KEGG   ORTHOLOGY: K00907Help
Entry
K00907                      KO                                     

Name
MYLK
Definition
myosin-light-chain kinase [EC:2.7.11.18]
Pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04510  Focal adhesion
ko04611  Platelet activation
ko04810  Regulation of actin cytoskeleton
ko04921  Oxytocin signaling pathway
ko04971  Gastric acid secretion
Disease
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K00907  MYLK; myosin-light-chain kinase
   04020 Calcium signaling pathway
    K00907  MYLK; myosin-light-chain kinase
   04022 cGMP-PKG signaling pathway
    K00907  MYLK; myosin-light-chain kinase
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K00907  MYLK; myosin-light-chain kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K00907  MYLK; myosin-light-chain kinase
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K00907  MYLK; myosin-light-chain kinase
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K00907  MYLK; myosin-light-chain kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K00907  MYLK; myosin-light-chain kinase
  09154 Digestive system
   04971 Gastric acid secretion
    K00907  MYLK; myosin-light-chain kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K00907  MYLK; myosin-light-chain kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.18  myosin-light-chain kinase
     K00907  MYLK; myosin-light-chain kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  MLCK family
   K00907  MYLK; myosin-light-chain kinase
BRITE hierarchy
Other DBs
GO: 0004687
Genes
HSA: 340156(MYLK4) 4638(MYLK) 85366(MYLK2) 91807(MYLK3)
PTR: 101057233(MYLK) 465143(MYLK3) 471840(MYLK4) 742591(MYLK2)
PPS: 100974667(MYLK3) 100978891(MYLK2) 100979422(MYLK) 100995666(MYLK4)
GGO: 101142619(MYLK3) 101143745(MYLK2) 101151517(MYLK) 101151667(MYLK4)
PON: 100171951(MYLK3) 100444714(MYLK4) 100452913(MYLK) 100453783(MYLK2)
NLE: 100585981(MYLK2) 100591151(MYLK) 100594745(MYLK4) 100604194 115831086(MYLK3)
MCC: 707361(MYLK4) 712830(MYLK2) 715422(MYLK) 716132(MYLK3)
MCF: 102122026(MYLK4) 102130711(MYLK) 102132754(MYLK3) 102145766(MYLK2)
CSAB: 103222295(MYLK4) 103228167(MYLK) 103232215(MYLK3) 103248051(MYLK2)
RRO: 104653717(MYLK2) 104655407(MYLK) 104655430(MYLK3) 104661238(MYLK4)
RBB: 108514260(MYLK4) 108517416(MYLK) 108524142(MYLK2) 108534775(MYLK3)
CJC: 100391801(MYLK2) 100392653(MYLK3) 100392656(MYLK4) 100409440(MYLK)
SBQ: 101029220(MYLK) 101038668(MYLK2) 101049056(MYLK4) 101050910(MYLK3) 104653493
MMU: 107589(Mylk) 213435(Mylk3) 228785(Mylk2) 238564(Mylk4)
MCAL: 110290127(Mylk2) 110300419(Mylk3) 110308670(Mylk4) 110311174(Mylk)
MPAH: 110319274(Mylk2) 110329346(Mylk) 110334129(Mylk4) 110337577(Mylk3)
RNO: 100911165(Mylk4) 103689985 117558(Mylk2) 288057(Mylk) 291926(Mylk3)
MUN: 110547228(Mylk) 110550095(Mylk2) 110552995(Mylk3) 110558635(Mylk4)
CGE: 100755963(Mylk2) 100756400(Mylk4) 100758406(Mylk) 100766446(Mylk3)
NGI: 103731078(Mylk2) 103737011(Mylk4) 103741992(Mylk) 103745443(Mylk3)
HGL: 101697894(Mylk3) 101701713(Mylk4) 101704236(Mylk) 101712444(Mylk2)
CCAN: 109677703 109691764(Mylk2) 109700226(Mylk4) 109701077(Mylk) 109703135(Mylk3)
OCU: 100009051(MYLK2) 100009143(MYLK) 100348694(MYLK3) 100353972(MYLK4)
TUP: 102468205(MYLK3) 102476504(MYLK) 102489117(MYLK2) 102498032(MYLK4)
CFA: 475345(MYLK3) 477187(MYLK2) 488012(MYLK) 488190(MYLK4)
VVP: 112907401(MYLK4) 112909931(MYLK2) 112913506(MYLK) 112914947(MYLK3)
AML: 100469244(MYLK2) 100473453(MYLK4) 100474254 100481263(MYLK)
UMR: 103665161(MYLK4) 103673818(MYLK3) 103674343(MYLK2) 103678824(MYLK)
UAH: 113252202(MYLK3) 113252350(MYLK) 113258196(MYLK2) 113264229(MYLK4)
ORO: 101368074(MYLK4) 101370711(MYLK3) 101378973(MYLK) 101381609(MYLK2)
FCA: 101088408(MYLK4) 101091744(MYLK3) 101095813(MYLK2) 494213(MYLK)
PTG: 102951994(MYLK2) 102962607(MYLK3) 102968305(MYLK4) 102972928(MYLK)
PPAD: 109249481(MYLK4) 109266499(MYLK) 109270987(MYLK3) 109272590(MYLK2)
AJU: 106965987(MYLK3) 106976155(MYLK4) 106984088(MYLK) 106986013(MYLK2)
BTA: 338037(MYLK) 518025(MYLK4) 526379(MYLK3) 533378(MYLK2)
BOM: 102264349(MYLK4) 102269080(MYLK) 102275601(MYLK3) 102276600(MYLK2)
BIU: 109555858(MYLK) 109567347(MYLK2) 109572727(MYLK3) 109577322(MYLK4)
BBUB: 102395214(MYLK3) 102402899(MYLK) 102412646(MYLK4) 102415047(MYLK2)
CHX: 102181454(MYLK4) 102181980(MYLK3) 102182147(MYLK2) 102190641(MYLK)
OAS: 101111897(MYLK2) 101113784(MYLK3) 105603910 443334(MYLK)
SSC: 100157526(MYLK4) 100524288(MYLK2) 110260971(MYLK3) 396848(MYLK)
CFR: 102505869(MYLK2) 102511426(MYLK3) 102515628(MYLK4) 102518144(MYLK)
CDK: 105086549(MYLK4) 105090282(MYLK) 105091178(MYLK3) 105100824(MYLK2)
BACU: 103005866(MYLK3) 103008421(MYLK) 103017148(MYLK2) 103020198 103020477(MYLK4)
LVE: 103077707(MYLK4) 103079981(MYLK2) 103083551(MYLK3) 103090456(MYLK)
OOR: 101275794(MYLK4) 101282343(MYLK) 101287286(MYLK3) 101289244(MYLK2)
DLE: 111165019(MYLK3) 111171109 111171669(MYLK) 111181276(MYLK4) 111184432(MYLK2)
PCAD: 102982196(MYLK3) 102982293(MYLK2) 102982405(MYLK) 102984346(MYLK4)
ECB: 100050092(MYLK4) 100053698(MYLK2) 100056559(MYLK3) 100070482(MYLK)
EPZ: 103540989 103547465(MYLK) 103548123(MYLK4) 103559162(MYLK2)
EAI: 106823711(MYLK) 106833720(MYLK2) 106842841(MYLK4) 106848229(MYLK3)
MYB: 102257771(MYLK3) 102258252(MYLK) 102259949(MYLK2) 102262704(MYLK4)
MYD: 102755283(MYLK2) 102759237(MYLK) 102765242(MYLK4) 102769513(MYLK3)
MNA: 107527244(MYLK) 107527759(MYLK2) 107535858(MYLK3) 107542256(MYLK4)
HAI: 109383050(MYLK3) 109384471(MYLK2) 109387190 109388085 109394028(MYLK4)
DRO: 112296778(MYLK3) 112297606(MYLK4) 112303707(MYLK2) 112320512(MYLK)
PALE: 102878549(MYLK3) 102890778(MYLK) 102891799(MYLK2) 102894361(MYLK4)
RAY: 107512268(MYLK3) 107512864(MYLK2) 107516607(MYLK4) 107518034(MYLK)
MJV: 108385316 108393093(MYLK2) 108396719(MYLK) 108402114(MYLK3)
LAV: 100656405(MYLK2) 100665634(MYLK4) 100677183(MYLK)
MDO: 100010869(MYLK2) 100015876(MYLK3) 100019648(MYLK) 100021377(MYLK4)
SHR: 100915288(MYLK2) 100918090(MYLK4) 100925131(MYLK3) 100930073(MYLK)
PCW: 110196726(MYLK4) 110207445(MYLK3) 110208127(MYLK) 110211415(MYLK2)
OAA: 100079091(MYLK4) 100091283(MYLK) 100092442(MYLK3) 114806177(MYLK2)
GGA: 396356(MYLK2) 396445(MYLK) 415748(MYLK3) 420893(MYLK4) 428278(MYLKSML)
MGP: 100538449 100542497(MYLK2) 100543918(MYLK4) 100547989(MYLK) 100551067(MYLK3)
CJO: 107309576(MYLK4) 107316813(MYLK) 107319273(MYLK3) 107323244(MYLK2) 107325036
NMEL: 110388525 110393482(MYLK4) 110400604(MYLK) 110404229(MYLK3) 110408280(MYLK2)
APLA: 101793167(MYLK3) 101794935(MYLK) 101799935(MYLK4) 101800032 101803931(MYLK2)
ACYG: 106029897(MYLK) 106039596(MYLK3) 106046900 106047119(MYLK2) 106048980(MYLK4)
TGU: 100218159(MYLK2) 100222880(MYLK4) 100226590(MYLK) 100232455(MYLK3)
LSR: 110468290(MYLK) 110469015(MYLK2) 110470711(MYLK4) 110475603 110475887(MYLK3)
SCAN: 103814310(MYLK) 103816608(MYLK3) 103818174(MYLK4) 103818839(MYLK2) 103821775
GFR: 102037734(MYLK4) 102037824(MYLK2) 102038683(MYLK3) 102044716(MYLK)
FAB: 101807258(MYLK) 101807804 101809550(MYLK3) 101813259(MYLK2) 101819869(MYLK4)
PHI: 102101059 102104582(MYLK2) 102106790(MYLK) 102111091(MYLK4) 102112254(MYLK3)
PMAJ: 107207555(MYLK) 107209810(MYLK3) 107213081(MYLK2) 107213960(MYLK4) 107215054
CCAE: 111923845(MYLK4) 111932252(MYLK) 111934649(MYLK3) 111938138(MYLK2) 111940063
CCW: 104687441(MYLK3) 104687839(MYLK2) 104694020(MYLK) 104698150(MYLK4) 104698538
ETL: 114058107(MYLK) 114060388(MYLK3) 114063040(MYLK2) 114070606 114071985
FPG: 101910574 101917440(MYLK3) 101922032(MYLK2) 101922066 101922502(MYLK)
FCH: 102050025(MYLK) 102051042(MYLK2) 102051053 102054950(MYLK4) 102058744(MYLK3)
CLV: 102085170 102088141 102093425(MYLK2) 102094050(MYLK4) 102095697(MYLK3)
EGZ: 104122823(MYLK4) 104125557(MYLK3) 104128132(MYLK) 104130019(MYLK2) 104132337
NNI: 104011279(MYLK3) 104018366(MYLK2) 104018798(MYLK) 104018914 104021845(MYLK4)
ACUN: 113476670(MYLK4) 113482370(MYLK) 113484301(MYLK3) 113489147
PADL: 103913791(MYLK3) 103919008(MYLK4) 103919603(MYLK) 103921929 103922199(MYLK2)
AAM: 106482002(MYLK4) 106483357(MYLK3) 106495651 106497378(MYLK2) 106499178(MYLK)
ASN: 102369318(MYLK2) 102371849(MYLK3) 102381743(MYLK) 102384108(MYLK4) 102387857
AMJ: 102557905 102560523(MYLK2) 102561520(MYLK) 102568638(MYLK3) 102574082(MYLK4)
PSS: 102448460(MYLK4) 102458914(MYLK3) 102461334(MYLK2) 102461616(MYLK)
CPIC: 101934934(MYLK4) 101935997(MYLK3) 101945225 101950238(MYLK2) 101951260(MYLK)
ACS: 100557929(mylk) 100559335(mylk3) 100562117(mylk2) 100567803(mylk4)
PVT: 110076324(MYLK3) 110083010(MYLK) 110086708(MYLK2) 110090626(MYLK4)
PMUR: 107284832(MYLK4) 107288928(MYLK) 107290115(MYLK3) 107300163
TSR: 106543664(MYLK) 106555816
PMUA: 114599828(MYLK2) 114600967(MYLK4) 114602252(MYLK3) 114603926(MYLK)
GJA: 107106205 107108885(MYLK3) 107113908(MYLK) 107116916(MYLK2)
XTR: 100489678(mylk) 100497991(mylk4) 100498081(xkr7) 100498243(mylk3) 101730432
NPR: 108785969 108786956(MYLK2) 108787381(MYLK4) 108801018(MYLK) 108802215 108802964(MYLK3)
DRE: 100003770(mylk5) 449707(mylk4b) 492576(mylkb) 558685(mylk2) 561635(mylk3) 566845(mylk4a) 569510(mylka)
SPU: 581963
APLC: 110985015
DME: Dmel_CG42347(sqa)
DER: 6542982
DSI: Dsimw501_GD10055(Dsim_GD10055) Dsimw501_GD25583(Dsim_GD25583)
DSR: 110179249
DPE: 6593039
DMN: 108159863
DWI: 6640809
DAZ: 108617147
DNV: 108653226
DHE: 111592113
MDE: 101900981
LCQ: 111684550
AAG: 5569428
AME: 413190
BIM: 100741566
BTER: 100649174
OBB: 114879979
AEC: 105151728
ACEP: 105618829
PBAR: 105424529
HST: 105190746
DQU: 106748004
CFO: 105256936
LHU: 105670307
PGC: 109858935
OBO: 105284545
PCF: 106790573
NVI: 100118913
MDL: 103570475
TCA: 659444
DPA: 109539715
BMOR: 101741803
BMAN: 114242701
PMAC: 106720800
HAW: 110374133
TNL: 113500367
API: 100163829
DNX: 107173153
AGS: 114121990
BTAB: 109031131
ZNE: 110826815
PVM: 113830372
TUT: 107363672
DPTE: 113799848
CEL: CELE_ZC373.4(mlck-1)
CBR: CBG01967
BMY: Bm1_37415
CRG: 105338083
MYI: 110463894
OBI: 106880214
SHX: MS3_00667
EGL: EGR_05091
EPA: 110232237
PYO: PY17X_1021700(PY07390)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8810874
  Authors
Kohama K, Ye LH, Hayakawa K, Okagaki T
  Title
Myosin light chain kinase: an actin-binding protein that regulates an ATP-dependent interaction with myosin.
  Journal
Trends Pharmacol Sci 17:284-7 (1996)
DOI:10.1016/0165-6147(96)10033-X
Reference
PMID:8575746
  Authors
Potier MC, Chelot E, Pekarsky Y, Gardiner K, Rossier J, Turnell WG
  Title
The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21.
  Journal
Genomics 29:562-70 (1995)
DOI:10.1006/geno.1995.9965
  Sequence
[hsa:4638]
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