KEGG   VARIANT: 861v1Help
Entry
861v1                      Variant                                 

Name
AML1-EVI1 fusion
Gene
RUNX1  RUNX family transcription factor 1 [KO:K08367]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
translocation t(3;21)(q26;q22)
Network
nt06218  TGFB signaling
nt06276  Chronic myeloid leukemia
  Element
N00106  AML1-EVI1 fusion to TGF-beta signaling pathway
Reference
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
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