KEGG   VARIANT: 3195v1Help
Entry
3195v1                      Variant                                

Name
TLX1 rearrangemnet
Gene
TLX1  T cell leukemia homeobox 1 [KO:K09340]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
translocation t(10;14)(q24;q11)
Variation
translocation t(7;10)(q35;q24)
Network
nt06240  Transcription
  Element
N00144  TLX1 rearrangement to transcriptional repression
Reference
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
  Authors
Larmonie NS, Dik WA, Meijerink JP, Homminga I, van Dongen JJ, Langerak AW
  Title
Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia.
  Journal
Haematologica 98:1173-84 (2013)
DOI:10.3324/haematol.2012.082156
Reference
  Authors
De Keersmaecker K, Ferrando AA
  Title
TLX1-induced T-cell acute lymphoblastic leukemia.
  Journal
Clin Cancer Res 17:6381-6 (2011)
DOI:10.1158/1078-0432.CCR-10-3037
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