KEGG   VARIANT: 25v2Help
Entry
25v2                      Variant                                  

Name
First generation TKI-resistant ABL1 mutation
Gene
ABL1  ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation T315I
ClinVar: 12624
dbSNP: rs121913456
COSM: 12614 12560
Variation
mutation Y253H
ClinVar: 12627
dbSNP: rs121913461
COSM: 12576
Variation
mutation E255K
ClinVar: 12626
dbSNP: rs387906517
COSM: 12573
Variation
mutation E255V
ClinVar: 12625
dbSNP: rs387906516
COSM: 12574
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06219  JAK-STAT signaling
nt06276  Chronic myeloid leukemia
  Element
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00055  BCR-ABL fusion kinase to Jak-STAT signaling pathway
N10002  Second/third-generation tyrosine kinase inhibitor to BCR-ABL fusion
Reference
  Authors
O'Hare T, Eide CA, Deininger MW
  Title
Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia.
  Journal
Blood 110:2242-9 (2007)
DOI:10.1182/blood-2007-03-066936
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