KEGG   ORTHOLOGY: K03173
Entry
K03173                      KO                                     

Name
TRAF2
Definition
TNF receptor-associated factor 2 [EC:2.3.2.27]
Pathway
ko04010  MAPK signaling pathway
ko04064  NF-kappa B signaling pathway
ko04071  Sphingolipid signaling pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04217  Necroptosis
ko04380  Osteoclast differentiation
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04920  Adipocytokine signaling pathway
ko04932  Non-alcoholic fatty liver disease
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05135  Yersinia infection
ko05160  Hepatitis C
ko05163  Human cytomegalovirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03173  TRAF2; TNF receptor-associated factor 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04064 NF-kappa B signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04668 TNF signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04071 Sphingolipid signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03173  TRAF2; TNF receptor-associated factor 2
   04217 Necroptosis
    K03173  TRAF2; TNF receptor-associated factor 2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04622 RIG-I-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04657 IL-17 signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03173  TRAF2; TNF receptor-associated factor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03173  TRAF2; TNF receptor-associated factor 2
   05203 Viral carcinogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03173  TRAF2; TNF receptor-associated factor 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05014 Amyotrophic lateral sclerosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05016 Huntington disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05017 Spinocerebellar ataxia
    K03173  TRAF2; TNF receptor-associated factor 2
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K03173  TRAF2; TNF receptor-associated factor 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05132 Salmonella infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05131 Shigellosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05135 Yersinia infection
    K03173  TRAF2; TNF receptor-associated factor 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05160 Hepatitis C
    K03173  TRAF2; TNF receptor-associated factor 2
   05168 Herpes simplex virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05163 Human cytomegalovirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05169 Epstein-Barr virus infection
    K03173  TRAF2; TNF receptor-associated factor 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
   04121 Ubiquitin system
    K03173  TRAF2; TNF receptor-associated factor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03173  TRAF2; TNF receptor-associated factor 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     K03173  TRAF2; TNF receptor-associated factor 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03173  TRAF2; TNF receptor-associated factor 2
Genes
HSA: 7186(TRAF2)
PTR: 464876(TRAF2)
PPS: 100982095(TRAF2)
GGO: 101144745(TRAF2)
PON: 100458089(TRAF2)
NLE: 100590721(TRAF2)
MCC: 708391(TRAF2)
MCF: 101925175(TRAF2)
CSAB: 103239600(TRAF2)
RRO: 104669650(TRAF2)
RBB: 108542901(TRAF2)
CJC: 100404226(TRAF2)
SBQ: 101035434(TRAF2)
MMU: 22030(Traf2)
MCAL: 110289986(Traf2)
MPAH: 110318405(Traf2)
RNO: 311786(Traf2)
MUN: 110557003(Traf2)
CGE: 100762099(Traf2)
NGI: 103741188(Traf2)
HGL: 101705156(Traf2)
CCAN: 109699331(Traf2)
TUP: 102473925(C8G)
CFA: 480673(TRAF2)
VVP: 112906881(TRAF2)
AML: 100474087(TRAF2)
UMR: 103675245(TRAF2)
ORO: 101371938(TRAF2)
FCA: 101096363(TRAF2)
PTG: 102966802(TRAF2)
PPAD: 109258781(TRAF2)
AJU: 106989490(TRAF2)
BTA: 512355(TRAF2)
BOM: 102275265(TRAF2)
BIU: 109566626(TRAF2)
BBUB: 102395129 112577610(TRAF2)
CHX: 102184255(TRAF2)
OAS: 101105235(TRAF2)
SSC: 100513840(TRAF2)
CFR: 102511649(TRAF2)
CDK: 105106196(TRAF2)
BACU: 103013880(TRAF2)
LVE: 103088738(TRAF2)
OOR: 101281303(TRAF2)
DLE: 111177009(TRAF2)
PCAD: 102996185(TRAF2)
ECB: 100068006(TRAF2)
EPZ: 103567822(TRAF2)
EAI: 106845532(TRAF2)
MYB: 102263277(TRAF2)
MYD: 102772361(TRAF2)
MNA: 107536208(TRAF2)
HAI: 109381672(TRAF2)
DRO: 112306448(TRAF2)
PALE: 102889343(TRAF2)
RAY: 107503081(TRAF2)
MJV: 108406827(TRAF2)
LAV: 100670400(TRAF2)
TMU: 101354911
MDO: 100017243(TRAF2)
SHR: 100934749(TRAF2)
PCW: 110205309(TRAF2)
OAA: 100681066 100681935(TRAF2)
GGA: 417287(TRAF2)
MGP: 100545697(TRAF2)
CJO: 107321623(TRAF2)
NMEL: 110406784(TRAF2)
APLA: 101798982(TRAF2)
ACYG: 106037085(TRAF2)
TGU: 100223400(TRAF2)
LSR: 110472193(TRAF2)
SCAN: 103819084(TRAF2)
GFR: 102033115(TRAF2)
FAB: 101807272(TRAF2)
PHI: 102106384(TRAF2)
PMAJ: 107212160(TRAF2)
CCAE: 111936895(TRAF2)
CCW: 104688205(TRAF2)
ETL: 114064144(TRAF2)
FPG: 101911961(TRAF2)
FCH: 102059920(TRAF2)
CLV: 102095289(TRAF2)
EGZ: 104124021(TRAF2)
NNI: 104018369(TRAF2)
ACUN: 113486502(TRAF2)
PADL: 103921138(TRAF2)
AAM: 106494252(TRAF2)
ASN: 102384689(TRAF2)
AMJ: 102564363(TRAF2)
PSS: 102449635(TRAF2)
CMY: 102941067(TRAF2)
CPIC: 101933518(TRAF2) 101946577
ACS: 100561141(traf2) 100566904
PVT: 110087462(TRAF2)
PBI: 103050015 103066991(TRAF2)
PMUR: 107296550 107302543(TRAF2)
TSR: 106541963(TRAF2)
GJA: 107115164(TRAF2) 107118266
XLA: 108698135(traf2.L) 431974(traf2.S)
XTR: 100494415(traf2)
NPR: 108787259(TRAF2)
DRE: 100005446 557526(traf2b) 564295(traf2a)
IPU: 108255825 108259928(traf2)
PHYP: 113531130(traf2) 113537061
AMEX: 103028261(traf2) 103036375
CMK: 103183006(traf2) 103184612
APLC: 110981046
MYI: 110464971
OBI: 106879639
HMG: 100213781
 » show all
Reference
  Authors
He L, Grammer AC, Wu X, Lipsky PE
  Title
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
  Journal
J Biol Chem 279:55855-65 (2004)
DOI:10.1074/jbc.M407284200
Reference
  Authors
Mauro C, Crescenzi E, De Mattia R, Pacifico F, Mellone S, Salzano S, de Luca C, D'Adamio L, Palumbo G, Formisano S, Vito P, Leonardi A
  Title
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis.
  Journal
J Biol Chem 281:2631-8 (2006)
DOI:10.1074/jbc.M502181200
Reference
  Authors
Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC
  Title
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
  Journal
Cell Rep 3:724-33 (2013)
DOI:10.1016/j.celrep.2013.01.031
Reference
PMID:7639698
  Authors
Song HY, Donner DB
  Title
Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.
  Journal
Biochem J 309 ( Pt 3):825-9 (1995)
DOI:10.1042/bj3090825
  Sequence
[hsa:7186]
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