KEGG   Homo sapiens (human): 9146Help
Entry
9146              CDS       T01001                                 

Gene name
HGS, HRS
Definition
(RefSeq) hepatocyte growth factor-regulated tyrosine kinase substrate
  KO
K12182  hepatocyte growth factor-regulated tyrosine kinase substrate
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
hsa04145  Phagosome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    9146 (HGS)
   04145 Phagosome
    9146 (HGS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    9146 (HGS)
Membrane trafficking [BR:hsa04131]
 Endosome - Lysosome transport
  Endosomal sorting complexes required for transport (ESCRT)
   ESCRT-0 complex
    9146 (HGS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: VHS Hrs_helical FYVE DUF3361 FYVE_2 UIM PIEZO
Motif
Other DBs
NCBI-GeneID: 9146
NCBI-ProteinID: NP_004703
OMIM: 604375
HGNC: 4897
Ensembl: ENSG00000185359
Vega: OTTHUMG00000178109
Pharos: O14964(Tbio)
UniProt: O14964 A0A0S2Z4R4
LinkDB All DBs
Structure
PDB: 

Position
17q25.3
AA seq 777 aa AA seqDB search
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
NT seq 2334 nt NT seq  +upstreamnt  +downstreamnt
atggggcgaggcagcggcaccttcgagcgtctcctagacaaggcgaccagccagctcctg
ttggagacagattgggagtccattttgcagatctgcgacctgatccgccaaggggacaca
caagcaaaatatgctgtgaattccatcaagaagaaagtcaacgacaagaacccacacgtc
gccttgtatgccctggaggtcatggaatctgtggtaaagaactgtggccagacagttcat
gatgaggtggccaacaagcagaccatggaggagctgaaggacctgctgaagagacaagtg
gaggtaaacgtccgtaacaagatcctgtacctgatccaggcctgggcgcatgccttccgg
aacgagcccaagtacaaggtggtccaggacacctaccagatcatgaaggtggaggggcac
gtctttccagaattcaaagagagcgatgccatgtttgctgccgagagagccccagactgg
gtggacgctgaggaatgccaccgctgcagggtgcagttcggggtgatgacccgtaagcac
cactgccgggcgtgtgggcagatattctgtggaaagtgttcttccaagtactccaccatc
cccaagtttggcatcgagaaggaggtgcgcgtgtgtgagccctgctacgagcagctgaac
aggaaagcggagggaaaggccacttccaccactgagctgccccccgagtacctgaccagc
cccctgtctcagcagtcccagctgccccccaagagggacgagacggccctgcaggaggag
gaggagctgcagctggccctggcgctgtcacagtcagaggcggaggagaaggagaggctg
agacagaagtccacgtacacttcgtaccccaaggcggagcccatgccctcggcctcctca
gcgccccccgccagcagcctgtactcttcacctgtgaactcgtcggcgcctctggctgag
gacatcgaccctgagctcgcacggtatctcaaccggaactactgggagaagaagcaggag
gaggctcgcaagagccccacgccatctgcgcccgtgcccctgacggagccggctgcacag
cctggggaagggcacgcagcccccaccaacgtggtggagaaccccctcccggagacagac
tctcagcccattcctccctctggtggcccctttagtgagccacagttccacaatggcgag
tctgaggagagccacgagcagttcctgaaggcgctgcagaacgccgtcaccaccttcgtg
aaccgcatgaagagtaaccacatgcggggccgcagcatcaccaatgactcggccgtgctc
tcactcttccagtccatcaacggcatgcacccgcagctgctggagctgctcaaccagctg
gacgagcgcaggctgtactatgaggggctgcaggacaagctggcacagatccgcgatgcc
cggggggcgctgagtgccctgcgcgaagagcaccgggagaagcttcgccgggcagccgag
gaggcagagcgccagcgccagatccagctggcccagaagctggagataatgcggcagaag
aagcaggagtacctggaggtgcagaggcagctggccatccagcgcctgcaggagcaggag
aaggagcggcagatgcggctggagcagcagaagcagacggtccagatgcgcgcgcagatg
cccgccttccccctgccctacgcccagctccaggccatgcccgcagccggaggtgtgctc
taccagccctcgggaccagccagcttccccagcaccttcagccctgccggctcggtggag
ggctccccaatgcacggcgtgtacatgagccagccggcccctgccgctggcccctacccc
agcatgcccagcactgcggctgatcccagcatggtgagtgcctacatgtacccagcaggg
gccactggggcgcaggcggccccccaggcccaggccggacccaccgccagccccgcttac
tcatcctaccagcctactcccacagcgggctaccagaacgtggcctcccaggccccacag
agcctcccggccatctctcagcctccgcagtccagcaccatgggctacatggggagccag
tcagtctccatgggctaccagccttacaacatgcagaatctcatgaccaccctcccaagc
caggatgcgtctctgccaccccagcagccctacatcgcggggcagcagcccatgtaccag
cagatggcaccctctggcggtcccccccagcagcagccccccgtggcccagcaaccgcag
gcacaggggccgccggcacagggcagcgaggcccagctcatttcattcgactga

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