactcatgtgatatgccagtggggactgctggcagacgtgcttcaaatgaa
ttcttggtgtgtggagggcagtgtcagcctactgtgtcacctcacagcgaaacagcacca
attccagttcctactcaaataaggaattatcagcgcatagagcagaatcttacatctact
gccagctcaggcacaaatgtacatggttctccaagatctgcagtggtacgaaggtccaac
accagccccatgggcttcctccggccgggatcatgctccccagtaccagcagacacagca
cagacagttggacgaaggctctccactgggtcttctaggccttactcaccttcccctttg
gttggtaccattcctgagcaattcagtcagtgctgctgtgggcatcctcagggccatgac
tccaggagtagaaactcctcaggttctccagtgccacaagctcagtccccacagtctctc
ttatcgggtgctagactgcagagcgcccccaccctcactgacatctatcagaacaagcag
aagctcagaaaacagcactctgaccccgtgtgcccatcccatactggggctgggtacagc
tactcgcctcagcccagtcggcctggcagccttggaacttctcccaccaagcacttgggg
tcctctccacggagttctgactggttctttaaaactcctttgccaacaatcattggctct
cctactaagaccacagctcctttcaaaatccctaaaactcaagcatcttccaacctgtta
gccttggttactcgtcatgggcctgctgaagaacagtcgaaagatgggaatgagccacgg
gaatgtgcccattgcctcttagtgcaaggaagtgagaggcagcgggccgagcagcagagc
aaggcagtgtttggcagatctgtcagtaccgggaagttatcagatcaacaaggaaagact
cctatatgtcgacatcagggcagcacagacagtttaaatacagaacgaccaatggatata
gctccggcaggagcctgtggtggtgttctggcacctcctgcaggtacagcagcaagttcc
aaggctgtcctcttcactgtagggtctcctccacacagtgcggcagcccccacttgtacc
cacatgttccttcgaacaagaacaacctcagtggggcccagcaactccgggggctctctt
tgtgccatgagtggccgcgtgtgcgtggggtccccgcctggcccaggcttcggctcttcc
cctccaggagcagaggcagctcccagcctgagatacgtgccttacggtgcttcacccccc
agcctagaggggctcatcacctttgaagcccctgaactgccggaggagacgctgatggag
cgggaacacacagacaccttacgccatctgaatgtgatgctgatgttcactgagtgtgtg
ctggacctgacagccatgaggggaggaaaccctgagctgtgcacatctgctgtgtccttg
taccagatccaggagagtgtggtggtggaccagatcagtcagctgagcaaagactggggg
cgggtggagcagctggtgttgtacatgaaagcagcacagctgcttgcggcttctctgcat
cttgccaaagcccagatcaagtccgggaaactgagcccatccacagctgtgaaacaagtt
gtcaagaatctgaacgaacgatataaattctgcatcaccatgtgcaagaaacttacagaa
aagctgaatcgattcttctctgacaaacagaggtttattgatgaaatcaacagtgtgact
gcagagaaactcatctataattgtgctgtagaaatggttcagtctgcagccctggatgag
atgtttcagcagaccgaagatattgtttatcgctatcataaggcagcccttcttttggaa
ggcctaagtaggattctacaggaccctgcagatattgaaaatgtgcataaatataaatgt
agtattgagagaagactgtcggcgctctgccatagcaccgcaaccgtgtga

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