KEGG   VARIANT: 4609v1
Entry
4609v1                      Variant                                

Name
MYC amplification
Gene
MYC  MYC proto-oncogene, bHLH transcription factor [KO:K04377]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
Network
nt06230  Cell cycle G1/S
nt06267  Small cell lung cancer
  Element
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
Reference
PMID:9508209
  Authors
Salgia R, Skarin AT
  Title
Molecular abnormalities in lung cancer.
  Journal
J Clin Oncol 16:1207-17 (1998)
DOI:10.1200/JCO.1998.16.3.1207
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
  Authors
Meuwissen R, Berns A.
  Title
Mouse models for human lung cancer.
  Journal
Genes Dev 19:643-64 (2005)
DOI:10.1101/gad.1284505
LinkDB

KEGG   Homo sapiens (human): 4149
Entry
4149              CDS       T01001                                 

Gene name
MAX, bHLHd4
Definition
(RefSeq) MYC associated factor X
  KO
K04453  Max protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05222  Small cell lung cancer
Network
nt06130  Cell cycle (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06230  Cell cycle G1/S
nt06240  Transcription
nt06267  Small cell lung cancer
  Element
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00131  Amplified MYCN to transcriptional activation
N00132  Amplified MYCN to transcriptional repression
Disease
H01510  Malignant paraganglioma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4149 (MAX)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4149 (MAX)
   05202 Transcriptional misregulation in cancer
    4149 (MAX)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    4149 (MAX)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    4149 (MAX)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
   Cell cycle controlling factors, Mad/Max
    4149 (MAX)
SSDB
Motif
Pfam: HLH DUF5716 Filament SlyX Jnk-SapK_ap_N bZIP_2 DUF5595 ZapB DUF4763 Csm1_N ATG16 V_ATPase_I
Other DBs
NCBI-GeneID: 4149
NCBI-ProteinID: NP_002373
OMIM: 154950
HGNC: 6913
Ensembl: ENSG00000125952
Vega: OTTHUMG00000142809
Pharos: P61244(Tbio)
UniProt: P61244 Q8TAX8
LinkDB
Structure
PDB: 

Position
14q23.3
AA seq 160 aa
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASR
AQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDN
SLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
NT seq 483 nt   +upstreamnt  +downstreamnt
atgagcgataacgatgacatcgaggtggagagcgacgaagagcaaccgaggtttcaatct
gcggctgacaaacgggctcatcataatgcactggaacgaaaacgtagggaccacatcaaa
gacagctttcacagtttgcgggactcagtcccatcactccaaggagagaaggcatcccgg
gcccaaatcctagacaaagccacagaatatatccagtatatgcgaaggaaaaaccacaca
caccagcaagatattgacgacctcaagcggcagaatgctcttctggagcagcaagtccgt
gcactggagaaggcgaggtcaagtgcccaactgcagaccaactacccctcctcagacaac
agcctctacaccaacgccaagggcagcaccatctctgccttcgatgggggctcggactcc
agctcggagtctgagcctgaagagccccaaagcaggaagaagctccggatggaggccagc
taa

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