KEGG   VARIANT: 2064v1
Entry
2064v1                      Variant                                

Name
ERBB2 overexpression
Gene
ERBB2  erb-b2 receptor tyrosine kinase 2 [KO:K05083]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06219  JAK-STAT signaling
nt06262  Pancreatic cancer
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06270  Breast cancer
  Element
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00095  ERBB2-overexpression to EGF-Jak-STAT signaling pathway
N10009  Tyrosine kinase inhibitor to HER2 overexpression/amplification
Drug target
Lapatinib (DG00715): D04024<JP/US>
Neratinib (DG02303): D10898<US>
Pertuzumab: D05446<JP/US>
Trastuzumab: D03257<JP/US>
Trastuzumab deruxtecan: D11529<JP/US>
Trastuzumab emtansine: D09980<JP/US>
Reference
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
  Authors
Ingvarsson S.
  Title
Molecular genetics of breast cancer progression.
  Journal
Semin Cancer Biol 9:277-88 (1999)
DOI:10.1006/scbi.1999.0124
Reference
  Authors
Kenemans P, Verstraeten RA, Verheijen RH.
  Title
Oncogenic pathways in hereditary and sporadic breast cancer.
  Journal
Maturitas 49:34-43 (2004)
DOI:10.1016/j.maturitas.2004.06.005
Reference
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
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