KEGG   VARIANT: 861v4Help
Entry
861v4                      Variant                                 

Name
TEL-AML1 fusion
Gene
RUNX1  RUNX family transcription factor 1 [KO:K08367]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
translocation t(12;21)(p12;q22)
COSF: 2246 2258 2248
Variation
translocation t(12;21)(p13;q22)
COSF: 2246 2258 2248
Network
nt06240  Transcription
  Element
N00118  TEL-AML1 fusion to transcriptional repression
Reference
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
  Authors
Morrow M, Samanta A, Kioussis D, Brady HJ, Williams O
  Title
TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL.
  Journal
Oncogene 26:4404-14 (2007)
DOI:10.1038/sj.onc.1210227
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