KEGG   VARIANT: 2260v1Help
Entry
2260v1                      Variant                                

Name
FGFR1 amplification
Gene
FGFR1  fibroblast growth factor receptor 1 [KO:K04362]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 59782
dbVar: nsv532311
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06261  Gastric cancer
nt06270  Breast cancer
  Element
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
Reference
  Authors
Dienstmann R, Rodon J, Prat A, Perez-Garcia J, Adamo B, Felip E, Cortes J, Iafrate AJ, Nuciforo P, Tabernero J
  Title
Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors.
  Journal
Ann Oncol 25:552-63 (2014)
DOI:10.1093/annonc/mdt419
Reference
  Authors
Turner N, Pearson A, Sharpe R, Lambros M, Geyer F, Lopez-Garcia MA, Natrajan R, Marchio C, Iorns E, Mackay A, Gillett C, Grigoriadis A, Tutt A, Reis-Filho JS, Ashworth A
  Title
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer.
  Journal
Cancer Res 70:2085-94 (2010)
DOI:10.1158/0008-5472.CAN-09-3746
LinkDB All DBs

KEGG   VARIANT: 2263v1Help
Entry
2263v1                      Variant                                

Name
FGFR2 amplification
Gene
FGFR2  fibroblast growth factor receptor 2 [KO:K05093]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 396706 153718 148679
dbVar: nsv2774502 nsv995712 nsv868923
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06261  Gastric cancer
nt06270  Breast cancer
  Element
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
Reference
PMID:2377625
  Authors
Hattori Y, Odagiri H, Nakatani H, Miyagawa K, Naito K, Sakamoto H, Katoh O, Yoshida T, Sugimura T, Terada M
  Title
K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.
  Journal
Proc Natl Acad Sci U S A 87:5983-7 (1990)
DOI:10.1073/pnas.87.15.5983
Reference
  Authors
Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C
  Title
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.
  Journal
Oncotarget 6:24750-79 (2015)
DOI:10.18632/oncotarget.4990
Reference
  Authors
Vauhkonen M, Vauhkonen H, Sipponen P
  Title
Pathology and molecular biology of gastric cancer.
  Journal
Best Pract Res Clin Gastroenterol 20:651-74 (2006)
DOI:10.1016/j.bpg.2006.03.016
Reference
  Authors
Katoh M, Nakagama H
  Title
FGF receptors: cancer biology and therapeutics.
  Journal
Med Res Rev 34:280-300 (2014)
DOI:10.1002/med.21288
LinkDB All DBs

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