KEGG   VARIANT: 4233v3Help
Entry
4233v3                      Variant                                

Name
MET amplification
Gene
MET  MET proto-oncogene, receptor tyrosine kinase [KO:K05099]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 59715
dbVar: nsv532243
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06261  Gastric cancer
  Element
N00259  Amplified MET to RAS-ERK signaling pathway
N00260  Amplified MET to PI3K signaling pathway
Reference
  Authors
Kawakami H, Okamoto I, Okamoto W, Tanizaki J, Nakagawa K, Nishio K
  Title
Targeting MET Amplification as a New Oncogenic Driver.
  Journal
Cancers (Basel) 6:1540-52 (2014)
DOI:10.3390/cancers6031540
Reference
  Authors
Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C
  Title
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.
  Journal
Oncotarget 6:24750-79 (2015)
DOI:10.18632/oncotarget.4990
Reference
  Authors
Panani AD
  Title
Cytogenetic and molecular aspects of gastric cancer: clinical implications.
  Journal
Cancer Lett 266:99-115 (2008)
DOI:10.1016/j.canlet.2008.02.053
Reference
  Authors
Vauhkonen M, Vauhkonen H, Sipponen P
  Title
Pathology and molecular biology of gastric cancer.
  Journal
Best Pract Res Clin Gastroenterol 20:651-74 (2006)
DOI:10.1016/j.bpg.2006.03.016
LinkDB All DBs

DBGET integrated database retrieval system