KEGG   VARIANT: 6098v1
Entry
6098v1                      Variant                                

Name
ROS1 fusion
Gene
ROS1  ROS proto-oncogene 1, receptor tyrosine kinase [KO:K05088]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
CD74-ROS1 fusion caused by translocation t(5;6)(q32;q22)
COSF: 1201
Variation
SLC34A2-ROS1 fusion caused by translocation t(4;6)(Q15.2;q22)
COSF: 1197
Network
  Element
N10003  First-generation tyrosine kinase inhibitor to ALK fusion
Drug target
Crizotinib: D09731<JP/US>
Entrectinib: D10926<JP/US>
Reference
  Authors
Matsuura S, Shinmura K, Kamo T, Igarashi H, Maruyama K, Tajima M, Ogawa H, Tanahashi M, Niwa H, Funai K, Kohno T, Suda T, Sugimura H
  Title
CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma.
  Journal
Oncol Rep 30:1675-80 (2013)
DOI:10.3892/or.2013.2630
Reference
  Authors
Rossi G, Jocolle G, Conti A, Tiseo M, Zito Marino F, Donati G, Franco R, Bono F, Barbisan F, Facchinetti F
  Title
Detection of ROS1 rearrangement in non-small cell lung cancer: current and future perspectives.
  Journal
Lung Cancer (Auckl) 8:45-55 (2017)
DOI:10.2147/LCTT.S120172
Reference
  Authors
Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, Asaka R, Hamanaka W, Ninomiya H, Uehara H, Lim Choi Y, Satoh Y, Okumura S, Nakagawa K, Mano H, Ishikawa Y
  Title
RET, ROS1 and ALK fusions in lung cancer.
  Journal
Nat Med 18:378-81 (2012)
DOI:10.1038/nm.2658
Reference
  Authors
Davies KD, Doebele RC
  Title
Molecular pathways: ROS1 fusion proteins in cancer.
  Journal
Clin Cancer Res 19:4040-5 (2013)
DOI:10.1158/1078-0432.CCR-12-2851
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