KEGG   VARIANT: 2069v1Help
Entry
2069v1                      Variant                                

Name
EREG overexpression
Gene
EREG  epiregulin [KO:K09784]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06260  Colorectal cancer
  Element
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
Reference
  Authors
Di Fiore F, Sesboue R, Michel P, Sabourin JC, Frebourg T
  Title
Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer.
  Journal
Br J Cancer 103:1765-72 (2010)
DOI:10.1038/sj.bjc.6606008
Reference
  Authors
Jing C, Jin YH, You Z, Qiong Q, Jun Z
  Title
Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients.
  Journal
Oncotarget 7:55890-55899 (2016)
DOI:10.18632/oncotarget.10151
Reference
  Authors
Li XD, Miao SY, Wang GL, Yang L, Shu YQ, Yin YM
  Title
Amphiregulin and epiregulin expression in colorectal carcinoma and the correlation with clinicopathological characteristics.
  Journal
Onkologie 33:353-8 (2010)
DOI:10.1159/000315380
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