KEGG   Homo sapiens (human): 925
Entry
925               CDS       T01001                                 

Gene name
CD8A, CD8, Leu2, p32
Definition
(RefSeq) CD8a molecule
  KO
K06458  T-cell surface glycoprotein CD8 alpha chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
hsa04660  T cell receptor signaling pathway
hsa05135  Yersinia infection
hsa05340  Primary immunodeficiency
Network
nt06120  Calcium signaling (viruses)
  Element
N01106  TCR-NFAT signaling pathway
Disease
H00093  Combined immunodeficiency
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Tucidinostat: D10993
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    925 (CD8A)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    925 (CD8A)
   04612 Antigen processing and presentation
    925 (CD8A)
   04660 T cell receptor signaling pathway
    925 (CD8A)
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    925 (CD8A)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    925 (CD8A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    925 (CD8A)
CD molecules [BR:hsa04090]
 Proteins
  925 (CD8A)
SSDB
Motif
Pfam: V-set Ig_3 I-set ig Ig_2
Other DBs
NCBI-GeneID: 925
NCBI-ProteinID: NP_001139345
OMIM: 186910
HGNC: 1706
Ensembl: ENSG00000153563
Vega: OTTHUMG00000130265
Pharos: P01732(Tbio)
UniProt: P01732 Q8TAW8 Q6ZVS2
LinkDB
Structure
PDB: 
2HP4 1CD8 1AKJ 3QZW

Position
2p11.2
AA seq 235 aa
MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQP
RGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSN
SIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFA
CDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV
NT seq 708 nt   +upstreamnt  +downstreamnt
atggccttaccagtgaccgccttgctcctgccgctggccttgctgctccacgccgccagg
ccgagccagttccgggtgtcgccgctggatcggacctggaacctgggcgagacagtggag
ctgaagtgccaggtgctgctgtccaacccgacgtcgggctgctcgtggctcttccagccg
cgcggcgccgccgccagtcccaccttcctcctatacctctcccaaaacaagcccaaggcg
gccgaggggctggacacccagcggttctcgggcaagaggttgggggacaccttcgtcctc
accctgagcgacttccgccgagagaacgagggctactatttctgctcggccctgagcaac
tccatcatgtacttcagccacttcgtgccggtcttcctgccagcgaagcccaccacgacg
ccagcgccgcgaccaccaacaccggcgcccaccatcgcgtcgcagcccctgtccctgcgc
ccagaggcgtgccggccagcggcggggggcgcagtgcacacgagggggctggacttcgcc
tgtgatatctacatctgggcgcccttggccgggacttgtggggtccttctcctgtcactg
gttatcaccctttactgcaaccacaggaaccgaagacgtgtttgcaaatgtccccggcct
gtggtcaaatcgggagacaagcccagcctttcggcgagatacgtctaa

KEGG   Homo sapiens (human): 926
Entry
926               CDS       T01001                                 

Gene name
CD8B, CD8B1, LEU2, LY3, LYT3, P37
Definition
(RefSeq) CD8b molecule
  KO
K06459  T-cell surface glycoprotein CD8 beta chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
hsa04660  T cell receptor signaling pathway
hsa05135  Yersinia infection
hsa05340  Primary immunodeficiency
Network
nt06120  Calcium signaling (viruses)
  Element
N01106  TCR-NFAT signaling pathway
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Tucidinostat: D10993
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    926 (CD8B)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    926 (CD8B)
   04612 Antigen processing and presentation
    926 (CD8B)
   04660 T cell receptor signaling pathway
    926 (CD8B)
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    926 (CD8B)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    926 (CD8B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    926 (CD8B)
CD molecules [BR:hsa04090]
 Proteins
  926 (CD8B)
SSDB
Motif
Pfam: V-set Ig_3 I-set ig Ig_2 Herpes_gE Ig_6
Other DBs
NCBI-GeneID: 926
NCBI-ProteinID: NP_004922
OMIM: 186730
HGNC: 1707
Ensembl: ENSG00000172116
Vega: OTTHUMG00000130264
Pharos: P10966(Tbio)
UniProt: P10966
LinkDB
Position
2p11.2
AA seq 210 aa
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQA
PSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVG
SPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGV
LVLLVSLGVAIHLCCRRRRARLRFMKQFYK
NT seq 633 nt   +upstreamnt  +downstreamnt
atgcggccgcggctgtggctcctcttggccgcgcagctgacagttctccatggcaactca
gtcctccagcagacccctgcatacataaaggtgcaaaccaacaagatggtgatgctgtcc
tgcgaggctaaaatctccctcagtaacatgcgcatctactggctgagacagcgccaggca
ccgagcagtgacagtcaccacgagttcctggccctctgggattccgcaaaagggactatc
cacggtgaagaggtggaacaggagaagatagctgtgtttcgggatgcaagccggttcatt
ctcaatctcacaagcgtgaagccggaagacagtggcatctacttctgcatgatcgtcggg
agccccgagctgaccttcgggaagggaactcagctgagtgtggttgatttccttcccacc
actgcccagcccaccaagaagtccaccctcaagaagagagtgtgccggttacccaggcca
gagacccagaagggcccactttgtagccccatcacccttggcctgctggtggctggcgtc
ctggttctgctggtttccctgggagtggccatccacctgtgctgccggcggaggagagcc
cggcttcgtttcatgaaacaattttacaaatga

KEGG   Homo sapiens (human): 927
Entry
927               CDS       T01001                                 

Gene name
CD8B2, CD8BP
Definition
(RefSeq) CD8b2 molecule
  KO
K06459  T-cell surface glycoprotein CD8 beta chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
hsa04660  T cell receptor signaling pathway
hsa05135  Yersinia infection
hsa05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    927 (CD8B2)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    927 (CD8B2)
   04612 Antigen processing and presentation
    927 (CD8B2)
   04660 T cell receptor signaling pathway
    927 (CD8B2)
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    927 (CD8B2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    927 (CD8B2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    927 (CD8B2)
CD molecules [BR:hsa04090]
 Proteins
  927 (CD8B2)
SSDB
Motif
Pfam: V-set Ig_3 ig I-set Ig_2 Herpes_gE Ig_6
Other DBs
NCBI-GeneID: 927
NCBI-ProteinID: NP_001336656
HGNC: 1708
Ensembl: ENSG00000254126
LinkDB
Position
2q12.2
AA seq 210 aa
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMCIYWLRQRQA
PSSDSHHEFLTLWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVG
SPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPVTLGLLVAGV
LVLLVSLGVAMHLCCRRRRARLRFMKQFYK
NT seq 633 nt   +upstreamnt  +downstreamnt
atgcggccgcggctgtggctcctcctggccgcgcagctgacagttctccatggcaactca
gtcctccagcagacccctgcatacataaaggtgcaaaccaacaagatggtgatgctgtcc
tgcgaggctaaaatctccctcagtaacatgtgcatctactggctgagacagcgccaggcc
ccgagcagtgatagtcaccacgagttcctgaccctctgggattccgcaaaagggactatc
cacggtgaagaggtggaacaggagaagatagctgtgtttcgggatgcaagccggttcatt
ctcaatctcacaagcgtgaagccggaggacagtggcatctacttctgcatgatcgtcggg
agccccgagctgaccttcgggaagggaactcagctgagtgtggttgatttccttcccacc
actgcccagcccaccaagaagtccaccctcaagaagagagtgtgccggttacccaggcca
gagacccagaagggcccactttgtagccccgtcacccttggcctgctggtggctggcgtc
ctggttctgctggtttccctgggagtggccatgcacctgtgctgccggcggaggagagcc
cggcttcgtttcatgaaacaattttacaaatga

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