VARIANT: 4609v1
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Entry
4609v1 Variant
Name
MYC amplification
Gene
MYC
MYC proto-oncogene, bHLH transcription factor [KO:
K04377
]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar:
160870
394884
153231
151754
149554
dbVar:
nsv1067711
nsv2774782
nsv995229
nsv931643
nsv915813
Network
nt06230
Cell cycle G1/S
nt06267
Small cell lung cancer
Element
N00088
Amplified MYC to p15-cell cycle G1/S
N00089
Amplified MYC to cell cycle G1/S
N00092
Amplified MYC to p27-cell cycle G1/S
Reference
PMID:
9508209
Authors
Salgia R, Skarin AT
Title
Molecular abnormalities in lung cancer.
Journal
J Clin Oncol 16:1207-17 (1998)
DOI:
10.1200/JCO.1998.16.3.1207
Reference
PMID:
12379883
Authors
Osada H, Takahashi T.
Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
Journal
Oncogene 21:7421-34 (2002)
DOI:
10.1038/sj.onc.1205802
Reference
PMID:
15769940
Authors
Meuwissen R, Berns A.
Title
Mouse models for human lung cancer.
Journal
Genes Dev 19:643-64 (2005)
DOI:
10.1101/gad.1284505
LinkDB
All DBs
Homo sapiens (human): 4149
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Entry
4149 CDS
T01001
Gene name
MAX, bHLHd4
Definition
(RefSeq) MYC associated factor X
KO
K04453
Max protein
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05222
Small cell lung cancer
Network
nt06130
Cell cycle (viruses)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06230
Cell cycle G1/S
nt06240
Transcription
nt06267
Small cell lung cancer
Element
N00088
Amplified MYC to p15-cell cycle G1/S
N00089
Amplified MYC to cell cycle G1/S
N00090
p15-Cell cycle G1/S
N00092
Amplified MYC to p27-cell cycle G1/S
N00131
Amplified MYCN to transcriptional activation
N00132
Amplified MYCN to transcriptional repression
Disease
H01510
Malignant paraganglioma
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
4149 (MAX)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4149 (MAX)
05202 Transcriptional misregulation in cancer
4149 (MAX)
09162 Cancer: specific types
05222 Small cell lung cancer
4149 (MAX)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
4149 (MAX)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
Cell cycle controlling factors, Mad/Max
4149 (MAX)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
HLH
DUF5716
Filament
SlyX
Jnk-SapK_ap_N
bZIP_2
DUF5595
ZapB
DUF4763
Csm1_N
ATG16
V_ATPase_I
Motif
Other DBs
NCBI-GeneID:
4149
NCBI-ProteinID:
NP_002373
OMIM:
154950
HGNC:
6913
Ensembl:
ENSG00000125952
Vega:
OTTHUMG00000142809
Pharos:
P61244
(Tbio)
UniProt:
P61244
Q8TAX8
LinkDB
All DBs
Structure
PDB:
6G6K
1NKP
1NLW
6G6L
6G6J
5EYO
1HLO
1R05
Thumbnails
Position
14q23.3
AA seq
160 aa
AA seq
DB search
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASR
AQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDN
SLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
NT seq
483 nt
NT seq
+upstream
nt +downstream
nt
atgagcgataacgatgacatcgaggtggagagcgacgaagagcaaccgaggtttcaatct
gcggctgacaaacgggctcatcataatgcactggaacgaaaacgtagggaccacatcaaa
gacagctttcacagtttgcgggactcagtcccatcactccaaggagagaaggcatcccgg
gcccaaatcctagacaaagccacagaatatatccagtatatgcgaaggaaaaaccacaca
caccagcaagatattgacgacctcaagcggcagaatgctcttctggagcagcaagtccgt
gcactggagaaggcgaggtcaagtgcccaactgcagaccaactacccctcctcagacaac
agcctctacaccaacgccaagggcagcaccatctctgccttcgatgggggctcggactcc
agctcggagtctgagcctgaagagccccaaagcaggaagaagctccggatggaggccagc
taa
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integrated database retrieval system