KEGG   VARIANT: 4233v4
Entry
4233v4                      Variant                                

Name
MET exon 14 skipping
Gene
MET  MET proto-oncogene, receptor tyrosine kinase [KO:K05099]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation D1028N
COSM: 6056852
Variation
mutation c.3028+1G>T
COSM: 6108462
Variation
deletion c.3025_3028+3del
COSM: 6965225
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06266  Non-small cell lung cancer
  Element
N01062  Mutation-activated MET to RAS-ERK signaling pathway
N01063  Mutation-activated MET to PI3K signaling pathway
N10024  Tyrosine kinase inhibitor to MET exon 14 skipping
Reference
  Authors
Mahjoubi L, Gazzah A, Besse B, Lacroix L, Soria JC
  Title
A never-smoker lung adenocarcinoma patient with a MET exon 14 mutation (D1028N) and a rapid partial response after crizotinib.
  Journal
Invest New Drugs 34:397-8 (2016)
DOI:10.1007/s10637-016-0332-0
Reference
  Authors
Frampton GM, Ali SM, Rosenzweig M, Chmielecki J, Lu X, Bauer TM, Akimov M, Bufill JA, Lee C, Jentz D, Hoover R, Ou SH, Salgia R, Brennan T, Chalmers ZR, Jaeger S, Huang A, Elvin JA, Erlich R, Fichtenholtz A, Gowen KA, Greenbowe J, Johnson A, Khaira D, McMahon C, Sanford EM, Roels S, White J, Greshock J, Schlegel R, Lipson D, Yelensky R, Morosini D, Ross JS, Collisson E, Peters M, Stephens PJ, Miller VA
  Title
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.
  Journal
Cancer Discov 5:850-9 (2015)
DOI:10.1158/2159-8290.CD-15-0285
Reference
  Authors
Li Y, Gao L, Ma D, Qiu T, Li W, Li W, Guo L, Xing P, Liu B, Deng L, Fu J, Li J, Yu Y, Ying J
  Title
Identification of MET exon14 skipping by targeted DNA- and RNA-based next-generation sequencing in pulmonary sarcomatoid carcinomas.
  Journal
Lung Cancer 122:113-119 (2018)
DOI:10.1016/j.lungcan.2018.06.001
Reference
  Authors
Reungwetwattana T, Liang Y, Zhu V, Ou SI
  Title
The race to target MET exon 14 skipping alterations in non-small cell lung cancer: The Why, the How, the Who, the Unknown, and the Inevitable.
  Journal
Lung Cancer 103:27-37 (2017)
DOI:10.1016/j.lungcan.2016.11.011
Reference
  Authors
Pasquini G, Giaccone G
  Title
C-MET inhibitors for advanced non-small cell lung cancer.
  Journal
Expert Opin Investig Drugs 27:363-375 (2018)
DOI:10.1080/13543784.2018.1462336
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