KEGG   ORTHOLOGY: K00235Help
Entry
K00235                      KO                                     

Name
SDHB, SDH2
Definition
succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00190  Oxidative phosphorylation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01200  Carbon metabolism
ko04714  Thermogenesis
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05016  Huntington disease
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00148  Succinate dehydrogenase (ubiquinone)
Disease
H01222  Cowden syndrome
H01510  Malignant paraganglioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05010 Alzheimer disease
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
   05012 Parkinson disease
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
   05016 Huntington disease
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
  09166 Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00009  Citrate cycle (TCA cycle, Krebs cycle)
     K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
    M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
     K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
 Structural complex
  Energy metabolism
   ATP synthesis
    M00148  Succinate dehydrogenase (ubiquinone)
     K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.1  succinate dehydrogenase
     K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
BRITE hierarchy
Other DBs
RN: R02164
COG: COG0479
GO: 0008177
Genes
HSA: 6390(SDHB)
PTR: 456526(SDHB)
PPS: 100989574(SDHB)
GGO: 101131972(SDHB)
PON: 100437700(SDHB)
NLE: 100582706(SDHB)
MCC: 699810(SDHB)
MCF: 101865119(SDHB)
CSAB: 103225507(SDHB)
RRO: 104669912(SDHB)
RBB: 108515327(SDHB)
CJC: 100403702(SDHB)
SBQ: 101044303(SDHB)
MMU: 67680(Sdhb)
RNO: 298596(Sdhb)
CGE: 100771246(Sdhb)
NGI: 103725310(Sdhb)
HGL: 101720891(Sdhb)
CCAN: 109689825(Sdhb)
OCU: 100328585(SDHB)
TUP: 102480936(SDHB)
CFA: 478217(SDHB)
AML: 100473290(SDHB)
UMR: 103666614(SDHB)
ORO: 101380075(SDHB)
FCA: 751617(SDHB)
PTG: 102961107(SDHB)
AJU: 106975612(SDHB)
BTA: 286840(SDHB)
BOM: 102274978(SDHB)
BIU: 109574556(SDHB)
PHD: 102315900(SDHB)
CHX: 102183195(SDHB)
OAS: 101108729(SDHB) 101110243
SSC: 414412(SDHB)
CFR: 102524547(SDHB)
CDK: 105107079(SDHB)
BACU: 103013798(SDHB)
LVE: 103078950(SDHB)
OOR: 101278085(SDHB)
ECB: 100050091(SDHB)
EPZ: 103540492(SDHB)
EAI: 106827983(SDHB)
MYB: 102242794 102254448(SDHB)
MYD: 102752857(SDHB) 102771621
HAI: 109389410(SDHB)
RSS: 109442979 109458977(SDHB)
PALE: 102894659(SDHB)
LAV: 100141376(SDHB)
TMU: 101353562
MDO: 751078(SDHB)
SHR: 100924299(SDHB)
OAA: 100074487(SDHB)
GGA: 100859720(SDHB)
MGP: 100543850(SDHB)
CJO: 107323469(SDHB)
APLA: 101793933(SDHB)
ACYG: 106040166(SDHB)
TGU: 100190642(SDHB)
GFR: 102037337(SDHB)
FAB: 101817512 101819204(SDHB)
PHI: 102114745(SDHB)
PMAJ: 107213507(SDHB)
FPG: 101918141(SDHB)
FCH: 102047150(SDHB)
CLV: 102091815
EGZ: 104133181(SDHB)
AAM: 106484668(SDHB)
ASN: 102373063(SDHB)
AMJ: 102575823(SDHB)
PSS: 102445790(SDHB)
CMY: 102940700(SDHB)
CPIC: 101939393(SDHB) 101949570
ACS: 100556555(sdhb)
PVT: 110073147(SDHB)
PBI: 103065195(SDHB)
GJA: 107111390(SDHB)
XLA: 108696840(sdhb.L) 379939(sdhb.S)
XTR: 100144957(sdhb)
NPR: 108803746(SDHB)
DRE: 562149(sdhb)
IPU: 100528601(sdhb)
AMEX: 103031341(sdhb)
TRU: 101072453(sdhb) 101075255
NCC: 104949017 104959019(sdhb)
NFU: 107385781(sdhb)
CSEM: 103385849(sdhb)
ELS: 105017105(sdhb)
LCM: 102358325(RCC2)
CMK: 103187447(sdhb)
CIN: 100181830
SPU: 589263
APLC: 110979126
SKO: 100369462
DME: Dmel_CG3283(SdhB) Dmel_CG7349(SdhBL)
DSI: Dsimw501_GD10425(Dsim_GD10425) Dsimw501_GD17417(Dsim_GD17417)
AAG: 5573238
AME: 551169(GB14832) 551917(GB17542) 727212
NVI: 100116862(SdhB) 100117703
TCA: 658066(SdhB) 663097
NVL: 108559005
API: 100162363(Sdhb)
DNX: 107169875
ZNE: 110826970
FCD: 110848850
TUT: 107366097
CEL: CELE_F42A8.2(sdhb-1)
CBR: CBG00872(Cbr-sdhb-1)
BMY: Bm1_17690
TSP: Tsp_09576
MYI: 110440487
OBI: 106881280
SHX: MS3_09457
ADF: 107333862
HMG: 100206520
AQU: 100632374
ATH: AT3G27380(SDH2-1) AT5G40650(SDH2-2) AT5G65165(SDH2-3)
VRA: 106762873
VAR: 108334450
CCAJ: 109812842
CAM: 101492705
LJA: Lj0g3v0336519.1(Lj0g3v0336519.1) Lj1g3v3740570.1(Lj1g3v3740570.1) Lj1g3v3751710.1(Lj1g3v3751710.1) Lj1g3v3751710.2(Lj1g3v3751710.2) Lj4g3v0485140.1(Lj4g3v0485140.1)
LANG: 109350651
CSV: 101209955 101220767(SDHB)
POP: 7456195
NNU: 104607007
DOSA: Os08t0120000-01(Os08g0120000) Os09t0370300-01(Os09g0370300)
ATS: 109762674(LOC109762674) 109763002(LOC109763002)
SITA: 101774368
DCT: 110102371
AOF: 109824390
PPP: 112289680
CRE: CHLREDRAFT_142231(SDH2)
VCN: VOLCADRAFT_78776(sdh2)
MNG: MNEG_7619
MIS: MICPUN_105014(SDH1)
SCE: YLL041C(SDH2)
ERC: Ecym_8411
KMX: KLMA_80408(SDH2)
NCS: NCAS_0A02980(NCAS0A02980) NCAS_0C05870(NCAS0C05870)
NDI: NDAI_0D04950(NDAI0D04950) NDAI_0H00250(NDAI0H00250)
TPF: TPHA_0F00210(TPHA0F00210)
TBL: TBLA_0E01400(TBLA0E01400)
TDL: TDEL_0G01780(TDEL0G01780)
KAF: KAFR_0L00230(KAFR0L00230)
PIC: PICST_50416(SDH2)
CAL: CAALFM_CR05180CA(SDH2)
CAUR: QG37_03977
SLB: AWJ20_2469(SDH2)
NCR: NCU00959(tca-10)
NTE: NEUTE1DRAFT118669(NEUTE1DRAFT_118669)
MGR: MGG_00167
MAW: MAC_09331
MAJ: MAA_03382
CMT: CCM_07146
BFU: BCIN_01g04980(Bcsdh2)
MBE: MBM_04777
ANI: AN2332.2
ANG: ANI_1_1422124(An14g04400)
ABE: ARB_02933
TVE: TRV_07643
PTE: PTT_14436
ZTR: MYCGRDRAFT_74146(SDH2)
SPO: SPAC140.01(sdh2)
CNE: CNG03480
CNB: CNBG1290
ABP: AGABI1DRAFT115047(SDH2)
ABV: AGABI2DRAFT195434(SDH2)
SLA: SERLADRAFT_478574(SDH2)
MGL: MGL_3104
DDI: DDB_G0270120(sdhB)
PYO: PY17X_1430900(PY04921)
PCB: PCHAS_143060(PC000220.05.0)
TAN: TA19430
TPV: TP01_0210
BBO: BBOV_IV005280(23.m06368)
SMIN: v1.2.008970.t1(symbB.v1.2.008970.t1) v1.2.020965.t1(symbB.v1.2.020965.t1)
PTI: PHATRDRAFT_52539(SDH2)
TPS: THAPSDRAFT_32945(SDH1)
SPAR: SPRG_14325
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2302193
  Authors
Kita K, Oya H, Gennis RB, Ackrell BA, Kasahara M
  Title
Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria.
  Journal
Biochem Biophys Res Commun 166:101-8 (1990)
DOI:10.1016/0006-291X(90)91916-G
  Sequence
[hsa:6390]
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