KEGG   VARIANT: 861v2Help
Entry
861v2                      Variant                                 

Name
AML1-ETO fusion
Gene
RUNX1  RUNX family transcription factor 1 [KO:K08367]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
translocation t(8;21)(q22;q22)
Network
nt06240  Transcription
nt06275  Acute myeloid leukemia
  Element
N00108  AML1-ETO fusion to transcriptional activtion
N00111  AML1-ETO fusion to CEBPA-mediated transcription
N00112  AML1-ETO fusion to PU.1-mediated transcription
Reference
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
  Authors
Saultz JN, Garzon R
  Title
Acute Myeloid Leukemia: A Concise Review.
  Journal
J Clin Med 5:E33 (2016)
DOI:10.3390/jcm5030033
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