MET  MET proto-oncogene, receptor tyrosine kinase [KO:K05099]

hsa_var Human gene variants (Homo sapiens)

mutation V1110I
Clinvar: 186141
dbSNP: rs5030821
COSM: 3724572

mutation H1112Y
Clinvar: 376068
dbSNP: rs121913244
COSM: 696

mutation M1149T
Clinvar: 13881
dbSNP: rs121913668
COSM: 704

mutation V1206L
Clinvar: 13882
dbSNP: rs121913669
COSM: 3724576 5015793

mutation L1213V
Clinvar: 13886
dbSNP: rs121913673
COSM: 688

mutation V1238I
Clinvar: 13883
dbSNP: rs121913670
COSM: 1673476

mutation D1246H
ClinVar: 376728
dbSNP: rs121913671
COSM: 689

mutation M1268T
ClinVar: 376126
dbSNP: rs121913245
COSM: 691

mutation T1191I
ClinVar: 13888
dbSNP: rs121913675
COSM: 693

mutation M1268I
ClinVar: 13889
dbSNP: rs121913676
COSM: 694

mutation K1262R
ClinVar: 13890
dbSNP: rs121913677
COSM: 695

mutation H1112L
COSM: 698

mutation H1124D
COSM: 697

nt06210  ERK signaling
nt06214  PI3K signaling
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma

PMID:10327054

Schmidt L, Junker K, Nakaigawa N, Kinjerski T, Weirich G, Miller M, Lubensky I, Neumann HP, Brauch H, Decker J, Vocke C, Brown JA, Jenkins R, Richard S, Bergerheim U, Gerrard B, Dean M, Linehan WM, Zbar B

Novel mutations of the MET proto-oncogene in papillary renal carcinomas.

Oncogene 18:2343-50 (1999)
DOI:10.1038/sj.onc.1202547

PMID:9927037

Park WS, Dong SM, Kim SY, Na EY, Shin MS, Pi JH, Kim BJ, Bae JH, Hong YK, Lee KS, Lee SH, Yoo NJ, Jang JJ, Pack S, Zhuang Z, Schmidt L, Zbar B, Lee JY

Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.

Cancer Res 59:307-10 (1999)