KEGG   VARIANT: 367v2Help
Entry
367v2                      Variant                                 

Name
AR mutation
Gene
AR  androgen receptor [KO:K08557]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation L702H
ClinVar: 219296
dbSNP: rs864622007
COSM: 238553
Variation
mutation H875Y
ClinVar: 9834
dbSNP: rs13785281
COSM: 238555
Variation
mutation T878A
ClinVar: 9381
dbSNP: rs137852578
COSM: 236693
Variation
mutation P893S
COSM: 5563016
Variation
mutation Q903H
COSM: 5564006
Network
nt06227  NR signaling
nt06272  Prostate cancer
  Element
N00085  Mutation-activated AR to androgen receptor signaling pathway
Reference
  Authors
Beltran H, Yelensky R, Frampton GM, Park K, Downing SR, MacDonald TY, Jarosz M, Lipson D, Tagawa ST, Nanus DM, Stephens PJ, Mosquera JM, Cronin MT, Rubin MA
  Title
Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity.
  Journal
Eur Urol 63:920-6 (2013)
DOI:10.1016/j.eururo.2012.08.053
Reference
  Authors
Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G, Beltran H, Abida W, Bradley RK, Vinson J, Cao X, Vats P, Kunju LP, Hussain M, Feng FY, Tomlins SA, Cooney KA, Smith DC, Brennan C, Siddiqui J, Mehra R, Chen Y, Rathkopf DE, Morris MJ, Solomon SB, Durack JC, Reuter VE, Gopalan A, Gao J, Loda M, Lis RT, Bowden M, Balk SP, Gaviola G, Sougnez C, Gupta M, Yu EY, Mostaghel EA, Cheng HH, Mulcahy H, True LD, Plymate SR, Dvinge H, Ferraldeschi R, Flohr P, Miranda S, Zafeiriou Z, Tunariu N, Mateo J, Perez-Lopez R, Demichelis F, Robinson BD, Schiffman M, Nanus DM, Tagawa ST, Sigaras A, Eng KW, Elemento O, Sboner A, Heath EI, Scher HI, Pienta KJ, Kantoff P, de Bono JS, Rubin MA, Nelson PS, Garraway LA, Sawyers CL, Chinnaiyan AM
  Title
Integrative clinical genomics of advanced prostate cancer.
  Journal
Cell 161:1215-28 (2015)
DOI:10.1016/j.cell.2015.05.001
LinkDB All DBs

DBGET integrated database retrieval system