Homo sapiens (human): 867
Help
Entry
867 CDS
T01001
Gene name
CBL, C-CBL, CBL2, FRA11B, NSLL, RNF55
Definition
(RefSeq) Cbl proto-oncogene
KO
K04707
E3 ubiquitin-protein ligase CBL [EC:
2.3.2.27
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04012
ErbB signaling pathway
hsa04120
Ubiquitin mediated proteolysis
hsa04144
Endocytosis
hsa04910
Insulin signaling pathway
hsa05100
Bacterial invasion of epithelial cells
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05220
Chronic myeloid leukemia
Network
nt06214
PI3K signaling
nt06276
Chronic myeloid leukemia
Element
N00048
BCR-ABL fusion kinase to PI3K signaling pathway
Disease
H00523
Noonan syndrome and related disorders
H02190
CBL syndrome
H02410
Myelodysplastic/myeloproliferative neoplasms
H02411
Chronic myelomonocytic leukemia
H02412
Atypical chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
867 (CBL)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
867 (CBL)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
867 (CBL)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
867 (CBL)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
867 (CBL)
05205 Proteoglycans in cancer
867 (CBL)
09162 Cancer: specific types
05220 Chronic myeloid leukemia
867 (CBL)
09171 Infectious disease: bacterial
05100 Bacterial invasion of epithelial cells
867 (CBL)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
867 (CBL)
04121 Ubiquitin system [BR:
hsa04121
]
867 (CBL)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.27 RING-type E3 ubiquitin transferase
867 (CBL)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
867 (CBL)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Single Ring-finger type E3
CBL proteins
867 (CBL)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Cbl_N
Cbl_N3
Cbl_N2
Prok-RING_4
zf-C3HC4_3
zf-C3HC4
zf-RING_2
UBA
zf-C3HC4_2
zf-RING_UBOX
zf-RING_5
zf-rbx1
zf-C3HC4_4
zf-RING_4
Motif
Other DBs
NCBI-GeneID:
867
NCBI-ProteinID:
NP_005179
OMIM:
165360
HGNC:
1541
Ensembl:
ENSG00000110395
Vega:
OTTHUMG00000166170
Pharos:
P22681
(Tbio)
UniProt:
P22681
LinkDB
All DBs
Structure
PDB:
3BUX
3BUW
5HKY
5HKZ
5HKX
3PLF
2Y1N
3BUM
3BUN
1YVH
3OB2
2OO9
2CBL
5HL0
3OB1
1B47
4A49
5HKW
5O76
3BUO
2Y1M
4A4C
4A4B
5J3X
1FBV
4GPL
2K4D
2JUJ
Thumbnails
Position
11q23.3
AA seq
906 aa
AA seq
DB search
MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCW
KLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFME
NLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFR
ITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFE
FDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRL
GQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDH
IKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR
CEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVER
PPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLR
DLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPV
SAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECD
HPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRAC
DCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPP
VPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSC
QQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISS
PAHVAT
NT seq
2721 nt
NT seq
+upstream
nt +downstream
nt
atggccggcaacgtgaagaagagctctggggccgggggcggcagcggctccgggggctcg
ggttcgggtggcctgattgggctcatgaaggacgccttccagccgcaccaccaccaccac
caccacctcagcccccacccgccggggacggtggacaagaagatggtggagaagtgctgg
aagctcatggacaaggtggtgcggttgtgtcagaacccaaagctggcgctaaagaatagc
ccaccttatatcttagacctgctaccagatacctaccagcatctccgtactatcttgtca
agatatgaggggaagatggagacacttggagaaaatgagtattttagggtgtttatggag
aatttgatgaagaaaactaagcaaaccataagcctcttcaaggagggaaaagaaagaatg
tatgaggagaattctcagcctaggcgaaacctaaccaaactgtccctcatcttcagccac
atgctggcagaactaaaaggaatctttccaagtggactctttcagggagacacatttcgg
attactaaagcagatgctgcggaattttggagaaaagcttttggggaaaagacaatagtc
ccttggaagagctttcgacaggctctacatgaagtgcatcccatcagttctgggctggag
gccatggctctgaaatccactattgatctgacctgcaatgattatatttcggtttttgaa
tttgacatctttacccgactctttcagccctggtcctctttgctcaggaattggaacagc
cttgctgtaactcatcctggctacatggcttttttgacgtatgacgaagtgaaagctcgg
ctccagaaattcattcacaaacctggcagttatatcttccggctgagctgtactcgtctg
ggtcagtgggctattgggtatgttactgctgatgggaacattctccagacaatccctcac
aataaacctctcttccaagcactgattgatggcttcagggaaggcttctatttgtttcct
gatggacgaaatcagaatcctgatctgactggcttatgtgaaccaactccccaagaccat
atcaaagtgacccaggaacaatatgaattatactgtgagatgggctccacattccaacta
tgtaaaatatgtgctgaaaatgataaggatgtaaagattgagccctgtggacacctcatg
tgcacatcctgtcttacatcctggcaggaatcagaaggtcagggctgtcctttctgccga
tgtgaaattaaaggtactgaacccatcgtggtagatccgtttgatcctagagggagtggc
agcctgttgaggcaaggagcagagggagctccctccccaaattatgatgatgatgatgat
gaacgagctgatgatactctcttcatgatgaaggaattggctggtgccaaggtggaacgg
ccgccttctccattctccatggccccacaagcttcccttcccccggtgccaccacgactt
gaccttctgccgcagcgagtatgtgttccctcaagtgcttctgctcttggaactgcttct
aaggctgcttctggctcccttcataaagacaaaccattgccagtacctcccacacttcga
gatcttccaccaccaccgcctccagaccggccatattctgttggagcagaatcccgacct
caaagacgccccttgccttgtacaccaggcgactgtccctccagagacaaactgccccct
gtcccctctagccgccttggagactcatggctgccccggccaatccccaaagtaccagta
tctgccccaagttccagtgatccctggacaggaagagaattaaccaaccggcactcactt
ccattttcattgccctcacaaatggagcccagaccagatgtgcctaggctcggaagcacg
ttcagtctggatacctccatgagtatgaatagcagcccattagtaggtccagagtgtgac
caccccaaaatcaaaccttcctcatctgccaatgccatttattctctggctgccagacct
cttcctgtgccaaaactgccacctggggagcaatgtgagggtgaagaggacacagagtac
atgactccctcttccaggcctctacggcctttggatacatcccagagttcacgagcatgt
gattgcgaccagcagattgatagctgtacgtatgaagcaatgtataatattcagtcccag
gcgccatctatcaccgagagcagcacctttggtgaagggaatttggccgcagcccatgcc
aacactggtcccgaggagtcagaaaatgaggatgatgggtatgatgtcccaaagccacct
gtgccggccgtgctggcccgccgaactctctcagatatctctaatgccagctcctccttt
ggctggttgtctctggatggtgatcctacaacaaatgtcactgaaggttcccaagttccc
gagaggcctccaaaaccattcccgcggagaatcaactctgaacggaaagctggcagctgt
cagcaaggtagtggtcctgccgcctctgctgccaccgcctcacctcagctctccagtgag
atcgagaacctcatgagtcaggggtactcctaccaggacatccagaaagctttggtcatt
gcccagaacaacatcgagatggccaaaaacatcctccgggaatttgtttccatttcttct
cctgcccatgtagctacctag
Homo sapiens (human): 868
Help
Entry
868 CDS
T01001
Gene name
CBLB, Cbl-b, Nbla00127, RNF56
Definition
(RefSeq) Cbl proto-oncogene B
KO
K22517
E3 ubiquitin-protein ligase CBL-B [EC:
2.3.2.27
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04012
ErbB signaling pathway
hsa04120
Ubiquitin mediated proteolysis
hsa04144
Endocytosis
hsa04625
C-type lectin receptor signaling pathway
hsa04660
T cell receptor signaling pathway
hsa04910
Insulin signaling pathway
hsa05162
Measles
Network
nt06114
PI3K signaling (viruses)
nt06169
Measles virus (MV)
Element
N00684
MV F/H to CD28-PI3K signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
868 (CBLB)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
868 (CBLB)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
868 (CBLB)
09150 Organismal Systems
09151 Immune system
04625 C-type lectin receptor signaling pathway
868 (CBLB)
04660 T cell receptor signaling pathway
868 (CBLB)
09152 Endocrine system
04910 Insulin signaling pathway
868 (CBLB)
09160 Human Diseases
09172 Infectious disease: viral
05162 Measles
868 (CBLB)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
868 (CBLB)
04121 Ubiquitin system [BR:
hsa04121
]
868 (CBLB)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.27 RING-type E3 ubiquitin transferase
868 (CBLB)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
868 (CBLB)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Single Ring-finger type E3
CBL proteins
868 (CBLB)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Cbl_N
Cbl_N3
Cbl_N2
Prok-RING_4
zf-C3HC4_3
zf-C3HC4
zf-RING_2
zf-C3HC4_2
zf-RING_UBOX
zf-RING_5
zf-rbx1
zf-C3HC4_4
UBA
zf-RING_4
Motif
Other DBs
NCBI-GeneID:
868
NCBI-ProteinID:
NP_001308717
OMIM:
604491
HGNC:
1542
Ensembl:
ENSG00000114423
Vega:
OTTHUMG00000150654
Pharos:
Q13191
(Tbio)
UniProt:
Q13191
LinkDB
All DBs
Structure
PDB:
2OOA
2OOB
3ZNI
3PFV
3VGO
2LDR
2JNH
2DO6
Thumbnails
Position
3q13.11
AA seq
982 aa
AA seq
DB search
MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLC
QNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKR
AIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAE
FWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLF
QPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYV
TGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQY
ELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEP
IIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTS
PGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQ
DKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFG
TNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHL
GSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLN
SQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPP
ARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPG
SSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQ
APARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNV
EVARSILREFAFPPPVSPRLNL
NT seq
2949 nt
NT seq
+upstream
nt +downstream
nt
atggcaaactcaatgaatggcagaaaccctggtggtcgaggaggaaatccccgaaaaggt
cgaattttgggtattattgatgctattcaggatgcagttggaccccctaagcaagctgcc
gcagatcgcaggaccgtggagaagacttggaagctcatggacaaagtggtaagactgtgc
caaaatcccaaacttcagttgaaaaatagcccaccatatatacttgatattttgcctgat
acatatcagcatttacgacttatattgagtaaatatgatgacaaccagaaacttgcccaa
ctcagtgagaatgagtactttaaaatctacattgatagccttatgaaaaagtcaaaacgg
gcaataagactctttaaagaaggcaaggagagaatgtatgaagaacagtcacaggacaga
cgaaatctcacaaaactgtcccttatcttcagtcacatgctggcagaaatcaaagcaatc
tttcccaatggtcaattccagggagataactttcgtatcacaaaagcagatgctgctgaa
ttctggagaaagttttttggagacaaaactatcgtaccatggaaagtattcagacagtgc
cttcatgaggtccaccagattagctctggcctggaagcaatggctctaaaatcaacaatt
gatttaacttgcaatgattacatttcagtttttgaatttgatatttttaccaggctgttt
cagccttggggctctattttgcggaattggaatttcttagctgtgacacatccaggttac
atggcatttctcacatatgatgaagttaaagcacgactacagaaatatagcaccaaaccc
ggaagctatattttccggttaagttgcactcgattgggacagtgggccattggctatgtg
actggggatgggaatatcttacagaccatacctcataacaagcccttatttcaagccctg
attgatggcagcagggaaggattttatctttatcctgatgggaggagttataatcctgat
ttaactggattatgtgaacctacacctcatgaccatataaaagttacacaggaacaatat
gaattatattgtgaaatgggctccacttttcagctctgtaagatttgtgcagagaatgac
aaagatgtcaagattgagccttgtgggcatttgatgtgcacctcttgccttacggcatgg
caggagtcggatggtcagggctgccctttctgtcgttgtgaaataaaaggaactgagccc
ataatcgtggacccctttgatccaagagatgaaggctccaggtgttgcagcatcattgac
ccctttggcatgccgatgctagacttggacgacgatgatgatcgtgaggagtccttgatg
atgaatcggttggcaaacgtccgaaagtgcactgacaggcagaactcaccagtcacatca
ccaggatcctctccccttgcccagagaagaaagccacagcctgacccactccagatccca
catctaagcctgccacccgtgcctcctcgcctggatctaattcagaaaggcatagttaga
tctccctgtggcagcccaacgggttcaccaaagtcttctccttgcatggtgagaaaacaa
gataaaccactcccagcaccacctcctcccttaagagatcctcctccaccgccacctgaa
agacctccaccaatcccaccagacaatagactgagtagacacatccatcatgtggaaagc
gtgccttccagagacccgccaatgcctcttgaagcatggtgccctcgggatgtgtttggg
actaatcagcttgtgggatgtcgactcctaggggagggctctccaaaacctggaatcaca
gcgagttcaaatgtcaatggaaggcacagtagagtgggctctgacccagtgcttatgcgg
aaacacagacgccatgatttgcctttagaaggagctaaggtcttttccaatggtcacctt
ggaagtgaagaatatgatgttcctccccggctttctcctcctcctccagttaccaccctc
ctccctagcataaagtgtactggtccgttagcaaattctctttcagagaaaacaagagac
ccagtagaggaagatgatgatgaatacaagattccttcatcccaccctgtttccctgaat
tcacaaccatctcattgtcataatgtaaaacctcctgttcggtcttgtgataatggtcac
tgtatgctgaatggaacacatggtccatcttcagagaagaaatcaaacatccctgactta
agcatatatttaaagggagatgtttttgattcagcctctgatcccgtgccattaccacct
gccaggcctccaactcgggacaatccaaagcatggttcttcactcaacaggacgccctct
gattatgatcttctcatccctccattaggtgaagatgcttttgatgccctccctccatct
ctcccacctcccccacctcctgcaaggcatagtctcattgaacattcaaaacctcctggc
tccagtagccggccatcctcaggacaggatctttttcttcttccttcagatccctttgtt
gatctagcaagtggccaagttcctttgcctcctgctagaaggttaccaggtgaaaatgtc
aaaactaacagaacatcacaggactatgatcagcttccttcatgttcagatggttcacag
gcaccagccagaccccctaaaccacgaccgcgcaggactgcaccagaaattcaccacaga
aaaccccatgggcctgaggcggcattggaaaatgtcgatgcaaaaattgcaaaactcatg
ggagagggttatgcctttgaagaggtgaagagagccttagagatagcccagaataatgtc
gaagttgcccggagcatcctccgagaatttgccttccctcctccagtatccccacgtcta
aatctatag
DBGET
integrated database retrieval system
