KEGG   VARIANT: 1956v2Help
Entry
1956v2                      Variant                                

Name
EGFR mutation in non-small cell lung cancer
Gene
EGFR  epidermal growth factor receptor [KO:K04361]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
exon 19 deletion
Variation
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06266  Non-small cell lung cancer
  Element
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N10005  First/second-generation tyrosine kinase inhibitor to EGFR mutation
Reference
  Authors
Toyooka S, Mitsudomi T, Soh J, Aokage K, Yamane M, Oto T, Kiura K, Miyoshi S
  Title
Molecular oncology of lung cancer.
  Journal
Gen Thorac Cardiovasc Surg 59:527-37 (2011)
DOI:10.1007/s11748-010-0743-3
Reference
  Authors
Lee DH
  Title
Treatments for EGFR-mutant non-small cell lung cancer (NSCLC): The road to a success, paved with failures.
  Journal
Pharmacol Ther 174:1-21 (2017)
DOI:10.1016/j.pharmthera.2017.02.001
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