Homo sapiens (human): 9971
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Entry
9971 CDS
T01001
Symbol
NR1H4, BAR, FXR, HRR-1, HRR1, PFIC5, RIP14
Name
(RefSeq) nuclear receptor subfamily 1 group H member 4
KO
K08537
farnesoid X receptor
Organism
hsa
Homo sapiens (human)
Pathway
hsa04976
Bile secretion
Disease
H00624
Progressive familial intrahepatic cholestasis
Drug target
Chenodeoxycholic acid:
D00163
<JP/US>
Cholic acid:
D10699
<JP/US>
Obeticholic acid:
D09360
<US>
Tropifexor:
D11548
Turofexorate isopropyl:
D08277
Ursodeoxycholic acid:
D00734
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09154 Digestive system
04976 Bile secretion
9971 (NR1H4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
9971 (NR1H4)
09183 Protein families: signaling and cellular processes
03310 Nuclear receptors [BR:
hsa03310
]
9971 (NR1H4)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 thyroid hormone receptor-like
9971 (NR1H4)
Nuclear receptors [BR:
hsa03310
]
1. Thyroid hormone like
1H. Liver X receptor like receptor
9971 (NR1H4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
zf-C4
Hormone_recep
Motif
Other DBs
NCBI-GeneID:
9971
NCBI-ProteinID:
NP_001193922
OMIM:
603826
HGNC:
7967
Ensembl:
ENSG00000012504
Pharos:
Q96RI1
(Tclin)
UniProt:
Q96RI1
Structure
PDB
LinkDB
All DBs
Position
12:100473866..100564414
Genome browser
AA seq
486 aa
AA seq
DB search
MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
NT seq
1461 nt
NT seq
+upstream
nt +downstream
nt
atggtaatgcagtttcaggggttagaaaatccaattcaaattagtcctcactgcagctgt
acgccgtcaggatttttcatggaaatgatgagtatgaagcccgcgaaaggtgttttaaca
gaacaagtggcaggtcctctgggacagaacctggaagtggaaccatactcgcaatacagc
aatgttcagtttccccaagttcaaccacagatttcctcgtcatcctattattccaacctg
ggtttctacccccagcagcctgaagagtggtactctcctggaatatatgaactcaggcgt
atgccagctgagactctctaccagggagaaactgaggtagcagagatgcctgtaacaaag
aagccccgcatgggcgcgtcagcagggaggatcaaaggggatgagctgtgtgttgtttgt
ggagacagagcctctggataccactataatgcactgacctgtgaggggtgtaaaggtttc
ttcaggagaagcattaccaaaaacgctgtgtacaagtgtaaaaacgggggcaactgtgtg
atggatatgtacatgcgaagaaagtgtcaagagtgtcgactaaggaaatgcaaagagatg
ggaatgttggctgaatgtatgtatacaggcttgttaactgaaattcagtgtaaatctaag
cgactgagaaaaaatgtgaagcagcatgcagatcagaccgtgaatgaagacagtgaaggt
cgtgacttgcgacaagtgacctcgacaacaaagtcatgcagggagaaaactgaactcacc
ccagatcaacagactcttctacattttattatggattcatataacaaacagaggatgcct
caggaaataacaaataaaattttaaaagaagaattcagtgcagaagaaaattttctcatt
ttgacggaaatggcaaccaatcatgtacaggttcttgtagaattcacaaaaaagctacca
ggatttcagactttggaccatgaagaccagattgctttgctgaaagggtctgcggttgaa
gctatgttccttcgttcagctgagattttcaataagaaacttccgtctgggcattctgac
ctattggaagaaagaattcgaaatagtggtatctctgatgaatatataacacctatgttt
agtttttataaaagtattggggaactgaaaatgactcaagaggagtatgctctgcttaca
gcaattgttatcctgtctccagatagacaatacataaaggatagagaggcagtagagaag
cttcaggagccacttcttgatgtgctacaaaagttgtgtaagattcaccagcctgaaaat
cctcaacactttgcctgtctcctgggtcgcctgactgaattacggacattcaatcatcac
cacgctgagatgctgatgtcatggagagtaaacgaccacaagtttaccccacttctctgt
gaaatctgggacgtgcagtga
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